Positive association between cerebral grey matter metabolism and dopamine D2/D3 receptor availability in healthy and schizophrenia subjects: An 18F-fluorodeoxyglucose and 18F-fallypride positron emission tomography study
Published in The World Journal of Biological Psychiatry, 2020
Serge A. Mitelman, Monte S. Buchsbaum, Bradley T. Christian, Brian M. Merrill, Bradley R. Buchsbaum, Jogeshwar Mukherjee, Douglas S. Lehrer
FDG images were normalised by dividing each voxel by mean values of the whole brain, masked with MNI brain and using slices above MNI z = −53 (see image alignment in a typical subject with schizophrenia in Figure 1). A restricted vertical range was chosen to minimise errors in the brain extraction routine at low slice levels. These relative 18F-fluorodeoxyglucose metabolic rates were used in all analyses. For analyses of 42 Brodmann areas, gyri, hippocampus, insula, and subcortical structures, FDG uptake and 18F-fallypride BPND values were obtained using AFNI regions of interest (Cox 1996). Subcortical structures included the amygdala, cerebellar subregions (tonsil, culmen, declive, tuber and pyramid of the vermis, dentate and fastigial nuclei), basal ganglia associated structures (head, body and tail of the caudate nucleus, putamen, lateral globus pallidus, medial globus pallidus, red nucleus, substantia nigra, claustrum), hypothalamus and mamillary bodies, thalamic nuclei (pulvinar, ventral anterior, lateral dorsal, ventral lateral, ventral posteromedial, lateral posterior, ventral posterolateral, mediodorsal as well as anterior and midline nuclear groups).