Contact-dependent growth inhibition

Pili and Hosts

Published in Paul Pumpens, Single-Stranded RNA Phages, 2020

An exhaustive review on the conjugative pili and their phages was published by Arutyunov and Frost (2013). Remarkably, the phage R17 was involved in the recent study that unveiled the novel role of F pili by the import of contact-dependent growth inhibition toxins (Beck et al. 2014).

The evolution and competitive strategies of Akkermansia muciniphila in gut

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Journal Information

Published in Gut Microbes, 2022

Ji-Sun Kim, Se Won Kang, Ju Huck Lee, Seung-Hwan Park, Jung-Sook Lee

In most bacterial genomes, transposable elements are usually responsible for a high level of gene turnover (outlier events). However, wapA, a gene encoding wall-associated protein A, was recognized as an outlier in A. muciniphila strains. Interestingly, it occurred in the internal branch evolving from the MRCA to group A, which means that the addition of wapA gene may be an important driving force of the evolution of group A. Rearrangement hotspot (Rhs) and related YD-peptide repeat proteins are widely distributed in bacteria and eukaryotes. It has been reported that Rhs (Rearrangement hotspot) proteins are found in gram-negative bacteria and WapA proteins are present in gram-positive bacteria.44,45 Although WapA proteins have not been assigned a definitive function, it has recently been reported that these proteins are involved in intercellular competition via contact-dependent growth inhibition.44,45

Contact-dependent growth inhibition

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Pili and Hosts

The evolution and competitive strategies of Akkermansia muciniphila in gut