China
Africa
Explore chapters and articles related to this topic
Wilson's Disease
Published in Charles Theisler, Adjuvant Medical Care, 2023
Diet: Patients should generally avoid eating foods with a high copper content, such as liver, chocolate, nuts, mushrooms, legumes, and shellfish (especially lobster). Drinking water from atypical sources (e.g., well water) should be analyzed for copper content and replaced with purified water if the copper content is greater than 0.2 parts per million.3
Hazard Analysis and Critical Control Point (HACCP) Protocols in Cosmetic Microbiology
Published in Philip A. Geis, Cosmetic Microbiology, 2020
Laura M. Clemens, Harry L. Schubert
A CIP system was utilized to introduce purified water into a process system for purposes of cleaning and sanitization. The CIP system was not drainable, not sanitary, and not monitored for integrity against microorganisms during use. The system became heavily contaminated and was inoculating the process system during cleaning and sanitization.
Commercial Scale Manufacturing of Oligonucleotides Under Good Manufacturing Practices
Published in Eric Wickstrom, Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors, 2020
Jose E. Gonzalez, Richard G. Einig, Patricia Puma, Timothy P. Noonan, Paul E. Kennedy, Bruce G. Sturgeon, Bing H. Wang, Jin-yan Tang
Separate air handlers are used for the manufacturing suites to prevent any possibility of cross contamination. The manufacturing areas are classified under FED STD 209E and are routinely monitored. This is a U.S. government standard for airborne particulate cleanliness classes in clean rooms and clean zones. City supplied water is used as a feed water for the RO/DI system. This water is processed to produce water that exceeds the USP requirements for "Purified Water". It is then used for non-critical processing and as feed water for a Water for Injection, USP (WFI) system. The WFI water is delivered to points of use via a constantly circulating hot loop. Both the RO/DI and the WFI water are monitored frequently during the week, so that all points of use and critical areas before and after filters are tested.
Comparative study on the performance of monoolein cubic nanoparticles and trimyristin solid lipid nanoparticles as carriers for docetaxel
Published in Pharmaceutical Development and Technology, 2023
Mohamed Dawoud, Mariam Mojally, Randa Abdou, Hany G. Attia
The triglyceride trimyristin (D114, Dynasan 114) was obtained from (Condea, Germany), monoolein (GMOrphic-801) was purchased from Eastman Chemical Company (Kingsport, TN), Poloxamer 188 (F68, Lutrol F68) and poloxamer 407 (Lutrol F127) were bought from BASF AG (D-Ludwigshafen), diethylaminoethyl (DEAE) Sepharose CL-6B Amersham Biosciences AB (S-Uppsala), lipoid S75 (Lipoid GMBH, D- Ludwigshafen), Trizma 7.4 pre-set crystals, sucrose, sodium azide and MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide) were purchased from Sigma Chemical company (ST. Louis,M.O, USA). Acetonitrile, methanol, and chloroform were bought from VWR International (D-Darmstadt). The cell lines were purchased from ATCC, USA. All cell culture materials were purchased from Lonza Bioscience (Morristown, USA). Purified water was prepared by filtration and deionization/reverse osmosis (Milli RX 20, Millipore, D-Schwalbach).
The electronic tongue: an advanced taste-sensing multichannel sensory tool with global selectivity for application in the pharmaceutical and food industry
Published in Pharmaceutical Development and Technology, 2023
The system’s sensors can only recognize a standard set of tastes that have already been entered into the database (Munekata et al. 2023).The sensors are capable of accurately identifying the flavour of the sample, but they are unable to perfectly replicate the sophisticated human olfactory system. Similar to human senses, artificial senses cannot be integrated simultaneously (Schlossareck and Ross 2019).The device’s durability is also a problem because of the sensors it uses, which shortens its lifespan. Additionally, some of the market’s sensors are expensive (Del Valle 2012).As long as a sample is liquid, it can be measured. We often dissolve API or the medication being tested in 10mM KCl solution to give it some conductivity. Purified water is typically used to dissolve or combine with food samples during food testing to remove the flavour. Oil should be removed to less than 2% for the best sensor conditions (Anjiki et al. 2011).
Thermosensitive gel based on cellulose derivative for topical delivery of propolis in acne treatment
Published in Pharmaceutical Development and Technology, 2022
Fernanda Belincanta Borghi-Pangoni, Jéssica Bassi da Silva, Rafaela Said dos Santos, Ana Paula Trevisan, Francyelle Carolyne de Castro Hott, Marcelly Chue Gonçalves, Renata Katsuko Takayama Kobayashi, Maria Vitória Felipe de Souza, Marcia Edilaine Lopes Consolaro, Lidiane Vizioli de Castro-Hoshino, Mauro Luciano Baesso, Marcos Luciano Bruschi
The in vitro analysis of PES release from the systems was performed using a vertical diffusion cell apparatus (modified Franz’s cell), containing cellulose acetate membrane as support (pore size 0.45 mm; MW cut-off 12 400 kDa) (Pereira et al. 2013; Villa Nova et al. 2014). The cells were equipped with a sample receiving site of 1 cm in diameter (0.78 cm2 of exposure area), which is directly in contact with the receiving phase. The release medium was purified water (20.0 ml), at 37 ± 0.5 °C, and under constant magnetic agitation (Fabri et al. 2011). PES [2.0 ml dispersed in purified water (1:1)] or 2.0 g of formulation (dispersed in 1 ml of purified water) was placed in the donor chamber, sink conditions were guaranteed, and 1.0-ml aliquots of the medium were withdrawn at 0.5, 1, 2, 3, 4, 6, and 8 h, with dissolution medium reposition. The collected samples were analyzed as TPC, according to the Folin-Ciocalteau method, with minor modifications (de Francisco LMB et al. 2018). The sample (1.0 ml) was mixed with 10 ml of purified water, and 1.0 ml of Folin-Ciocalteau reagent, and the volume was made up of 25 ml with an aqueous solution of Na2CO3 (14.06%, w/v). After 15 min, the absorbance was measured using a UV-1800 spectrophotometer (Shimadzu, Tokyo, Japan) at the wavelength (λ) of 760 nm. Purified water was utilized as a compensatory solution. The analytical curve of gallic acid was also utilized, as previously described for PE characterization. At least three replicate samples were analyzed.