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Sjögren's Disease
Published in Jason Liebowitz, Philip Seo, David Hellmann, Michael Zeide, Clinical Innovation in Rheumatology, 2023
Lymphomagenesis. Among systemic autoimmune diseases, SjD carries the highest risk for non-Hodgkin lymphoma development (157). Approximately 65% of cases are marginal-zone lymphomas of mucosa-associated lymphoid tissue (MALT), 15% are diffuse large B cell lymphomas (DLBCL), and 10% are nodal marginal-zone B cell lymphomas (158). The MALT lymphomas typically arise in the salivary glands, the target organ of the disease (159). Most are of low or intermediate grade and characterized by an indolent course, absent B symptoms, and excellent survival rates (160). DLBCL is associated with a higher rate of relapse and worse five-year survival rate of 75% (158). The risk factors associated with lymphomagenesis in SjD are summarized in Table 7.3.
The Non-Hodgkin’s Lymphomas and Plasma Cell Dyscrasias
Published in Harold R. Schumacher, William A. Rock, Sanford A. Stass, Handbook of Hematologic Pathology, 2019
Lynne V. Abruzzo, L. Jeffrey Medeiros
These neoplasms are believed to arise from splenic marginal-zone B cells, and are closely related to other marginal-zone B-cell lymphomas. Splenic marginal zone lymphoma (SMZL) is currently recognized as a provisional category in the Revised European-American Classification. Cases with prominent peripheral blood involvement also have been called splenic B-cell lymphoma with villous lymphocytes.
Chorioretinal biopsy
Published in A Peyman MD Gholam, A Meffert MD Stephen, D Conway MD FACS Mandi, Chiasson Trisha, Vitreoretinal Surgical Techniques, 2019
Approximately 85% of cases of PIOL arise from B cells.9,10 The rarer T-cell-type PIOL, was diagnosed on the basis of vitreous aspiration and chorioretinal biopsy by Coupland. His group reported that the utilization of gene rearrangement studies on vitreous or chorioretinal biopsies increases the chances of diagnosing or excluding a PIOL.20 Coupland et al21 also reported a case of extranodal marginal zone B-cell lymphoma diagnosed with a chorioretinal biopsy (chorioretinal biopsy is discussed below).
Orbital marginal cell lymphoma and mantle cell lymphoma subclone in patient with monoclonal gammopathy of unknown significance
Published in Orbit, 2021
Sitara H. Hirji, Michelle M. Maeng, Andrea A. Tooley, Craig Soderquist, Joseph Annunziata, Michael Kazim
Orbital lymphomas are rare, comprising 1% of all non-Hodgkin lymphomas.2 The majority of such lymphomas are extranodal marginal zone B cell lymphomas, as was the stem line of the case presented above. Ocular adnexal mantle cell lymphoma is most commonly found in older men, and it has a tendency to present bilaterally in the context of disseminated stage IV disease.21 The standard treatment for isolated marginal zone orbital lymphomas is radiation therapy alone,22 and that for isolated mantle cell orbital lymphoma is chemotherapy with or without radiation therapy.21 In this case, however, systemic treatment with rituximab was recommended due to the presence of the mantle cell subclone. The presence of lymphoid clonal expansion in peripheral blood and possible colonic involvement in the patient’s past medical history further supported the need for systemic treatment. To date, the patient has experienced incomplete response to rituximab alone.
Splenic marginal zone B-cell lymphoma associated with ruptured breast implants: case report and review of the literature
Published in Case Reports in Plastic Surgery and Hand Surgery, 2021
Mark G. Evans, Melissa A. Mueller, Frederik Chen, Larry S. Nichter
Splenic marginal zone B-cell lymphoma is a rare malignancy, accounting for less than 2% of all lymphoma cases [12]. It was first described in 1992 and is now considered a separate entity in the World Health Organization (WHO) classification [13]. The three types of marginal zone B-cell lymphomas are splenic marginal zone lymphoma (SMZL), nodal marginal zone lymphoma (NMZL), and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). The diagnosis of SMZL is made based on lymphocyte morphology, immunophenotype, cytogenetic abnormalities, bone marrow histology, and spleen histology if available. When microscopic examination of the spleen is not possible, clinical splenomegaly and typical morphologic and immunophenotypic blood and bone marrow findings are sufficient to make a diagnosis.
Epidemiology, outcomes, and prognostic factors of orbital lymphoma in the United States
Published in Orbit, 2020
Osama M. Ahmed, Anthony K. Ma, Taha M. Ahmed, Renelle Pointdujour-Lim
It has been observed that the various histologic subtypes of OL confer different overall survival rates.4,10–12 In the largest study reporting the effect of histologic subtype of OL on survival, Olsen et al found extranodal marginal zone B cell lymphoma to confer the best prognosis and mantle cell lymphoma to confer the worst prognosis in a cohort of 797 patients from seven international cancer centers.11 However, patients in the United States accounted for only 30% of their cohort and were included from only three regional cancer centers. Moreover, no subgroup analysis was performed in their study for survival amongst the American cohort.