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Cervical Cancer Screening And Management In Pregnancy
Published in Vincenzo Berghella, Obstetric Evidence Based Guidelines, 2022
Vaidehi Mujumdar, Scott D. Richard
Unlike standard recommendations for cervical conization in non-obstetric patients with inadequate colposcopy biopsies or discordance between Pap smears and colposcopic biopsies [15], pregnant individuals with these findings can defer further examination until after pregnancy if invasive cancer has been ruled out. If a cervical conization must be performed during pregnancy, this procedure should ideally be performed in the early second trimester.
Prelabor rupture of the membranes
Published in Hung N. Winn, Frank A. Chervenak, Roberto Romero, Clinical Maternal-Fetal Medicine Online, 2021
Roberto Romero, Lami Yeo, Francesca Gotsch, Eleazar Soto, Sonia S. Hassan, Juan Pedro Kusanovic, Ray Bahado-Singh
Uterine cervical pathology: Women who had surgery in the lower genital tract, such as cervical conization (56,57) or previous spontaneous abortions (58), are at greater risk for preterm PROM. Buchmayer et al. reported that a history of two or more spontaneous abortions was associated with an odds ratio of 4.1 (95% CI: 2.2–7.8) for preterm PROM (58). We propose that some degree of cervical insufficiency (e.g., a short cervix resulting in an inadequate mucous plug) predisposes to ascending intrauterine infection (59,60). This hypothesis would explain the link between a short cervix and subsequent preterm PROM (25). It is noteworthy that a cervical length <25 mm confers an increased risk for preterm PROM before 35 weeks of gestation in nulliparas (OR: 9.9) as well as in multiparas (OR: 4.2) (25).
Management of pregnancy with recurrent preterm deliveries
Published in Minakshi Rohilla, Recurrent Pregnancy Loss and Adverse Natal Outcomes, 2020
Cervical insufficiency due to mechanical factors is also an important cause of preterm births. The history of cervical conization, loop electrosurgical excision procedure (LEEP), obstetric injury to the cervix, or intrinsic causes like congenital uterine anomalies and collagen vascular disorder, are important causes of cervical insufficiency.
Oncoprotective Effects of Short-Chain Fatty Acids on Uterine Cervical Neoplasia
Published in Nutrition and Cancer, 2019
Madoka Matsuya-Ogawa, Toshiaki Shibata, Hiroaki Itoh, Hirotake Murakami, Chizuko Yaguchi, Kazuhiro Sugihara, Naohiro Kanayama
The human samples of uterine cervical tissues were collected from patients undergoing biopsy or surgery at our hospital. During the period for 5 yr, 85 patients were treated for cervical cancer and 180 patients underwent cervical conization for cervical intraepithelial neoplasia in our hospital. All tissues are embedded in paraffin blocks and preserved as glass slides of hematoxylin and eosin staining for histopathological diagnosis. In this study, we first evaluated the hematoxylin and eosin-stained slides and selected the samples that are in good condition for validation. In the samples taken after surgery, we enrolled only those continuation from epithelium to stroma was clearly preserved. In small tissue specimens of invasive cancer before primary chemoradiation therapy, we excluded the specimens if they were too small, or characterized by massive necrosis or bleeding. As a result, we enrolled 11 patients (29–62 yr old) with cervical intraepithelial neoplasia as well as 32 patients (32–92 yr old) with cervical cancer who underwent punch biopsy, conization, or hysterectomy as an initial treatment at our hospital, were diagnosed with cervical cancer, FIGO stage IA to IVB (Supplementary Table 1). The clinical background information of patients was extracted from electronic medical records.
The Impact of Minimally Invasive Surgery on Treating Patients with Early Cervical Adenocarcinoma
Published in Journal of Investigative Surgery, 2022
Hui Zhu, Yifen Yan, Ying Liu, Linghu Meng
The age group with the highest incidence of CC in China is 40-55 years old. The current treatment for cervical cancer is radiotherapy, chemotherapy and surgery [8, 9]. An increasing number of patients are being diagnosed with early-stage cervical cancer (IA-IIA) due to the popularity of pre-cervical cancer screening. Cervical lesions often require conical resection of the cervical scaly column junction for clinicopathological examination to confirm the diagnosis. Cervical conization is the most important measure for the treatment of early invasive cancer, and radical hysterectomy is often continued after the pathological confirmation of cervical cancer by pre-operative conization specimen. Surgery is the basic surgical method for the treatment of CC, among which the most widely used is extensive hysterectomy, which can remove paruterine, lymph nodes, parcervix, parvaginal and proximal vaginal tissues to achieve the effect of radical cure [8]. However, hysterectomy with CL is traumatic, and is easily to cause pelvic autonomic nerve injury, affecting the function of related organs [8]. With the continuous progress of laparoscopic technology, extensive hysterectomy by MIS with the help of laparoscopy has gradually received clinical attention because of its minimally invasive characteristics, amplification function, and the ability to achieve fine anatomy and reduce trauma [10, 11]. However, compared with open surgery, previous studies concluded laparoscopic surgery has higher recurrence and mortality in patients with early CC3 [6]. Therefore, the NCCN guideline clearly indicated that the standard surgical method for CA is CL, which has triggered a heated debate on the surgical method of radical CC surgery. Therefore, this study investigated the impact of MIS in patients with early CA.
An unusual complication of LEEP cervical conisation with a retained intrauterine device (IUD): a case report
Published in Journal of Obstetrics and Gynaecology, 2019
Ayhan Gül, Ayşe Gül Kebapçılar, Gözde Şahin, Serra Akar, Çetin Çelik
Cervical conisation is a procedure performed for diagnostic and therapeutic purposes in cervical dysplasia and malignancies. One of the methods used for conisation is the LEEP procedure in which a thin wire loop cautery is used to remove the tissue surrounding the cervical canal and the transformation zone as a cone (Berek and Hacker 2015). The most common complications of LEEP are postoperative bleeding and infection. Cervical stenosis and cervical insufficiency are seen less frequently (Kietpeerakool et al. 2006; Monteiro et al. 2008; Noehr et al. 2009).