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Microsurgical Autologous Lymph-Vessel Grafting
Published in Waldemar L. Olszewski, Lymph Stasis: Pathophysiology, Diagnosis and Treatment, 2019
The patients get low molecular dextran for 1 week. Antibiotics are given perioperatively to prevent early erysipelas. Elastic stockings are prescribed to be worn for about half a year. Thereafter according to the behavior of the extremity, they can be discarded.
Head and neck infections
Published in S. Musheer Hussain, Paul White, Kim W Ah-See, Patrick Spielmann, Mary-Louise Montague, ENT Head & Neck Emergencies, 2018
Muhammad Shakeel, AE Louise McMurran
Erysipelas and cellulitis are the most common skin and soft tissue infections requiring in-hospital treatment. Erysipelas is a superficial skin infection that does not involve the subcutaneous tissue. It has a typically raised, well demarcated and localised rash compared to cellulitis. Cellulitis involves both the dermis and the subcutaneous tissue. Clinically, it may be difficult to differentiate between these two conditions, and lately these are considered manifestations of the same condition. These are commonly caused by Streptococci and Staphylococci and are treated with antibiotics, but community-associated methicillin resistant Staphylococcus aureus is a growing problem. In diabetics and patients with suppressed immunity, a deep-seated infection should always be kept in the differential diagnosis of a superficial skin infection.
Skin and subcutaneous tissue
Published in Professor Sir Norman Williams, Professor P. Ronan O’Connell, Professor Andrew W. McCaskie, Bailey & Love's Short Practice of Surgery, 2018
Professor Sir Norman Williams, Professor P. Ronan O’Connell, Professor Andrew W. McCaskie
This is a bacterial infection of the skin and subcutaneous tissue that is more generalised than erysipelas. It is usually associated with broken skin or pre-existing ulceration. It is characterised by an expanding area of erythematous, oedem- atous tissue that is painful, in association with fever, malaise and leucocytosis. Erythema tracking along lymphatics may be visible (lymphangitis) (Figure40.8). The commonest causative organism is Streptococcus. Blood and skin cultures for sensitivity should be taken before prompt administration of broad spectrum, intravenous antibiotics and elevation of the affected extremity.
Time to positivity of blood cultures in bloodstream infections with Streptococcus dysgalactiae and association with outcome
Published in Infectious Diseases, 2023
Anna Bläckberg, Katrina Lundberg, Stina Svedevall, Bo Nilson, Magnus Rasmussen
Clinical features recorded for every episode of S. dysgalactiae bacteraemia included demographics such as age, gender, place of acquisition (community, hospital or healthcare- related), Charlson comorbidity index (CCI) [15] and antibiotic treatment. Healthcare-related infection was defined as a blood culture obtained in the initial 48 h of hospitalisation if the patient had had healthcare within 30 days prior to the episode as an outpatient or if the patient had been discharged from the hospital within 90 days prior to the current episode [16]. The modified Duke criteria were applied to diagnose IE [17]. Source of infection was recognised by fulfilment of at least two out of three different criteria which comprised; signs or symptoms of an infection; microbiological evidence of S. dysgalactiae at the site of infection; imaging consistent with focal infection. Since erysipelas is a clinical diagnosis, typical features were regarded as sufficient to verify the condition.
Epidemiology, aetiology and treatment of skin and soft tissue infections: final report of a prospective multicentre national registry
Published in Journal of Chemotherapy, 2022
Silvano Esposito, Pasquale Pagliano, Giuseppe De Simone, Angelo Pan, Paola Brambilla, Gianni Gattuso, Claudio Mastroianni, Blertha Kertusha, Carlo Contini, Lorenzo Massoli, Daniela Francisci, Giulia Priante, Marco Libanore, Roberto Bicocchi, Guglielmo Borgia, Alberto Enrico Maraolo, Pierluigi Brugnaro, Sandro Panese, Alessandra Calabresi, Giovanni Amendola, Francesca Savalli, Consuelo Geraci, Andrea Tedesco, Sara Fossati, Anna Carretta, Teresa Santantonio, Giovanni Cenderello, Maria Paola Crisalli, Elisabetta Schiaroli, Pierangelo Rovere, Giulia Masini, Roberto Ferretto, Antonio Cascio, Claudia Colomba, Claudia Gioè, Mario Tumbarello, Angela Raffaella Losito, Giuseppe Foti, Tullio Prestileo, Calogero Buscemi, Chiara Iaria, Carmelo Iacobello, Sofia Sonia, Giulio Starnini, Anna Ialungo, Mauro Sapienza
A total of 478 diagnoses of SSTIs were posed in our registry, the most common being cellulitis, representing 26.7% of overall SSTIs, followed by erysipelas (16.7%), surgical site infections (10.5%), DFI (9.0%), infected trophic ulcer (8.4%) and abscess (7.7%). Comparing our data with those reported elsewhere, the percentages of cellulitis and abscesses appear to be lower, but it should be noted that in many studies abscesses and cellulitis are considered in the same category (thus the group of cellulitis/abscess easily reaches higher percentages, from 50% to 63%) [7, 19]. Furthermore, while in our analysis 10% of the overall SSTIs were diagnosed as erysipelas, other authors considered erysipelas in the same category of cellulitis/abscess with no further distinctions. Thus, adding the percentages of cellulitis, abscess and erysipelas diagnosed in our registry we obtain a percentage close to 51% that is quite similar to previously published data. In addition, the rates of DFI, surgical wound and infected trophic ulcer are much closer to data published by Garau et al. [18].
Quantile-specific heritability of serum growth factor concentrations
Published in Growth Factors, 2021
Erysipelas is an acute β-hemolytic streptococcus bacterial infection of the upper dermis and superficial lymphatic vessels of primarily the legs and face (Henningham et al. 2015). Superoxide dismutase 2 (SOD2) is a mitochondrial antioxidant that prevents harmful effects of free radicals. Emene et al. (2017) reported that relative to recovery, CC homozygotes of the SOD2 rs11575993 (T2734C) polymorphism had significantly elevated HGF concentrations during the acute phase of erysipelas infections that were substantially reduced by treatment (Figure 4(D)). From the perspective of quantile expressivity, the substantially elevated HGF concentrations during the acute phase vis-à-vis recovery (322 versus 113 pg/ml) accentuated the HGF differences between SOD2 genotypes.