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Combination Approaches: Using Fillers With Toxins and Energy-Based Devices
Published in Neil S. Sadick, Illustrated Manual of Injectable Fillers, 2020
IPL devices emit light between 500 and 1200 nm using a noncoherent and broad-spectrum wavelength filtered light source (11). Despite its broad spectrum, IPL can be modified to a specific wavelength range through the use of cut-off filters, thereby improving target selectivity. IPL is effective in treating features of photoaging by targeting both vascular lesions and pigmented lesions through photothermolysis of oxy/deoxyhemoglobin and melanin, respectively (12,13). In addition to improving cutaneous signs of solar elastosis, IPL has also been shown to stimulate dermal collagen production through the upregulation of procollagen 1 and 3 and downregulation of proteolytic enzymes like matrix metalloproteinases 1 and 2 (13–17). Adverse effects are generally mild and temporary following IPL treatment. Minor crusting and erythema should be anticipated, while purpura and striping of untreated areas are rarely seen (11,18). Furthermore, if appropriate precautions (e.g., longer interpulse delays, higher cut-off filters) are not taken in patients with darker skin types, residual dyschromia can occur (19).
Psoriasis
Published in Nilton Di Chiacchio, Antonella Tosti, Therapies for Nail Disorders, 2020
Stamatis Gregoriou, Eftychia Platsidaki, Dimitris Rigopoulos
Intense pulsed light treatment can be considered a promising effective and safe treatment modality. In a study, 20 patients were treated with IPL every 2 weeks for 6 months, demonstrating nail bed improvement by 71.2% and nail matrix by 32.2%.21
Botulinum toxin used in conjunction with other injectables and devices for cosmetic purposes
Published in Anthony V. Benedetto, Botulinum Toxins in Clinical Aesthetic Practice, 2017
Alastair Carruthers, Jean Carruthers
A nonablative, broadband light source that emits a continuous spectrum ranging from 500 to 1200 nm, intense pulsed light selectively targets microvasculature and melanin components within the dermis by particular wavelengths and pulse durations while sparing the epidermis from thermal injury. The emitted heat improves hyperpigmentation through the destruction of melanin and hemoglobin and stimulates the formation of new collagen for positive changes in skin texture.27 IPL is used for the treatment of photodamaged skin, reducing both lentigenes and vascular lesions, such as telangiectasias, port-wine stains, and poikiloderma, and improving skin texture, pore size, and fine wrinkles.28,29 Results are often subtle and require multiple treatment sessions, and fine lines appear to respond better than deeper lines and furrows.30
The Approach of Intense Pulsed Light Treatment in Patients with Different Severities of Meibomian Gland Dysfunction
Published in Current Eye Research, 2023
Three IPL treatments were given once monthly for a total of three treatments in IPL Group1 and IPL Group2. A modular laser multi-application platform (M22, Lumenis, Yokneam, Israel) was used. Light pluses were conducted two times from the left preauricular area, across the cheeks and nose, to the right preauricular area, with slightly overlapping areas of application. IPL treatment intensity was chosen based on the Fitzpatrick scale and patients’ endurance. Lower energy levels (range of 13–18 J/cm2) and a higher filter amount (560 or 590 nm) were applied on patients with higher Fitzpatrick scale values and less endurance. Other routine safety requirements of IPL treatment were also followed: (1) Patients were requested to wearing opaque goggles and closing their eyes strictly during IPL procedure; (2) Patients were suggested to use ice compress 10–15 min after the treatement procedure instantly; (3) Sun protection was required for one month after each IPL procedure.
Efficacy of five-flash intense pulsed light therapy technique in patients with meibomian gland dysfunction
Published in Clinical and Experimental Optometry, 2022
Siamak Zarei-Ghanavati, Samira Hassanzadeh, Abbas Azimi Khorasani, Asieh Ehsaei, Elham Bakhtiari
No adverse effects were found among the participants throughout the study. Studies report no major adverse effects following IPL therapy. The clinical safety of IPL therapy has been confirmed especially with proper protection of globe and eyelid during treatment.9,28 The results showed consistent objective and subjective clinical improvements of ocular surface parameters from day 0 up to day 75 (1 month after the last session). In both study groups, the OSDI score, NIKBUT, FTBUT, MG expressibility, meibum quality score, and tear osmolarity improved significantly over time. The treatment effect of IPL was significant for ocular hyperaemia. During follow up sessions an improvement in tear film stability was observed and the mean NIKBUT increased by 5.7 seconds in the IPL group, while the OSDI score decreased by 26.5 points. In the control group, an improvement of 4.1 seconds in NIKBUT and 23.1 points on the OSDI score was observed. According to previous studies, an increase of more than 4 seconds in NIKBUT and/or a reduction of more than 4.5 points in the OSDI score is considered a treatment success.29,30 However, we used a modest treatment technique with the lack of mechanically MG expression post-IPL treatment.
Demodex and eye disease
Published in Clinical and Experimental Optometry, 2021
Intense pulsed light (IPL) is used in a variety of medical and aesthetic skin conditions.142 It has shown promising results in demodicosis management,143–145 including in rosacea patients143 and for ocular infestation.144 One study, performing IPL three times (baseline, at 30 and 90-days) determined a Demodex eradication rate of 55 per cent with IPL at one-month and a significant improvement in tear break‐up time, meibum quality and Ocular Surface Disease Index (OSDI) score after three-months in favour of IPL.145 At this time the exact mechanism explaining the IPL effect on Demodex has yet to be fully elucidated; however, it has been suggested that Demodex mites may be sensitive to the energy delivered during IPL and/or the heat generated which may elevate the temperature to critical levels to eradicate them.146 Real‐time video post in vitro IPL revealed temperatures of a microscope slide reaching 49°C with complete immobilisation of the mite (retraction and no movement of the legs) within 25-seconds following IPL.147 This phenomenon warrants further clinical investigation.