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Maternal genome and pregnancy outcomes
Published in Moshe Hod, Vincenzo Berghella, Mary E. D'Alton, Gian Carlo Di Renzo, Eduard Gratacós, Vassilios Fanos, New Technologies and Perinatal Medicine, 2019
Nagendra K. Monangi, Ge Zhang, Mikko Hallman, Kari Teramo, Bo Jacobsson, Louis J. Muglia
The first WES analysis followed by pathway analysis from families highly affected by spontaneous preterm birth found the complement and coagulation cascade pathway was enriched in harboring rare variants (23). One of these loci, complement receptor 1 (CR1), was subsequently found to harbor a more common exome variant that contributed to preterm birth risk in nuclear families in the Finnish population. Genome-wide screening identified IGF1 as a candidate gene variant associated with preterm birth (24). Subsequent study involved sequencing of haplotype blocks and selected exomes with the aim to define pathways and candidate genes. Another WES study of Finnish families identified multiple variants enriched in estrogen and glucocorticoid receptor (GR) pathways, and replication Danish sister pairs both with PTB showed HSPA1L, a nuclear hormone receptor chaperone, rare variants in several families (25).
The Usefulness of Antisperm Antibodies Testing
Published in Nicolás Garrido, Rocio Rivera, A Practical Guide to Sperm Analysis, 2017
Mónica Hebe Vazquez-Levin, Clara Isabel Marín-Briggiler, Carolina Veaute, Rosa Molina, Gustavo Luis Verón
Both in men and in women, Chlamydia trachomatis, Ureaplasma urealyticum, and Mycoplasma hominis are among the most studied microorganisms related with the presence of ASA.35,37,40–43 Cross-reactivity between sperm and bacteria antigens has been proposed as an alternative mechanism for the induction of ASA 37,41. In fact, heat shock protein 70 (HSP70) from C. trachomatis and urease complex component (UreG) from U. urealyticum share epitopes with the sperm proteins HSPD1, HSPA2, and HSPA1L,44 and nuclear autoantigenic sperm protein,40 respectively. In addition, it was observed that patients with human papillomavirus (HPV) infection have a high incidence of ASA, and these antibodies mainly bind to spermatozoa containing viral proteins, suggesting that the presence of HPV components on the sperm surface could be an antigenic stimulus for ASA formation.45 However, controversial results from different studies call into question the association of ASA with infection.46,47
Mapping the human sperm proteome – novel insights into reproductive research
Published in Expert Review of Proteomics, 2023
Mika Alexia Miyazaki, Raquel Lozano Guilharducci, Paula Intasqui, Ricardo Pimenta Bertolla
Meanwhile, research involving HSP70 isoforms provides a good overview of the AZS sperm proteomics [50,61]. Interestingly, Grassi and coworkers [50] did not find differences in the HSP70 pattern expression using MRM analysis and any correlation between HSP70 isoforms and percentage of motile sperm and progressive motility. Nevertheless, Ayaz and collaborators [45] identified higher expression of HSPA2 in patients with high ROS. In addition to that, HSPA2, HSPA1L, and HSPA9 (HSP70 isoforms) would be good biomarkers to study sperm motility, because in NMZ sperm, by blocking these isoforms, there was a decreasing rate of motile progressive sperm and rectilinear velocity [45,61,62].
Liver transcriptome analysis reveals biological pathways and transcription factors in response to high ammonia exposure
Published in Inhalation Toxicology, 2022
Daojie Li, Shuangzhao Chen, Chun Liu, Baoxing Wei, Xiaoping Li
With adjusted p-value <0.05 and basemean >100 thresholds, 556 genes showed significant differential expression between the control group and ammonia group by using the DESeq2 package. Of which, 351 were up-regulated and 205 were down-regulated in the ammonia group compared with that of the control group (Figure 2). Some DEGs were highly expressed, such as AHSG, CES1, CFH, SCD, and ACTG1. And some DEGs had higher log2(fold change), such as CD207, FOS, HSPA1L, KLHDC8A, and CCN1.