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DRCOG MCQs for Circuit C Questions
Published in Una F. Coales, DRCOG: Practice MCQs and OSCEs: How to Pass First Time three Complete MCQ Practice Exams (180 MCQs) Three Complete OSCE Practice Papers (60 Questions) Detailed Answers and Tips, 2020
Ovarian tumours that secrete oestrogen include:Arrhenoblastoma.Dysgerminoma.Teratoma.Granulosa cell tumour.Thecoma.
Ovarian cancer
Published in Anju Sahdev, Sarah J. Vinnicombe, Husband & Reznek's Imaging in Oncology, 2020
Stephanie Nougaret, Helen Addley, Evis Sala, Anju Sahdev
Malignant granulosa cell tumours account for about 70% of all malignant SCSTs and 3%–5% of all ovarian neoplasms. They are divided into adult (95%) and juvenile (5%) types. The adult type manifests mostly in perimenopausal women (median age: 50–54 years), whereas the juvenile type predominates in prepubertal girls (median age: 13 years) (52,53). MRI features of granulosa cell tumours vary, but certain findings may point to the correct diagnosis. In addition to clinical information including perimenopausal status, menometrorrhagia, and elevated inhibin level, suggestive MR features are high SI on T1WI (intralesional haemorrhage), ‘sponge-like’ or ‘Swiss cheese’ appearance on T2WI (multiple cysts interspersed within a solid mass), and enhancing solid components (Figure 19.9). Findings indicative of juvenile granulosa cell tumour are age <30 years, isosexual precocious puberty, an elevated inhibin level, and MRI appearances similar to adult type. Rarely, juvenile granulosa cell tumours may manifest as intermediate-to-high SI solid masses or a predominantly cystic lesion with a solid component. Peritoneal metastases and associated endometrial hyperplasia or carcinoma should be excluded on imaging (Figures 19.10 and 19.11) (54,55).
Fertility preservation strategies
Published in David K. Gardner, Ariel Weissman, Colin M. Howles, Zeev Shoham, Textbook of Assisted Reproductive Techniques, 2017
Stine Gry Kristensen, Claus Yding Andersen
Most importantly, no relapses have been reported at any graft sites. However, one case report documented a relapse concerning the recurrence of a granulosa cell tumor, but no evidence of tumor was found at the graft site (81). This could suggest that ovarian diseases may require stricter precautions.
Mucinous cystadenoma with fibroma: a rare combination of collision tumour
Published in Journal of Obstetrics and Gynaecology, 2022
Tanisha Singla, Chintamani Pathak, Anam Singh, Gaurav Singla, Swati Singla, Naveen Kumar R.
Surface epithelial tumours are the commonest (65%), whereas sex cord stromal tumours account for 10% of the ovarian neoplasms. However, their combination in the form of a collision tumour are extremely rare. Various combinations of ovarian tumours that have been reported in the literature include cystadenocarcinoma and dermoid cyst (Bige et al. 2009), teratoma and mucinous cystadenoma (Tang et al. 2003), serous cystadenocarcinoma and teratoma, carcinosarcoma and dermoid cyst, choriocarcinoma and cystadenoma, sarcoma and mucinous tumour, mucinous cystadenoma coexisting with stromal tumour with sex cord elements (Yang et al. 2001), serous cystadenoma and Sertoli-Leydig cell tumour, granulosa cell tumour and ovarian hepatoid carcinoma (Triratanachat et al. 2004). Adult granulosa cell tumour has also been reported in combination with mucinous cystadenoma. Theory of histogenesis includes collision tumour and heterologous mucinous differentiation within an AGCT. The latter theory has been preferred because in few case reports there was admixture of the mucinous component with the granulosa component. Also, similar heterologous mucinous differentiation has been well described in Sertoli-Leydig cell tumours. But in our case there was distinct interface between the two components and the combination of mucinous cystadenoma and fibroma has not been reported to-date.
Sex-Cord Tumor with Annular Tubules with Unusual Morphology in an Infant with Peutz-Jeghers Syndrome
Published in Fetal and Pediatric Pathology, 2022
Priyanka Maity, Nandini Das, Uttara Chatterjee, Dhananjay Basak
SCTAT and Sertoli cell tumors show some degree of overlap in the morphology. Some cases with hybrid features of sex-cord stromal tumors may be difficult to classify because of their unique morphology. Sometimes, within aggregates of the tubular formations in SCTAT, there is a proliferation of cells with a solid pattern that may be composed of lipid-rich cells, as we observed in this case. The SCTAT may evolve into a confluent overgrowth of cells with Sertoli cell characteristics with diffuse growth of oxyphilic cells or lipid-rich cells. Tubular pattern is common to both Sertoli cell tumor and SCTAT; however, the tubules in Sertoli tumors tend to be hollow. The characteristic pink concretions, within the limited areas of tubular differentiation in our case, favored a diagnosis of SCTAT. An unusual case of co-existing Sertoli cell tumor and SCTAT in a case of PJS in an 11-year-old girl has been described. She had no hormonal symptoms [3]. Steroid cell tumor was excluded by the presence of tubular differentiation and the tumor cells did not have the abundant eosinophilic cytoplasm of steroid cell tumors. Our tumor lacked the architectural and nuclear features of a luteinized granulosa cell tumor. Another close morphological mimic is the gonadoblastoma, which contains germ cells and occurs in an altogether different clinical setting associated with dysgenetic gonads in patients of disorders of sexual differentiation.
The incidence of unexpected gynaecological malignancies in hysterectomies carried out for benign indications
Published in Journal of Obstetrics and Gynaecology, 2021
Gazi Yildiz, Emre Mat, Pinar Yildiz, Elif Cansu Gundogdu, Gulfem Basol, Didar Kurt, Ahmet Kale
Of cases with ovarian cancer, 4/7 (57.14%) had granulosa cell tumour, 2/7 (28.57%) had serous carcinoma and 1/7 (14.28%) had mucinous carcinoma. The mean diameter of ovarian tumours was 5.28 ± 4.37 cm. All 7 patients with unexpected ovarian cancer were menopausal. Among these patients, three were operated for ovarian cyst and the remaining patients were operated for benign pathologies. These three patients had normal preoperative serum Ca-125, Ca 19-9, AFP, LDH and hCG values and pelvic Doppler ultrasonography and magnetic resonance imaging results of the patients showed benign characteristics. Of cases with granulosa cell tumour, 2/4 cases (50%) had undergone hysterectomy for myoma uteri, 1/4 cases (25%) had undergone hysterectomy for endometrial polyp, and the remaining case who had undergone hysterectomy for ovarian cyst of 12 cm in diameter whose intraoperative frozen section examination result was benign stromal tumour. In serous and mucinous tumour cases, normal preoperative serum Ca-125 values and benign characteristics in intraoperative frozen section examination were found. Among ovarian cancer cases, patient with mucinous carcinoma at stage 1C1 had received chemotherapy, while the only case with serous carcinoma at stage 1C2 had undergone complementary surgery (pelvic and paraaortic lymh node dissection, omentectomy) and received adjuvant chemotherapy (Table 2).