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N-butyl cyanoacrylate versus Onyx embolotherapy
Published in Byung-Boong Lee, Peter Gloviczki, Francine Blei, Jovan N. Markovic, Vascular Malformations, 2019
Cyanoacrylate glues are liquid alkyl-2-cyanoacrylate monomers that, on contact with ionic mediums (e.g., water, blood), form flexible polymers with strong adhesive bonds to soft tissues. These liquid monomers in isolation are nonviscous, radiolucent, and rapidly polymerize. Consequently, they are combined as a two-component embolic agent with either tantalum powder or ethiodized oil (Lipiodol; Andre Guerbet, Aulnay-sous-Bois, France). The added agent prolongs polymerization time, opacifies the liquid agent, and allows for its visualization under fluoroscopy. The NBCA mixture ratio is also guided by the polymerization times described by Pollak and White, who suggested that the estimated in vivo polymerization time for NBCA to iodize oil mixtures between 1:1 and 1:4 was 1–4 seconds, with a linear relationship between time and mixture ratio.2, 6, 9
Topical Therapy: Cyanoacrylates and Other Modalities
Published in John P. Papp, Endoscopie Control of Gastrointestinal Hemorrhage, 2019
Considerable interest in clinical and experimental medicine has been raised by tissue adhesives since the synthesis of cyanoacrylate analogs.56-58 The structural formula of these compounds is shown below:
Hair Morphology, Biogenesis, Heterogeneity, Pathophysiology and Hair Follicle Penetration
Published in Heather A.E. Benson, Michael S. Roberts, Vânia Rodrigues Leite-Silva, Kenneth A. Walters, Cosmetic Formulation, 2019
Alexa Patzelt, Jürgen Lademann
Differential stripping represents a valuable method to investigate the follicular penetration, however, without considering the transfollicular penetration process (Teichmann et al., 2005). Differential stripping is a combined method of tape stripping and cyanoacrylate skin surface biopsy. After topical application and penetration of a substance, the stratum corneum is removed by tape stripping. Subsequently, the substance is only located in the hair follicles, and the follicular content can be removed by cyanoacrylate skin surface biopsy. This method allows the quantitative analysis of the amount of substance penetrated into the stratum corneum and the hair follicles. This method can be applied to in vivo and ex vivo skin models. However, it has to be taken into consideration that the follicular reservoir is significantly reduced by 90% in excised human skin due to skin contraction occurring after skin excision (Patzelt et al., 2008). In porcine ear skin, hair follicles are fixed more tightly within the skin and cannot be removed completely by cyanoacrylate skin surface biopsies, which likewise has to be considered during quantification.
Design and development of essential oil based nanoemulsion for topical application of triclosan for effective skin antisepsis
Published in Pharmaceutical Development and Technology, 2022
Pratibha G. Kakadia, Barbara R. Conway
At the end of the permeation study, the amount of TSN retained within the skin was quantified using the adhesive tape stripping method. After 24 h of diffusion, the skin was carefully removed and washed with distilled water to remove any residual formulation. A differential stripping technique was used to quantify the amount of TSN in porcine skin by combining tape stripping and cyanoacrylate biopsy (Olesen et al. 2019; Nastiti et al. 2020; Hughes et al. 2021). The skin was tape stripped 15 times using an adhesive surgical tape (3M Transpore, Glasgow, UK). Tape 1 was analysed individually as this would contain unabsorbed materials on the skin surface, whereas tapes 2–5 and 6–15 were analysed together. Following tape stripping, a drop of cyanoacrylate glue was placed on the skin and covered with adhesive tape applied under slight pressure. After 10 min, the cyanoacrylate polymerised and the strip was removed, entrapping the casts of hair follicles. Two successive cyanoacrylate applications were applied to each skin sample and analysed individually. After stripping, the remaining skin was weighed accurately and cut into fine pieces. All skin samples were placed into vials containing 10 ml of methanol and sonicated for 30 min. After sonication (Transonic, Wisbech, UK), the samples were centrifuged for 20 min at 400 rpm (Eppendorf centrifuge 5702, Camberley, UK). The supernatant was collected after centrifugation and the amount of TSN in the remaining skin tissue was determined using HPLC.
Skin hypersensitivity following application of tissue adhesive (2-octyl cyanoacrylate)
Published in Baylor University Medical Center Proceedings, 2021
Raymond P. Shupak, Sid Blackmore, Roderick Y. Kim
Case reports have emerged detailing adverse local and systemic reactions after tissue adhesive usage. Ricci et al documented a case of diffuse cutaneous allergic reaction to Dermabond that required emergency evaluation and treatment.15 Ghaffar et al presented two cases of contact dermatitis that mimicked a knee implant reaction after orthopedic surgery.16 The reactions presented with pruritus and rash several weeks after surgery. Subsequent patch testing showed significant reactivity to the Dermabond solution. Nigro et al recently evaluated a cohort of patients who underwent breast surgery with cyanoacrylate products.17 Twelve patients developed significant dermatitis reactions. Two patients had previous known allergies to cyanoacrylate. The incidence of allergic response to tissue glues was 14% in their study. Those who experienced reactions were confirmed with scratch testing. The authors cautioned against the use of cyanoacrylate due to the high incidence of adverse skin reactions. In another study, Nakagawa utilized Dermabond Advanced as a final occlusive dressing following breast surgery.18 The incidence of contact dermatitis was calculated to be 7% of study participants. The authors concluded that application of Dermabond Advanced should be avoided in patients who have a history cyanoacrylate sensitivity.
Perineal skin tear repair following vaginal birth; skin adhesive versus conventional suture – a randomised controlled trial
Published in Journal of Obstetrics and Gynaecology, 2021
Rima Anggrena Dasrilsyah, Aida Kalok, Beng Kwang Ng, Anizah Ali, Kah Teik Chew, Pei Shan Lim
Some of the advantages using skin adhesive include relatively rapid and painless application. Multiple studies showed that the adhesive application is associated with significant shorter procedure (Bozkurt and Saydam 2008; Singer et al. 2008; Feigenberg et al. 2014). Local anaesthetic is unnecessary and its usage reduces the risk of needle stick injury (Singer et al. 2008). The cyanoacrylate adhesive normally sloughs off after 5–10 days, allowing enough time for the perineal skin to heal whilst providing protective barrier against water and bacteria. This would make skin adhesive an ideal method for first-degree perineal tear repair especially in out of hospital settings such as home birth or midwifery-led centre. However, there is cost implication involved, as tissue adhesive is generally more expensive than suture. In our practice, the cost of Histoacryl is around five times than that of Monosyn, which limits its wide use (RM 61 per tube vs. RM 12 per suture).