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Benign Neoplasms
Published in Ayşe Serap Karadağ, Lawrence Charles Parish, Jordan V. Wang, Roxburgh's Common Skin Diseases, 2022
Abdullah Demirbaş, Ömer Faruk Elmas, Necmettin Akdeniz
Clinical presentation: Junctional nevus is a brown-black well-circumscribed macule with a diameter smaller than 0.5 cm. (Figure 19.2)Compound nevus are brown nodules or papules arising from the surface. (Figure 19.3)Intradermal nevus (dermal) is a skin-colored or light-brown polypoid lesions, often without pigment. (Figure 19.4)Variants include balloon cell nevus, inverted type A nevus, eccrine-centric nevus, and Cockade nevus.
Malignant Melanoma
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2020
Cutaneous melanomas can be categorized on the basis of their macroscopic appearance: Superficial spreading (70% cases), nodular (20%), acral lentiginous (5%), and lentigo maligna melanoma (5%). Superficial spreading melanoma often arises as a dark area within a pre-existing junctional nevus. Nodular melanoma typically arises from apparently normal skin and is aggressive. They are usually darker than superficial spreading melanoma, uniform in color, and often dome-shaped. Rarely, nodular melanomas are amelanotic. Acral lentiginous melanoma affects the palms, soles, and nail beds. They are more common in darker skinned individuals. Lentigo maligna melanoma tends to occur on the face or neck of older patients and has a better overall survival.
Melanomas
Published in E. George Elias, CRC Handbook of Surgical Oncology, 2020
The differential diagnosis of cutaneous melanoma involves other pigmented lesions that may contain melanocytes or hemosiderin. Benign nevi are uniformly colored (tan to brown), have sharp, clear-cut margins, without nodularity, and are usually 0.5 cm or less in diameter. Benign nevi appear during childhood and adolescence and are multiple. By age 20, they may reach 25 to 30 in number, then gradually decrease in number. Pathologically, there are three types of benign nevi: Intradermal nevus can occur anywhere in the body except the palms, soles, and genitalia. Microscopically, benign nests or cords of cells are located in the dermis below the basal cell layer of the epidermis.Junctional nevus can occur anyplace in the body but more often in the palms, soles, and genitalia. Clinically, it cannot be differentiated from the intradermal nevus except by the clinical location. Histologically, nests of cells with occasional clear cells are in the epidermis, and it may involve the basal cells.Compound nevus can be found at any site but mainly on the trunk. Microscopically, it is a combination of intradermal nevus with junctional activity.
Mohs micrographic surgery versus wide local excision for head and neck melanoma-in-situ
Published in Journal of Dermatological Treatment, 2020
Kevin Phan, James Onggo, Asad Loya
We retrieved data from the year 1998 to 2015 for analysis. Parameters included were patient demographics, tumor primary site and laterality, tumor histology and morphology, treatment regimen and survival rates. Using the International Classification of Disease for Oncology (ICD O-3), patients diagnosed with varying subtypes of MIS were identified. The following histologies were included: MIS (8720/2), nodular melanoma, in situ (8721/2), balloon cell melanoma, in situ (8722/2), MIS, regressing (8723/2), amelanotic melanoma, in situ (8730/2), MIS in junctional nevus (8740/2), superficial spreading MIS (8743/2), acral lentiginous melanoma, in situ (8744/2), desmoplastic melanoma, in situ (8745/2), mucosal lentiginous MIS (8746/2), MIS in compound nevus (8760/2), MIS in giant pigmented cell (8761/2), epithelioid and spindle cell MIS (8770/2), epithelioid cell MIS (8771/2), and spindle cell MIS (8772/2).