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Comparison of Healing Effect of DMSP in Green Sea Algae and Mesenchymal Stem Cells on Various Inflammatory Disorders
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Senility proceeds obligatorily in all living things with aging via adult stages. The senility causes various dysfunctions of body, which elicits several critical disorders in brain of humans (WHO, 2016. Dementia). Among the dysfunctions, there is a major calamity, dementia, among aged people. Dementia is a crucial chronic or progressive disorder, in particular, confers loss of learning and memory, orientation, and every behavior to the patients. The patients suffering from dementia (neurological diseases) induced by denaturation and retardation of central nerves have to undergo heavy clinical, social and psychological impairments. Moreover, not only the patients but also their families and society have a great impact (WHO, 2016. Dementia). As people live longer in the world, people suffereing from dementia drastically increase (WHO, 2014. Ageing and life-course).
Objections to the Basic Moral Status of Human Embryos
Published in Christopher Kaczor, The Ethics of Abortion, 2023
As noted, size itself is completely irrelevant to personhood. If healthy adult human beings were somehow shrunk to tiny size, no one would deny their right to live. So let us posit a slightly different case of shrinkers to focus our intuitions on morally relevant characteristics. Imagine beings that do not shrink but remain basically the same size in maturity. However, like shrinkers, these beings who were once rational will never rationally function again. They have permanently lost their rational faculties. Indeed, we do not need to imagine such beings because they already exist. Severely mentally handicapped human beings fit within this category, at least those who became handicapped as adults. Advanced Alzheimer's patients are in the same condition as are human beings with severe senility. Since it is morally wrong to kill these human beings intentionally, so, too, would it be wrong to kill shrinkers, whether they shrank or not. Thus, shrinkers provide no basis for denying basic respect to the human embryo.
Healthy and Successful Aging
Published in Joseph P. Hou, The Healing Power of Ginseng, 2019
Doctors call the normal process of aging “senescense,” meaning to grow old or the state of being old. Some people who grow old may have physical or mental difficulties, and doctors call this aging process “senility,” to describe problematic aging. The difficulties of senility are most commonly associated with serious impairment of mental functions, such as dementia or Alzheimer disease.
Too late for love? Sexuality and intimacy in heterosexual couples living with an Alzheimer’s disease diagnosis
Published in Sexual and Relationship Therapy, 2023
The findings of this study seem to support the above propositions: age and life course position appear to be of particular importance to couples’ meaning-making regarding sexuality and intimacy after an Alzheimer’s disease diagnosis. It is worth noting changes both in how sexuality and cognitive function in later life are viewed, where both the terms “senility” and “old age impotence” have in recent decades been substituted by medical discourses on “dementia” (or the more recent DSM-V classification: neurocognitive disorder) and “erectile dysfunction” (Ballenger, 2006; Katz, 2012; Lock, 2013; Marshall & Katz, 2002). These new terminologies on memory/cognitive and sexual functioning create a clearer divide between normal/healthy and abnormal/pathological sexual function and ageing. This may impact the everyday lives of couples who receive a dementia diagnosis, where successful ageing is increasingly centred around cognitive functioning as well as continued sexual activity through penile–vaginal intercourse. Still the consequences of age should not be overstated, with Anna and Anders, for example having been together considerably shorter than the other couples, which could also have impacted on how they coped with the illness.
Circ_0110251 overexpression alleviates IL-1β-induced chondrocyte apoptosis and extracellular matrix degradation by regulating miR-3189-3p/SPRY1 axis in osteoarthritis
Published in Autoimmunity, 2022
Yawei Zhang, Hengheng Zheng, Baitong Li
Osteoarthritis (OA) is an age-related or post-traumatic degenerative joint illness featured by progressive loss of transparent articular cartilage [1,2]. OA affects 18% of women and 10% of men older than 60 years old [1]. The identified risk factors include obesity, senility, strain, heredity, gender, joint deformity and so on, which are related to the progression of OA [3]. However, the exact pathogenesis of OA remains unclear. Currently, treatment methods are limited, and there are no effective treatment methods for OA. OA is featured by chondrocyte apoptosis and extracellular matrix (ECM) degradation, leading to the loss of articular cartilage structure and function, accompanied by cartilage repair and osteophyte formation [4,5]. Moreover, the activities of proinflammatory cytokines IL-1β, IL-6 and TNF-α contribute to OA pathogenesis by promoting proteolytic enzyme activity that damages ECM degradation in cartilage [6–8]. Therefore, elucidation of the mechanisms related to apoptosis, inflammation and ECM degradation will help to find methods for OA therapy.
(Un)Ethical Early Interventions in the Alzheimer’s “Marketplace of Memory”
Published in AJOB Neuroscience, 2021
Daniel R. George, Peter J. Whitehouse
Over the last century, Alzheimer’s disease has proven a highly malleable concept. Initially an obscure diagnosis pertaining to rare cases of young onset dementia, by the latter half of the 20th century the label had replaced “senility” as the global shorthand for age-related memory loss—a discreet end-of-life disease amenable to cure (Whitehouse and George 2008). However, failures to develop effective therapies in the 21st century have, as McKeown, Malhi, and Singh (2021) write, engendered another paradigmatic shift away from late-stage treatments and toward a pre-symptomatic model aimed at identifying the condition upstream using biomarkers/genes and interceding with “personalized” treatments. New socially-constructed “pre-disease” categories such as Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), and preclinical Alzheimer’s have emerged to promote treatment of milder-and-milder forms of memory loss—the latter construct representing a situation wherein Alzheimer’s-associated biomarkers are present in the absence of clinical signs and symptoms.