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Bio-Implants Derived from Biocompatible and Biodegradable Biopolymeric Materials
Published in P. Mereena Luke, K. R. Dhanya, Didier Rouxel, Nandakumar Kalarikkal, Sabu Thomas, Advanced Studies in Experimental and Clinical Medicine, 2021
Polybutylene succinate (PBS based different blends are tried gave greater toughness. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and poly(butylene succinate-co-adipate) (PBSA) biodegradable polymers some of them [39]. These polymers were added to a PLA/PBAT blend giving a decrease of thermal properties. There is an observation of an increase in melt flow with PBS, as it is more flexible compared to the other. There is no change in melt flow observed with PBSA or PHBV [40]. PLA degrades into water and carbon dioxide that does not cause any harm; they can be cleared out of human body, thus PLA became the most popular biomedical material in the market.
Polymeric Colloidal Carriers for Natural Polyphenolic Compounds
Published in Madhu Gupta, Durgesh Nandini Chauhan, Vikas Sharma, Nagendra Singh Chauhan, Novel Drug Delivery Systems for Phytoconstituents, 2020
Maria Rosaria Lauro, Teresa Musumeci, Francesca Sansone, Giovanni Puglisi, Rosario Pignatello
In recent years, different authors have developed colloidal carriers to protect and control the release of polyphenols using aliphatic polyesters, which can be of microbial origin or obtained by chemical synthesis. They include poly-lactide (PLA), poly (lactide-co-glycolide) (PLGA), poly-ε-caprolactone (PCL), polyhydroxyalkanoates (PHAs), and their copolymers and derivatives. Due to their controlled delivery properties, biodegradability, and biocompatibility, their application is of great interest to the biomedical field. These polymers show ideal features for encapsulating lipophilic compounds. Biodegradable polyesters can be classified with regard to the mode of bonding of the constituent monomers: (i) poly (hydroxy acid)s with –O–R–CO– as repeating monomeric units, such as poly (3-hydroxybutyrate) [P (3HB)], PLA, poly (glycolic acid) (PGA), PCL, etc.; and (ii) poly (alkylenedicarboxylate)s, i.e., poly (ethylene succinate) (PESu), poly (butylene succinate) (PBSu), poly (ethylene adipate) (PEA), and poly (butylene adipate) (PBA). Biodegradable polyesters can be further split into two groups: (i) biomass-based polyesters (microbial origin), such as PLA, P (3HB), and their copolymers, and (ii) petroleum-based aliphatic polyesters such as PGA, PCL, PBA, poly (3-hydro propionate) (PHP), and PBSu. Synthetic polymers offer the advantage of higher purity and reproducibility with respect to natural polymers. Conversely, polyesters from microbial origin can be produced from renewable raw materials, thus playing a potential role in environmentally-friendly industry and green chemistry strategies (Chanprateep, 2010).
Understanding the basis of medical use of poly-lactide-based resorbable polymers and composites – a review of the clinical and metabolic impact
Published in Drug Metabolism Reviews, 2019
Sergiu Vacaras, Mihaela Baciut, Ondine Lucaciu, Cristian Dinu, Grigore Baciut, Liana Crisan, Mihaela Hedesiu, Bogdan Crisan, Florin Onisor, Gabriel Armencea, Ileana Mitre, Ioan Barbur, Winfried Kretschmer, Simion Bran
Other biodegradable polyesters in use are:PHA – polyhydroxyalkanoatesPHH – polyydroxyhexanoatesPHB – polyhydroxybutyratePHV – polyhydroxyvaleratePCL – polycaprolactonePBS – polybutylene succinatePBSA – polybutylene succinate adipateAAC – aliphatic–aromatic copolyestersPET – polyethylene terephthalatePBAT – polybutylene adipate/terephthalatePTMAT – polymethylene adipate/terephthalate (Nampoothiri et al. 2010)
Combined chemo/photothermal therapy based on mesoporous silica-Au core-shell nanoparticles for hepatocellular carcinoma treatment
Published in Drug Development and Industrial Pharmacy, 2019
Jian Wang, Yamin Zhang, Lei Liu, Zilin Cui, Xiaolong Liu, Lianjiang Wang, Yang Li, Qiang Li
SO-MSNs and SO-Au-MSNs were dispersed in poly butylene succinate (PBS) (pH = 7.4) and transferred to dialysis bags (MWCO:2000 Da) [14]. To study the effect of laser on release profiles, SO-MSNs and SO-Au-MSNs were irradiated by an 808 nm laser before transferring to dialysis bags, followed by immersing in centrifuge tubes containing 30 ml of PBS and stirred at 100 rpm. The PBS outside the dialysis bags was replaced with fresh PBS. The concentration of SO in collected release medium was determined by using UV spectrophotometer.
Role of STRO-1 sorting of porcine dental germ stem cells in dental stem cell-mediated bone tissue engineering
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Gorke Gurel Pekozer, Mustafa Ramazanoglu, Karl Andreas Schlegel, Fatma Nese Kok, Gamze Torun Kose
Tooth germ stem cells isolated from porcine third molars and their characterization and differentiation depending on their STRO-1 expression were first reported in detail in this paper. pTGSCs, which were isolated for this study, were also used for bone tissue engineering on fibronection or laminin-modified poly(butylene succinate) (PBS) scaffolds simultaneously with this study [12].