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Appendiceal Cancer
Published in Dongyou Liu, Tumors and Cancers, 2017
Patients suspected of appendicitis are often examined by CT; and those suspected of carcinoid syndrome are tested for urinary excretion of 5-HIAA and serum chromogranin A levels. Complete colonoscopy may be used to evaluate synchronous colorectal lesions. Final diagnosis of appendiceal cancer is made upon histological assessment of appendix after appendectomy.
Systemic therapy for appendiceal cancer
Published in Wim P. Ceelen, Edward A. Levine, Intraperitoneal Cancer Therapy, 2015
After presentation of the published literature, it is clear that the role of systemic therapy in the treatment of appendiceal cancer should be tested in a prospective, randomized setting. Appendiceal cancer has long been classified and studied with other, more common types of cancer such as colorectal, ovarian, and primary peritoneal cancers [1]. Because appendiceal cancer is a rare disease with a substantial amount of heterogeneity, conclusive decisions are difficult to obtain. This scenario clouds the picture when deciding when to use systemic therapy and what chemotherapy and/or biologic therapy regimens and duration of therapy to choose.
A Nomogram for Predicting Lymph Nodal Metastases in Patients with Appendiceal Cancers: An Analysis of SEER Database
Published in Journal of Investigative Surgery, 2021
Dan Wang, Chongshun Liu, Tingyu Yan, Chenglong Li, Cenap Güngör, Qionghui Yang, Yang Xu, Lilan Zhao, Qian Pei, Fengbo Tan, Yuqiang Li
The current epidemiological survey showed that the annual incidence of appendiceal cancer was about 0.12 per 100,000 people [1,2], which presented that appendiceal cancer is an infrequent cancer with mounting incidence. Furthermore, the prognosis of appendiceal cancer is poor since the aggressive malignancy and a late stage at diagnosis [1]. Moreover, most of patients with appendiceal cancer cannot be diagnosed preoperatively and usually found incidentally following routine appendectomy for signs and symptoms of acute appendicitis [3–5]. With the development of medical technology, more options, including simple appendectomy, right hemicolectomy and even large debulking procedures with the hyperthermic intraperitoneal chemotherapy, are available for the therapies of appendiceal cancer. However, it is controversial regarding the best treatment for appendiceal cancer [6–10].
Predicting Lymph Nodal Metastases in Patients with Appendiceal Cancers
Published in Journal of Investigative Surgery, 2021
N. Tsoukalas, M. Galanopoulos, K. Tsapakidis, E. Karamitrousis, K. Kamposioras
So far, there is lack of specific guidance, or consensus between scientific societies about the exact criteria by which an individual with appendiceal cancer should be treated with a more extensive surgical approach rather than a simple appendectomy. Previous reports have identified certain risk factors that were correlated with lymphatic spread which would guide for a more aggressive surgical intervention. However, they were limited by the small number of patients and the lack of combination of suggested risk factors to better characterize the high risk group. According to the current recommendations, all non-carcinoid tumors should undergo right hemicolectomy, whereas the type of surgical intervention for carcinoid tumors of the appendix depends on size, high grade or high mitotic index, mesoappendiceal invasion, location, and presence of goblet-cell histology [2, 7].
Identification of risk factors associated with postoperative acute kidney injury after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a retrospective study
Published in International Journal of Hyperthermia, 2018
Juan P. Cata, Acsa M. Zavala, Antoinette Van Meter, Uduak U. Williams, Jose Soliz, Mike Hernandez, Pascal Owusu-Agyemang
The average (standard deviation) patient age was 51 (12.65) years (Table 1). There were more female (55.1%) than male (44.8%) patients. The majority of participants were overweight (35.8%) or obese (35.0%), and over 80% of patients had an American Society of Anesthesiologists (ASA) score of 3. Diabetes mellitus (37%) and chronic pulmonary disease (15%) were the most common comorbidities. A small percentage (3.1%) of the patients were taking cardiovascular medications at the time of surgery. Most patients (71.4%) had appendiceal cancer. Other tumour diagnoses included: colorectal (10.3%), mesothelioma (8.8%), desmoplastic round cell tumour (7.0%) and other cancers (2.5%). Forty-three percent of patients had moderate to high tumour grades, and 44.8% of patients received neoadjuvant chemotherapy. At the time of surgery, only 3.5% of the patients had extra abdominal disease.