Carbonyl sulfide

Carbonyl sulfide

Biochemical Aspects of Fatty Liver

Published in Robert G. Meeks, Steadman D. Harrison, Richard J. Bull, Hepatotoxicology, 2020

The action of CS2 would be a consequence of the strong decrease of cytochrome P450 action this substance produces (Bond and De Matteis, 1969). In fact, CS2 toxicity increases after induction of the enzymatic system by phenobarbital (De Lamatre et al., 1983). These facts favor the hypothesis that toxicity is related to the metabolism of the poison in the SER. Here, CS2 might undergo oxidation to the intermediate compound S-CO-S, which would then be cleaved homolitically to give carbonyl sulfide (S-CO) and a single sulfur atom. This is highly reactive. After fixation to the structures of the SER, it could start the damage leading to severe fatty infiltration and necrosis (Dalvi et al., 1974).

Synthesis and characterization of meloxicam eutectics with mandelic acid and saccharin for enhanced solubility

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Journal Information

Published in Drug Development and Industrial Pharmacy, 2020

Richard Perosa Fernandes, Ana Carina Sobral de Carvalho, Bruno Ekawa, Andre Luiz Soares Carneiro do Nascimento, Andressa Maria Pironi, Marlus Chorilli, Flávio Junior Caires

In addition, to discard the formation of solvate or residue of ethanol in the eutectics, an EGA of MLX-MND and MLX-SAC were performed (Supplementary Figure 5S). Gram–Schmidt curve shows the total absorbance detected by FTIR during TG-DSC analysis. The major gaseous products identified were carbon dioxide and carbonyl sulfide, with maximum regions at 22–28 min (MLX-MND and MLX-SAC eutectics), 48–64 min (MLX-MND eutectic), 77–80 min (MLX-SAC eutectic). Signals relative to ethanol were not observed, excluding the presence of solvent in the eutectic synthesized.

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Biochemical Aspects of Fatty Liver

Synthesis and characterization of meloxicam eutectics with mandelic acid and saccharin for enhanced solubility