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Common Medicines from Herbs, Minerals and Animal Sources
Published in Mehwish Iqbal, Complementary and Alternative Medicinal Approaches for Enhancing Immunity, 2023
Various analytical processes have identified nearly 115 constituents of dried and fresh ginger. Nearly 31 gingerol-associated constituents have been discovered from the crude alcoholic extracts of fresh rhizome of ginger (Jiang et al., 2005). Ginger has been divided into at least 14 bioactive constituents, including [8]-gingerol, methoxy-[10]-gingerol, [6]-shogaol, [6]-paradol, hexahydrocurcumin, 1-dehydro-[10]-gingerdioen, [14]-shogaol, [4]-gingerol, [10]-gingerdione, [6]-gingerol, tetrahydrocurcumin, [10]-gingerol, 1,7-bis-(4′hydroxyl-3′methoxyphenyl)-5-methoxyhepthan-3-one and gingerenone A (Koh et al., 2009).
Tropical Herbs and Spices as Functional Foods with Antidiabetic Activities
Published in Megh R. Goyal, Arijit Nath, Rasul Hafiz Ansar Suleria, Plant-Based Functional Foods and Phytochemicals, 2021
Arnia Sari Mukaromah, Fitria Susilowati
Ginger (Zingiber officinale Roscoe) is similar to turmeric and it is a popular ingredient in cooking due to a peculiar flavor, aroma, and pungent odors. Besides cooking, ginger is also well-known for its medicinal properties against gastrointestinal disorder, motion sickness, nausea relief, cold, and flu relief, pain, and inflammation (reduce muscle pain, knee, and elbow). Ginger contains several biochemical constituents, such as: gingerol, shogaol, paradol, and zingerone [23]. It may also reduce the risks of cardiovascular diseases (CVDs), blood clotting, and hyperglycemia.
Paradol Induces Cell Cycle Arrest and Apoptosis in Glioblastoma Cells
Published in Nutrition and Cancer, 2022
Rui Wang, Tingting Liu, Jiayu Chen, Dianbao Zhang
GBM is the most frequent and lethal primary brain tumor. The median survival rate for patients with GBM has remained unchanged for almost 20 years (15). The bleak prognosis and long-term survival of GBM patients are due to relapse and high resistance to conventional therapies (16). Therefore, the development of novel therapeutic strategies is urgently required. Paradol, a flavor phenolic compound found in ginger and pepper, has been reported to display various bioactivities, including antioxidative, anti-inflammatory, and anti-tumor activities (17). Paradol has been recently shown to display anti-inflammatory and antioxidative activities in acetic acid-induced ulcerative colitis and ear edema in mice (5,8). Paradol has also been recognized as a potential therapeutic agent in the treatment of cerebral ischemia by reducing neuroinflammation (18). In addition, paradol improved osteoporosis, painful diabetic neuropathy, and memory disorders in mice (19–21). Paradol also exhibited anti-tumor activities in several cancer cells, including promyelocytic leukemia, oral squamous carcinoma, melanoma, lung cancer, breast cancer, buccal pouch carcinogenesis, and hepatocellular carcinoma cells (6–12). The antitumor effects of paradol might be mediated by cytokine expression, reactive oxygen species generation, and various signaling pathways (22). In this study, we showed that paradol effectively inhibited the viability and migration of GBM cells in a dose- and time-dependent manner by inducing cell cycle arrest and apoptosis that was potentially mediated via the activation of the MAPK signaling pathway.
Vanillin enones as selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII. The out of the active site pocket for the design of selective inhibitors?
Published in Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Leonardo E. Riafrecha, Macarena S. Le Pors, Martín J. Lavecchia, Silvia Bua, Claudiu T. Supuran, Pedro A. Colinas
The intake of protective factors for fortifying the natural bodýs defense capacity to reduce the risk of cancer is an approach called chemoprevention. Recently natural products containing phenols, have been recognised as cancer chemopreventive agents6–8. Ginger (Zingiber officinale) is one of the most widely consumed spices in the world6,7 Ginger contains several phenolic compounds possessing antimicrobial and analgesic activity, such as 6-gingerol and 6-paradol that incorporate vanillin (4-hydroxy-3-methoxyphenyl) moiety in their molecules. Related 6-dehydroparadols have shown antitumor-promoting activity in mouse skin carcinogenesis9. 6-Shogaol, another vanillin derivative found in ginger, suppresses the proliferation of non-small cell lung cancer9. Phenol derivatives, including some natural products, have also been studied as CA inhibitors (CAIs)10–13.