China
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Order Picornavirales
Published in Paul Pumpens, Peter Pushko, Philippe Le Mercier, Virus-Like Particles, 2022
Paul Pumpens, Peter Pushko, Philippe Le Mercier
The preliminary x-ray data to 3.6 Å resolution of swine vesicular disease virus (SVDV), strain JX/78, a member of the Enterovirus B species, which shared some antigenic properties with Coxsackievirus B5 (CVB5) and could be a recently evolved genetic sublineage of this important human pathogen, were published first by Lin W et al. (2002). Then, three different crystal forms of SVDV, isolate SPA/2/’93, were obtained by Jimenez-Clavero et al. (2003). Fry et al. (2003) presented the 3.0-Å crystal structure of highly virulent strain UK/27/72 of SVDV, which revealed the expected similarity in core structure to those of other picornaviruses, showing most similarity to the closest available structure to CBV5, that of CBV3. Remarkably, the authors mapped the aa substitutions that might have occurred during the supposed adaptation of SVDV to a new host.
Peptide vaccines
Published in F. Y. Liew, Vaccination Strategies of Tropical Diseases, 2017
The disease is caused by a picornavirus, 30 nm in diameter and similar in structure to the viruses causing poliomyelitis, the common cold, and swine vesicular disease. Immunity to the disease is correlated with the level of virus-neutralizing antibody in the serum of vaccinated animals. The virus consists of an RNA genome of mol wt c 2.6 × 106 surrounded by 60 copies of each of three surface proteins VP1-VPS, mol wt c 24 × 103, and one internal protein VP4, mol wt c 10 × 103.
Evaluation of a commercial enzyme-linked immunosorbent assay (ELISA) for detecting antibodies against Toxoplasma gondii from naturally and experimentally infected pigs
Published in Infectious Diseases, 2019
Giusi Macaluso, Santina Di Bella, Giuseppa Purpari, Elisabetta Giudice, Francesco Mira, Francesca Gucciardi, Anna Maria Fausta Marino, Carmelo Russo, Maria Angeles Gómez-Morales, Annalisa Guercio
One hundred and twenty seven swine serum samples were analyzed. One hundred and fifteen sera were derived from previous sampling carried out during the Italian control plans for Swine Vesicular Disease (SVD), Classical Swine Fever (CSF), Aujeszky's Disease. Twelve sera were kindly provided by the European Union Reference Laboratory for Parasites (EURLP) as reference materials; two samples originated from pig sera that tested negative for anti-Toxoplasma IgG and 10 sera originated from pigs inoculated with RH strain of T. gondii. All serum samples from experimentally infected animals were collected on day 70 (final day of experiment). From experimentally infected pig sera, three sera derived from animals which had been vaccinated with 1.2 × 105 tachizoites of the S48 strain of T. gondii and subsequently infected with 103 oocysts of the M4 strain; four sera were from animals infected with 103 oocysts of the M4 strain and three serum samples were from animals infected with 103 tissue cysts of the M4 strain. Details of the experimental infections can be found elsewhere [27]. All the serum samples were tested at the EURLP by an commercial ELISA (anti-Toxoplasma IgG, ID Screen® Toxoplasmosis Indirect Multi-species, from IDvet) and by two collaborative studies organized by the EURLP in 2015 and 2016, resulting in accordance with their assigned positivity.