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Topical Therapy: Cyanoacrylates and Other Modalities
Published in John P. Papp, Endoscopie Control of Gastrointestinal Hemorrhage, 2019
The various cyanoacrylates differ primarily in the speed with which they polymerize, the degree of tissue irritation they produce, and their biodegradability. For example, methyl-cyanoacrylate (the super glue) polymerizes extremely rapidly, is relatively rapidly biodegradable, and produces an intense tissue irritation. At the other extreme, the isopropyl-cyanoacrylate is slowly biodegradable, produces minimum tissue reaction, and polymerizes more slowly. The trifluoroisopropyl (MBR 4197) is intermediate in these reactions, as is the ethyl-cyanoacrylate. Cyanoacrylate polymerization is triggered by the exposure to moisture; the polymer is resistent to both acid and alkaline pH. There does not appear to be systemic toxicity from the cyanoacrylates.72-100
Nail care and nail cosmetics
Published in Archana Singal, Shekhar Neema, Piyush Kumar, Nail Disorders, 2019
Usually used to elongate nails, these are available at nail salons as ready-to-use plastic plates. They are available in a variety of styles: colored or uncolored, precut or uncut, press-on, pre-glued forms, and in forms requiring glue application. The nails also come in a variety of sizes and shapes to match the patient's natural nail plate. These are glued to the free edge of the nails after a rough filing with adhesives containing methacrylate or ethyl 2-cyanoacrylate. The glued-on tips may then be painted or decorated with nail art and finally coated with acrylic or gel. They can be removed with acetone.
Guidelines for Nanosilver-Based Antibacterial Devices
Published in Huiliang Cao, Silver Nanoparticles for Antibacterial Devices, 2017
Loris Rizzello, Pier Paolo Pompa
In a smart approach, Bayer et al. (2011) developed a direct and effective procedure to functionalise cellulose with different ethyl-cyanoacrylate nanocomposite shells. In particular, the authors were able to surround the single cellulose fibres (of commercially available sheets) with different nanomaterials: MnFe2O4 NPs (to provide magnetic activity to the paper), CdSe/ZnS quantum dots (for light emission), polytetrafluoroethylene particles or submicrometre wax (to render the paper superhydrophobic) and finally Ag NPs to give the substrates antibacterial characteristics (Bayer et al. 2011). The great advantage of this multifold approach is that it uses a cheap post-production method, which maintains the original properties of the sheets completely unperturbed. Figure 15.5 shows the paper sheets modified with several nanomaterials, and some nice applications of this effective multifunctional paper.
A review of recent developments on micro/nanostructured pharmaceutical systems for intravesical therapy of the bladder cancer
Published in Pharmaceutical Development and Technology, 2018
Marcela Brito Oliveira, Mônica Villa Nova, Marcos Luciano Bruschi
Using a factorial design, poly(ethyl-2-cyanoacrylate) (PECA) NP were optimized for encapsulation of epirubicin to be instilled into the bladder. The emulsification-polymerization method was used and the effect of two surfactants, Tween 80 and Poloxamer 188, in concentrations of 0.5 and 2% was compared. It was demonstrated that the NP prepared with Tween 80 were smaller in size (between 96 and 183 nm) than with Poloxamer 188 (220–281 nm). Concerning the IC50 values to NP loaded of epirubicin produced with Tween 80 were 1.19 and 1.20 μg/ml to cancer cells T24 and RT4, respectively. In relation to the NP prepared with Poloxamer 188, the IC50 values were 1.52 and 1.30 μg/ml. This means that the NP developed with Tween 80 were more effective than the particles prepared with Poloxamer 188. Furthermore, it was observed an increased capacity of penetration of NP prepared with Tween 80 into the tissue wall of the pig bladder, suggests a promising system for the treatment of BC (Lu et al. 2011).
Assessment of the Retinal Toxicity and Sealing Strength of Tissue Adhesives
Published in Current Eye Research, 2022
Anna Sharabura, John Chancellor, M. Zia Siddiqui, David Henry, Ahmed B. Sallam
In this in-vitro study, we compared the toxicity of histoacryl, dermabond (2-octyl cyanoacrylate), superglue (ethyl cyanoacrylate), ReSure PEG, and Tisseel fibrin glue on human retinal pigment epithelial (RPE) cells. Additionally, we aimed to assess the relative strengths of these adhesives using porcine retina.
Current status of split-mouth controlled clinical trials comparing cyanoacrylate vs. conventional suture after lower third molar surgeries: a systematic literature review
Published in Acta Odontologica Scandinavica, 2023
Ana Federica Stran-Lo Giudice, Azahara María Ortiz, Luis Sánchez-Labrador, Jorge Cortés-Bretón Brinkmann, Carlos Manuel Cobo-Vázquez, Cristina Meniz-García
All used a split-mouth model, closing the test side with Ethyl-cyanoacrylate [12], Iso-amyl 2-cyanoacrylate [10] or Iso-amyl-cyanoacrylate [11], while Joshi A et al. [10] did not specify the type of cyanoacrylate used. All used 3/0 silk suture on the control side.