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Wrinkles
Published in Charles Theisler, Adjuvant Medical Care, 2023
Copper-Zinc Malonate: Mahoney et al. evaluated the effects of a bi-metal, 0.1% cop-per-zinc malonate-containing cream on elastin biosynthesis and elastic tissue accumulation in 21 female patients with photo-aged facial skin. After eight weeks of therapy, significant elastic fiber regeneration was seen in the papillary dermis leading to effacement of wrinkles.11
Stimuli-responsive graphene-incorporated multifunctional chitosan for drug delivery applications: a review
Published in Expert Opinion on Drug Delivery, 2019
Sahar Gooneh-Farahani, M. Reza Naimi-Jamal, Seyed Morteza Naghib
CS-incorporated graphene biosensors provide excellent performance due to the large surface area and good electrochemical activity of graphene and good biocompatibility of CS. The presence of amine groups in CS helps integrating the CS to GO and provides a good and stable dispersion of the GO-CS composite. In 2013 for the first time, DNA-based CS-graphene nanocomposites were prepared for rapid and sensitive typhoid detection [247]. As another example in 2014, the Cu-Co nanostructure/rGO/CS modified glassy carbon electrode was prepared for glucose sensing [248]. Nanostructured various metal and metal oxides such as Au, Cu, Cu2O, Co, and Pt were used to modification of electrodes in order to detect glucose level in blood [249–253]. Good selectivity, high stability, and catalytic activity of bimetal such as Au-Ag, Pt-Ni, and Ni-Cu compared to monometal. However, leads which were an ideal component in the electrochemical sensor exhibited better catalytic performance and a higher sensitivity compared to the same monometal [254–258].
Insights into future therapeutics for atopic dermatitis
Published in Expert Opinion on Pharmacotherapy, 2018
Taylor Edwards, Nupur U. Patel, Amy Blake, Samantha Prabakaran, Danielle Reimer, Steven R. Feldman, Lindsay C. Strowd
Crisaborole (also known as AN2728), the first small molecule topical PDE-4 inhibitor FDA approved for the treatment of AD, became available in December 2016 for the treatment of mild to moderate AD in individuals 2 years of age and older. In AD, intractable PDE activity is increased in immune cells, thus inhibiting normal cyclic adenosine monophosphate (Camp) regulation and promoting inflammation [7]. Crisaborole selectively inhibits PDE4 due to the addition of the boron molecule within its chemical structure. The boron atom binds to water in the bimetal center of the active site of PDE4 [8]. This chemical reaction provides a low molecular weight compound (251 Da) that effectively penetrates human skin. By penetrating the skin and inhibiting PDE4, intracellular levels of cAMP are increased and inflammation is minimized. Results from the largest clinical trial to date reported twice-daily (BID) application of crisaborole 2% ointment resulted in total or partial clearance of target lesions in 62% of subjects after 28 days of treatment [9]. The most common adverse effect included application site reaction followed by nasopharyngitis and upper respiratory tract infections. Nausea, vomiting, and headache, which are commonly associated with systemic PDE4 inhibitors, did not occur. In additional phase 3 studies (AD-301: NCT02118766; AD-302: NCT02118792), crisaborole-treated patients achieved investigator’s static global assessment (ISGA) score success of clear/almost clear (2- or greater-grade improvement) more often than the vehicle group (AD-301: 32.8% vs. 25.4%, p = .38; AD-302: 31.4% vs. 18.0%, p < .001) [10]. Adverse events (AEs) in these studies were uncommon and mild to moderate in nature.
Multivariate process dispersion monitoring without subgrouping
Published in Journal of Applied Statistics, 2020
The real dataset that is related to bimetal thermostat is taken from [31]. These types of thermostats hold a bimetallic strip, which is made up of two different metallic strips, that convert the changing of temperature in mechanical displacement due to the difference in thermal expansion. The strip, obtained by combining brass and steel metals, is analyzed in a quality laboratory by testing 5 quality characteristics, namely, the deflection, curvature, resistivity, and hardness in low and high expansion sides. The quality control department takes both Phase-I and Phase-II datasets from the manufacturing process, each dataset consists of 28 samples, containing 5 measurements. As the underlying process parameter 3 for the Phase-I dataset. It is observed that none of the multivariate charts have issued an out-of-control signal, thus stating that the manufacturing process is in-control for the Phase-I dataset. On similar lines, these multivariate charts are displayed in Figure 4 for the Phase-II dataset. The multivariate charts now issue out-of-control signals to indicate that the manufacturing process has gone out-of-control because of an upward shift in the in-control covariance matrix. The first out-of-control signals initiated by the CCUSUM, EWMA, ACCUSUM and AEWMA charts are at the 11th, 10th, 10th and 9th samples, respectively. The AEWMA chart signals earlier than the other charts considered here.