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Nonmelanocytic Lesions
Published in Ashfaq A Marghoob, Ralph Braun, Natalia Jaimes, Atlas of Dermoscopy, 2023
Constanza Riquelme-Mc Loughlin, Daniel Morgado-Carrasco, Susana Puig, Cristina Carrera
Poromas are benign tumors, but the structures and patterns they manifest are not reliable in differentiating them from malignant tumors such as porocarcinoma (Figure 6g.6). Thus, it is recommended that lesions suspicious for poroma undergo histopathology confirmation [7]. In addition, several cases of malignant transformation [10] and/or coexistence of poroma with porocarcinoma have been reported [1].
The skin
Published in C. Simon Herrington, Muir's Textbook of Pathology, 2020
Poroma is a cutaneous adnexal tumour which bears its name from a microscopic resemblance to and purported origin from the ducts (‘pores’) of sweat glands. It presents as an asymptomatic, solitary skin coloured to slightly erythematous nodule with a strong predilection for areas rich in eccrine sweat glands, e.g. palms and soles. The exact histogenesis of poromas (eccrine or apocrine) had been hotly debated in the past but most authorities now believe that majority of poromas have an eccrine lineage.
Benign Nonmelanocytic Skin Tumors
Published in Aimilios Lallas, Zoe Apalla, Elizabeth Lazaridou, Dimitrios Ioannides, Theodosia Gkentsidi, Christina Fotiadou, Theocharis-Nektarios Kirtsios, Eirini Kyrmanidou, Konstantinos Lallas, Chryssoula Papageorgiou, Dermatoscopy A–Z, 2019
Aimilios Lallas, Zoe Apalla, Elizabeth Lazaridou, Dimitrios Ioannides, Theodosia Gkentsidi, Christina Fotiadou, Theocharis-Nektarios Kirtsios, Eirini Kyrmanidou, Konstantinos Lallas, Chryssoula Papageorgiou
Eccrine poroma is a sweat gland tumor with many distinct histopathologic subtypes. Dermatoscopically, it has been characterized as “the great mimicker,” since it practically can assimilate all the frequent benign and malignant tumors. Eccrine poroma may be pigmented or nonpigmented. When pigmented, it may simulate melanoma or basal cell carcinoma as it may exhibit dermatoscopic features more commonly observed in the last tumors, namely brown or blue-gray pigmentation (Figures 4.37 and 4.38). Non-pigmented variants may mimic basal cell carcinoma or may display a polymorphous vascular pattern consisting of coiled, hairpin or linear vessels, thus mimicking amelanotic melanoma (Figure 4.39).
Poroid hidradenoma of the scalp in a US Veteran’s Administration (VA) patient
Published in Case Reports in Plastic Surgery and Hand Surgery, 2021
M. Mukit, M. Mitchell, I. Ortanca, N. Krassilnik, X. Jing
Poroid hidradenomas (PH) are a rare type of adnexal tumor. It is said that Abenoza and Ackerman were the first to describe them in 1990 [1]. Microscopic and immunohistochemical studies were subsequently done to further characterize this entity [2]. Poroid hidradenomas are a subtype of hidradenoma. Poroma and hidradenoma groups are interrelated, arising from a sweat duct, and sometimes show overlapping histological features. Hidradenomas divide into apocrine (‘clear cell’) and eccrine (‘poroid’) types. Other kinds of poroid neoplasms include eccrine poromas (EP), dermal duct tumors (DDT), and hidrocanthoma simplex (HS) [3]. These lesions have been described previously but mostly on a pathological basis. One histopathological series found only four poroid hidradenomas out of 18,653 biopsy specimens [3]. The largest case series reported fifty-six poroid hidradenomas but again, these specimens were mainly distinguished on a histologic basis [4]. These tumors arise from eccrine cells and are contained entirely in the dermis [5]. The risk of malignancy and metastasis is low but surgical excision is considered curative to prevent lesion growth and recurrence. Here we present the case of a scalp lesion in a VA patient with a non-descript clinical appearance, atypical surgical findings, and ultimate diagnosis of poroid hidradenoma on pathology.
Primary eccrine porocarcinoma of the thumb with multiple metastases: a case report and review of the literature
Published in Case Reports in Plastic Surgery and Hand Surgery, 2019
Connor McGuire, Zahir Fadel, Osama Samargandi, Jason Williams
Malignant eccrine porocarcinomas are rare, with fewer than 250 cases reported in the literature [7,8]. A review of 31 cases indicated that 65% of cases occurred on the lower extremities with the rest distributed to the head and trunk [7]. The mean age of patients was 68 years (range 42-90 years) and the distribution between genders was essentially equal. Interestingly, only four patients (12.9%) had metastases [7]. Histologic patterns were similar between specimens with most having infiltrating lymphatic vessels [5,7,9]. Histological examination of eccrine porocarcinomas typically shows tumor epithelium with large cells with irregular and hyperchromatic nuclei showing cytoplasm containing variable amounts of glycogen granules [3,10,11].The differential diagnosis for malignance eccrine porocarcinoma is broad and includes basal and squamous cell carcinomas, seborrheic keratosis, superficial spreading melanoma, fibromas, intraepidermal poroma, pyogenic granuloma, Paget’s disease, and Bowen’s disease [1,3,7].