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Fibroids in Pregnancy
Published in Botros R.M.B. Rizk, Yakoub Khalaf, Mostafa A. Borahay, Fibroids and Reproduction, 2020
Pain may be managed with a short course of ibuprofen [10]. Indomethacin 25 mg orally every 6 hours for up to 48 hours is another NSAID that has been effective [11]. Therapy should be limited to pregnancies less than 32 weeks of gestation because of the possibility of inducing premature closure of the ductus arteriosus, neonatal pulmonary hypertension, oligohydramnios, and fetal/neonatal platelet dysfunction [11]. If indomethacin is continued for more than 48 hours, weekly sonographic assessment for oligohydramnios and narrowing of the fetal ductus arteriosus should be performed. If either of these findings is noted, indomethacin should either be discontinued or reduced to 25 mg every 12 hours. Repeat courses can be given as needed for recurrent episodes of pain. Although first-trimester use of NSAIDs has been associated with miscarriage in some studies, the best data do not support an association [33]. The use of a local protected heating pad may be safer for the pregnancy if the patient tolerates its use and is less ambulatory.
Cross Talk Between Heat Shock and Oxidative Stress Inducible Genes During Myocardial Adaptation to Ischemia
Published in John J. Lemasters, Constance Oliver, Cell Biology of Trauma, 2020
Dipak K. Das, Nilanjana Maulik
Hearts can be adapted by subjecting them to direct heat shock. Among many methods, the one most commonly used consists of allowing the animals to swim in warm water to raise their body temperature.30 In some studies, animals were heated using an electric blanket or heating pad.31 In the case of isolated heart, the heart can be directly heated by being perfused with warm buffer or blood.29 Recently a novel approach was used in the authors’ laboratory to induce the heat shock.32 A sympathomimetic drug, amphetamine, was used to raise the body temperature. Rats were injected with amphetamine sulfate (3 mg/kg, i.m.), and the rectal temperature was monitored. The control animals (n = 6) received saline injection only. The rectal temperature of rats before amphetamine injection ranged from 37 to 38°C. After 1 h of amphetamine injection, the rectal temperature increased markedly in the range of 41.5 to 42.5°C. This hyperthermic state lasted for up to 3 h, then it gradually returned to the basal temperature in another 3 to 4 h. Forty hours after the injection, the animals were anesthetized with an intervaneous injection of sodium pentobarbital (Nembutal, 25 mg/ml), and the isolated perfused heart was prepared as described above. Both control and experimental hearts were subjected to 30 min of ischemia followed by 60 min of reperfusion.
When I Control the Pain, I Control My Life: Opioids and Opioid-Containing Analgesic Medication in the Management of Chronic Intractable Pain
Published in Michael S. Margoles, Richard Weiner, Chronic PAIN, 2019
In early February 1979, I was in the crash landing of a small plane near Palmdale, CA. We were all able to leave the scene without assistance, but my back and right hip really hurt, and the pain worsened over the next few days. I tried heat and stretching, but when those did nothing, I sought the help of a chiropractor again. Unfortunately, his manipulations did nothing, but when he X-rayed my back, he noticed what he called “bone spurs” and he set me up for a course of treatment. When I got home from the first session with him, I stooped down to get something from the bottom drawer of my dresser and I was unable to straighten up. The pain was sharp and excruciating. I called my family physician, who saw me right away, but only said that it would take about 2 weeks for the pain to go away. He just said I was getting old (she was age 27 then). He told me to use a heating pad for 20 minutes at a time every hour and to stay in bed. At the end of the 2 weeks, during which time he had also given me Talwin® for pain relief and to relax me, the pain was still the same as when I first called him. I was anxious to get back to work, so he recommended that I see a specialist, as he (my family physician) did not want to continue to treat what was becoming a chronic condition. He said there were advances being made in the treatment of back pain, and he had recently spoken with a doctor who he thought could help me. Dr. Michael Margoles is the doctor my family physician sent me to. I was in some of the worst pain I had ever felt and called for an appointment right away…
Dihydromyricetin alleviates cerebral ischemia-reperfusion injury by attenuating apoptosis and astrogliosis in peri-infarct cortex
Published in Neurological Research, 2022
Himika Wasan, Devendra Singh, Balu Joshi, Deepti Upadhyay, Uma Sharma, Amit Kumar Dinda, K. H. Reeta
The MCAo model in rats was established as per the protocol suggested by Longa et al [20], with slight modifications. Briefly, rats were anesthetized with isoflurane (5% for induction followed by 3% for maintenance). The surgical table was disinfected, and a thermostatically regulated heating pad was used for maintaining body temperature during surgery. The surgical site was shaved, cleaned, and disinfected with povidone iodine solution and 70% ethanol. A midline neck incision was made; common, external, and internal carotid arteries were isolated and cleaned. External carotid artery was tied, and a nick was given, into which a silicon-coated monofilament (Doccol suture, catalogue no: 403723PK10Re) was inserted and advanced into the internal carotid artery toward middle cerebral artery until a resistance was felt. Around 20–22 mm length of the filament was inserted. The filament was kept in place for 90 min and removed gently thereafter, and the surgical site was sutured. Rats were kept in their home cages and observed until they gained righting reflex. Drugs and vehicle were administered as per the protocol, and rats were sacrificed after 72 h. In the sham group, all surgical steps were followed except filament insertion.
Vanillic acid attenuates amyloid β1-40-induced long-term potentiation deficit in male rats: an in vivo investigation
Published in Neurological Research, 2021
Nesa Ahmadi, Naser Mirazi, Alireza Komaki, Samaneh Safari, Abdolkarim Hosseini
Anesthetization of animals was done via the IP injections of urethane (ethyl carbamate; Sigma, USA; 1.5 g/kg through supplementary insertion as required) [18]. To maintain the body temperature of the animals, a heating pad was utilized. Having done the skin incision and having been assigned the dentate gyrus (DG) position based on the atlas for brains of the rat [17], we drilled small burr holes into the skulls. We positioned the stimulating and recording electrodes in the DG (dorsoventral (DV): 2.7–3.2 mm from the surface of the skull; anteroposterior (AP): −3.8 mm from the bregma; mediolateral (ML): 2.3 mm from the midline) and perforant pathway (PP) (DV: 3.2 mm from the skull’s surface; AP: −8.1 mm from the bregma; ML: 4.3 mm from the midline). The best possible optimum result in the ventral placement was attained through an electrophysiological monitor of the response evoked in DG, which followed the single-pulse PP stimulations. Due to the decrease and low chance of occurrence of each trauma to the brain tissue, the electrodes were lowered very smoothly and cautiously from the cortex to the hippocampus (0.2 mm/min) [5].
Modeling of heat transfer and thermal regulation for an electric heating glove against a cold environment
Published in International Journal of Occupational Safety and Ergonomics, 2023
Na Xu, Guangju Liu, Yun Su, Miao Tian, Jun Li
In addition, the heating pad would always heat to maintain the skin temperature when the pressure increased to a certain value, thus the power consumption of the heating pad would not change much. The power consumption of the heating pad increased when pressure was applied at first, but the rate of increase would gradually reduce as the pressure increased. When the heating pad needed to heat all of the time, the power consumption no longer changed. It could be seen that when the heat generated by the heating pad could keep the temperature of skin stable at 35 °C, the increase of the pressure had little impact on the cold-proof performance and power consumption of the electric heating glove.