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Stimulus-Receptive Conductive Polymers for Tissue Engineering
Published in Naznin Sultana, Sanchita Bandyopadhyay-Ghosh, Chin Fhong Soon, Tissue Engineering Strategies for Organ Regeneration, 2020
Conductive biomimetic materials applied in nerve, cardiac and bone tissue engineering provide a promising alternative to scaffold fabrication. This is due to the importance of electrical stimulation in maintaining bioelectricity hemostasis such as signaling of the nervous system; therefore, electrical stimulation plays an integral role in stimulating cell proliferation and differentiation, especially for fibroblasts, neurons, and osteoblasts. Conductive polymer provides advantages in efficiently delivering electrical signals from an external source to the seeded cells. The desired conductive polymer properties for tissue engineering applications include conductivity, reversible oxidation, redox stability, biocompatibility, non-toxic and hydrophilicity (Guimard et al. 2007).
Brain Stimulation Therapies
Published in Bahman Zohuri, Patrick J. McDaniel, Electrical Brain Stimulation for the Treatment of Neurological Disorders, 2019
Bahman Zohuri, Patrick J. McDaniel
Even before observations of interactions between electricity and brain activity, electrical currents have been used for treating various disorders such as headache and epilepsy. Initial treatments involved using live electric rays and electric catfishes.75 Efforts by a number of pioneers including Walsh, Galvani, Volta, and Aldini lead to the establishment of the field of bioelectricity and subsequently the development of electrotherapy.76 Interest in electrically polarizing brain regions using transcranial weak current stimulation for treating symptoms of psychiatric disorders increased in the 1960s and 1970s with a number of studies showing positive outcomes.77–80 However, the development of drugs which appeared to be more effective in treating psychiatric disorders led to waning interest in transcranial stimulation.
Energy Medicine: Focus on Nonthermal Electromagnetic Therapies
Published in Len Wisneski, The Scientific Basis of Integrative Health, 2017
Len Wisneski, Bernard O. Williams
Bioimpedance measures are obtained when an exogenous electrical potential is applied to a biological organism. Bioelectricity is a broader concept and includes measures of electrical currents associated with bodily function—in other words, endogenous currents. Biological systems have properties that make them different from electrical circuits that are composed of more simple and uniform materials. Electrons are the carriers of current in electrical circuits, while ions transport current in biological materials. Tissues are extremely complex, with heterogeneous materials at multiple spatial scales that have interfacial and frequency-dependent effects that cannot be well modeled by conventional electrical circuit components, such as capacitors and resistors. Many parameters are nonlinear, with values varying depending on intensities, frequencies, and waveforms. For example, at AC frequencies above 1 MHz, ionic flow greatly diminishes because ion movement entails too much inertia to adjust to rapid change in potential current direction. Biological systems are open systems, not as easily isolated as electric circuits. Emotion, perspiration, movement, and respiration can dramatically affect the reliability of electrodermal measurements (Ahn and Martinsen, 2007).
Impact of biomimetic electrical stimulation combined with Femoston on pregnancy rate and endometrium characteristics in infertility patients with thin endometrium: a prospective observational study
Published in Gynecological Endocrinology, 2023
Yilinuer Shabiti, Shaadaiti Wufuer, Remila Tuohuti, Tan Yun, Jing Lu
Bioelectricity is a kind of physicochemical change in life activities, a basic feature of living organisms, and a manifestation of normal physiological activities. Electrophysiology has developed rapidly in different disciplines in recent years. Electrophysiology research can help understand the functional status of the body. It can be used to diagnose diseases (e.g. electrocardiogram), but it can also help intervene for function regulation intervention, and it is possible to use it for disease prevention and treatment clinically. Biomimetic electrical stimulation acts on pelvic floor muscles and nerves through low-frequency currents, promotes lymphatic and blood circulation by stimulating the nerve-muscle-visceral reflex axis, improves endometrial blood flow and tissue nutrition, accelerates the healing of damaged tissue, and promotes endometrial repair [23,24]. A study enrolled 41 patients with a thin endometrium (≤ 7 mm) and undergoing assisted reproductive technology; they received intermittent vaginal electrical stimulation for 20–30 min on treatment days. The results showed that pelvic floor nerve stimulation significantly increased uterine endometrial thickness in patients with a thin endometrium [14]. By stimulating the repeated contraction and relaxation of uterine smooth muscle, the blood supply to the entire endometrial and subendometrial region can be increased, resulting in better nourishment of the endometrial tissues [14].
The realization of robotic neurorehabilitation in clinical: use of computational intelligence and future prospects analysis
Published in Expert Review of Medical Devices, 2020
Jiali Yang, Zhiqi Zhao, Chenzhen Du, Wei Wang, Qin Peng, Juhui Qiu, Guixue Wang
Motion recognition is a technology that utilizes the physical structure and various sensory systems to recognize patterns and intentions of training patients [81,82]. It is achieved by decoding the bioelectricity signal excited when a neuron carrying information on human behavior transmits the signal between tissues/organs [83]. Some scientists believe that this technology presents the best invention key to achieving efficient human-machine coordination in the most comfortable way possible [84–86]. The bigger aim is to combine motion recognition and rehabilitation by building on the success of related work of this technology.
Tailoring synthetic polymeric biomaterials towards nerve tissue engineering: a review
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2019
Hamed Amani, Hanif Kazerooni, Hossein Hassanpoor, Abolfazl Akbarzadeh, Hamidreza Pazoki-Toroudi
The bioelectricity present in the human body contributes to maintaining normal biological functions like wound healing, muscle contraction and signalling of the nerve system [104]. High-rate transportation of electrical charges leads to neural differentiation through the improvement of cell-to-cell or cell-to-substrate interactions. In order to provide optimal conductivity for nerve tissue engineering, coated 3 D PLLA fibrous scaffold with polypyrrole (a conductive polymer) nano-layer through situ surface polymerization [105].