China
Africa
Explore chapters and articles related to this topic
Movement disorders
Published in Ibrahim Natalwala, Ammar Natalwala, E Glucksman, MCQs in Neurology and Neurosurgery for Medical Students, 2022
Ibrahim Natalwala, Ammar Natalwala, E Glucksman
This patient has a history of mastectomy that is suggestive of previous breast cancer, and inability to tandem walk is a typical cerebellar sign (ataxia) (also dysdiadochokinesis, nystagmus, intention tremor, dysarthria and hypotonia). Therefore, paraneoplastic cerebellar degeneration is the most likely cause of the patient’s symptoms. Paraneoplastic cerebellar degeneration is an autoimmune disease where antibodies are directed against Purkinje cells in the cerebellum. It is often associated with lung, breast and ovarian cancers and Hodgkin’s lymphoma.7
Paraneoplastic Neurologic Symptoms in a Pediatric Patient with Hodgkin Lymphoma
Published in Cancer Investigation, 2021
Claire C. Baniel, Sarah S. Donaldson, Catherine Aftandilian, Susan M. Hiniker
Paraneoplastic cerebellar degeneration has been documented as a syndrome that precedes the diagnosis of Hodgkin lymphoma (9). In one case series, paraneoplastic cerebellar degeneration was observed 2 years prior to radiographic evidence of HL, despite frequent surveillance (10). A new diagnosis of cerebellar degeneration can be especially complicated in children, because of the acute causes of cerebellar dysfunction (such as infectious and autoimmune processes), but also genetic causes as well. Importantly, this patient’s symptoms stabilized within months of initial diagnosis of cerebellar degeneration (which is not uncommon for paraneoplastic cerebellar disease (8)), and resolved with treatment.
‘A Story Unheard’: anti-Ta associated paraneoplastic cerebellar degeneration in a female
Published in Journal of Community Hospital Internal Medicine Perspectives, 2019
Beenish Fayyaz, Ferry Gunawan, Eugene Obah
This case highlights the clinical scenario when a rare disorder presents with unusual manifestations. Paraneoplastic cerebellar degeneration is a clinical condition which can be difficult to diagnose due to its rare occurrence. In addition, our patient had clinical and serological features uncharacteristic of PCD such as an elderly female, positive anti-Ta antibodies and an excellent response to immunotherapy in the absence of an underlying malignancy.