Melanotic neuroectodermal tumor of infancy

Odontogenic Tumors

Published in Dongyou Liu, Tumors and Cancers, 2017

Odontogenic allied lesions (or bone-related lesions) encompass psammomatoid ossifying fibroma, trabecular ossifying fibroma, fibrous dysplasia, cemento-osseous dysplasia, central giant cell granuloma, cherubism, aneurysmal bone cyst, simple bone cyst, and melanotic neuroectodermal tumor of infancy [4].

Distinguishing Benign from Malignant Circumscribed Orbital Tumors in Children

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Journal Information

Published in Seminars in Ophthalmology, 2018

Yufei Tu, Frederick A. Jakobiec, Katherine Leung, Suzanne K. Freitag

Melanotic neuroectodermal tumor of infancy, also known as retinal anlage tumor or melanotic progonoma, is a rare, osteolytic-pigmented neoplasm of neural crest origin that develops during the first year of life.31 Commonly involving in maxilla, the orbit can rarely be affected. Microscopic examination reveals tubular or alveolar formations of large melanin-containing cells around nests of smaller neuroblastic cells possessing scant or fibrillar cytoplasm.31 Immunohistochemical study usually demonstrates that the tumor cells stain positively for cytokeratin, vimentin, epithelial membrane antigen, S-100, glial fibrillary acidic protein, neuron specific enolase, or HMB-45.32

Melanotic neuroectodermal tumor of infancy

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Odontogenic Tumors

Distinguishing Benign from Malignant Circumscribed Orbital Tumors in Children