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Fungal Lipids
Published in Rajendra Prasad, Mahmoud A. Ghannoum, Lipids of Pathogenic Fungi, 2017
Compounds closely related to fatty acids also occur, e.g., long-chain fatty aldehydes and, among secondary metabolites, the large class of polyketides,4,5 derived from acetate. A series of long-chain fatty aldehydes, previously not known in fungi, was isolated by Stoessl from cultures of Cercospora arachidicola growing on potato dextrose agar and shown to consist predominantly of penta- and hexadecanal and heptadec-8-enal, with small or trace amounts of tetra-, hexa- and nonadecenal, tetra-, penta-2-, and penta-dec-6-enal as well as heptadec-8,11-dienal, together with a mono- and a di-unsaturated C16 aldehyde.54
Pentadecanal inspired molecules as new anti-biofilm agents against Staphylococcus epidermidis
Published in Biofouling, 2018
Annarita Ricciardelli, Angela Casillo, Rosanna Papa, Daria Maria Monti, Paola Imbimbo, Gianluca Vrenna, Marco Artini, Laura Selan, Maria Michela Corsaro, Maria Luisa Tutino, Ermenegilda Parrilli
In a previous paper, the specificity of the pentadecanal action on S. epidermidis biofilm was explored by testing chemical analogues differing either in the length of the aliphatic chain or in their functional group properties (Casillo et al. 2017). In particular, similar aldehydes and corresponding alcohols, characterized by different lengths of the aliphatic chain (C-14/C-20), were analysed, and the results demonstrated that both the length of the aliphatic chain and the functional group properties were important for the pentadecanal activity against S. epidermidis biofilm (Casillo et al. 2017). Since the hexadecanal and the tetradecanal did not show anti-biofilm activity (Casillo et al. 2017), whereas the pentadecanol showed a slight but significant activity, the new anti-biofilm molecules were designed preserving the length of the aliphatic chain and modifying the functional group.
FAM19A5/S1PR1 signaling pathway regulates the viability and proliferation of mantle cell lymphoma
Published in Journal of Receptors and Signal Transduction, 2022
Yanfang Wang, Zhenhao Zhang, Wei Wan, Yan Liu, Hongmei Jing, Fei Dong
S1P is a sphingolipid amphiphilic molecule containing a serine polar head group, which is produced by phosphorylation of sphingosine by sphingosinekinase (SPHK). S1P can be decomposed into phosphatidylethanolamine and palmitaldehyde (hexadecanal) by S1P lyase, or by S1P phosphoric acid