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Aetiology and Laboratory Diagnosis
Published in Raimo E Suhonen, Rodney P R Dawber, David H Ellis, Fungal Infections of the Skin, Hair and Nails, 2020
Raimo E Suhonen, Rodney P R Dawber, David H Ellis
Geotrichum candidum A rare opportunistic pathogen causing bronchial and pulmonary infections; oral, vaginal, cutaneous and gastrointestinal infections are also reported. This is a common fungus with a worldwide distribution.
Epidemiology of fungal infections: What, where, and when
Published in Mahmoud A. Ghannoum, John R. Perfect, Antifungal Therapy, 2019
Frederic Lamoth, Sylvia F. Costa, Barbara D. Alexander
Geotrichum candidum is a filamentous yeast forming arthroconidia that colonizes the gastrointestinal and respiratory tract. Although G. candidum is frequently encountered in stool specimens of onco-hematological patients receiving azole prophylaxis [499], it rarely causes invasive disease. In a review of 12 cases of Geotrichum disseminated infections reported in the literature from 1971 to 2007, 8 (67%) occurred in patients with underlying malignancies [500]. Fungemia was present in 7 (58%) cases. Other infection sites included lungs, gastro-intestinal tract, liver, spleen, kidney, brain, lymph nodes, bone marrow and skin.
Arabian Primrose leaf extract mediated synthesis of silver nanoparticles: their industrial and biomedical applications
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2020
Shruti Nindawat, Veena Agrawal
The present study for the first time reports rapid, economically efficient, facile and eco-friendly method for the synthesis of Ah-AgNPs using aqueous leaf extract of Arnebia hispidissima. Such nanoparticles have shown strong anti-oxidant activity, catalytic degradation potential for the tested anthropogenic dye pollutants, excellent selective and sensitive detection of metal ions (Fe3+, Hg2+), ammonia; anti-cancerous and anti-microbial activities. Also, the biogenic Ah-AgNPs developed herein for the first time exhibited significantly high anti-fungal activity against Geotrichum candidum, a fungus known to infect immunocompromised patients. Consequently, such green synthesis of silver metal-based nanoparticles using medicinal plants is pharmacologically and industrially significant and will set a new standard for their large scale synthesis and application in plethora of fields.
Fabrication of silver nanoparticles using Arnebia hispidissima (Lehm.) A. DC. root extract and unravelling their potential biomedical applications
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Shruti Nindawat, Veena Agrawal
The antifungal and antibacterial susceptibility pattern was evaluated using agar based well diffusion method. The activity of AHAgNPs was tested against the fungal strains namely Candida tropicalis (ATCC 750), C. albicans ATCC 24433, Geotrichum candidum ATCC 7115 and the bacterial strains were Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC 13883), Enterococcus faecalis (ATCC 29212) and Staphylococcus aureus (ATCC 25923). Mueller-Hinton agar medium supplemented with 2% glucose was used. The inoculum suspension was made by adjusting it to 0.5 McFarland standard i.e. 106 cells/mL. Sterile swab was dipped into the inoculum suspension and the agar plates were inoculated by streaking it along the agar surface in all directions spreading it as a lawn culture. A hole (diameter 8 mm) was punched aseptically using a sterile cork borer, and 100 µL of AHAgNPs and AHRE (0.125, 0.25, 0.5, 1 mg/mL) was introduced into the well. Plates were then incubated at 37 °C for 24 h till visible growth was seen. Amphotericin B was used as positive control for anti-fungal tests whereas amikacin, vancomycin and piptaz were used as positive controls for anti-bacterial tests. After incubation, the zone diameter endpoints were read at complete inhibition for all the treatments.
Saprochaete clavata Chorioretinitis in a Post-chemotherapy Immunocompromised 9-Year-Old Child
Published in Ocular Immunology and Inflammation, 2023
Paul Goupillou, Damien Costa, Gilles Gargala, Loic Favennec, Claire Rouzaud, Marc Muraine, Pascale Schneider, Julie Gueudry
Former studies have found rates of endogenous endophthalmitis ranging from 0% to 37% in patients with fungaemia, more frequently candidemia.15 To date, no ophthalmological lesions have been documented with Saprochaete clavata: to the best of our knowledge, our case of bilateral chorioretinitis is the first reported in the literature. We found very few cases of ocular involvement with Geotrichum species. There was one case of postoperative endophtalmitis with Geotrichum candidum16 and one case of endogenous endophtalmitis treated with both intravenous and intravitreal VCZ.17 Some keratitis with Geotrichum capitatum (now called Magniscyomyces capitatus) have also been reported.18