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Bacterial and parasitic infections
Published in Aimilios Lallas, Enzo Errichetti, Dimitrios Ioannides, Dermoscopy in General Dermatology, 2018
Ignacio Gómez Martín, Balachandra Suryakant Ankad, Enzo Errichetti, Aimilios Lallas, Dimitrios Ioannides, Pedro Zaballos
Human demodicosis is a skin disease of the pilosebaceous units associated with human Demodex mites (Demodex folliculorum and Demodex brevis), which are widely known ectoparasitic mites mainly localized on the face.31 Such a condition can be classified into a primary form and a secondary form (associated with systemic or local immunosuppression).
A LIFE ON THE SKIN
Published in Rob Norman, The Woman Who Lost Her Skin, 2004
Nothing amongst all the unsuspected secrets of one's skin is more astonishing than the thought that the roots of one's eyelashes are colonized by mites. Few people can confront with equanimity the idea that worm-like creatures which have been likened to eight-legged crocodiles squirm out their diminutive lives in warm oily lairs in our hair follicles. Demodex folliculorum usually involves the face and Demodex brevis commonly infests the chest and back. Rosacea, a multiphasic disease, is associated with flushing, erythrosis, papulopustular rosacea and phymas; each phase is likely to have its own treatment. Demodex is an important factor in the inflammatory reaction. Helicobacter pylori has also been associated with rosacea. In immunocompromised hosts Demodex may overpopulate and bring on dermatitis. The related follicle mite in dogs (it appears identical but is unable to live on man) is responsible for mange. Demodex mites are implicated in demdectic alopecia or "human mange." Pull down thy vanity, it is not man Made courage, or made order, or made grace, Pull down thy vanity, I say pull down. Learn of the green world what can be thy place In scaled invention or true artistry, Pull down thy vanity [...] The green casque has outdone your elegance. (Ezra Pound, Canto 81, 1948) What else of our normal flora? The skin is sterile at birth but only remains so briefly. Examining the umbilicus for Staphylococcus aureus shows 25% colonization in the first day of life with a steady increase from then on. We have two types of normal skin flora - transient and resident. Resident flora are capable of
Non‐pharmaceutical treatment options for meibomian gland dysfunction
Published in Clinical and Experimental Optometry, 2020
Lid hygiene is also thought to be important because of the association of Demodex mites with MGD.2018 Long‐term practice of lid hygiene is necessary in individuals with Demodex infestation as it is a chronic condition that requires chronic therapy. Demodex folliculorum and Demodex brevis are thought to be the most common ectoparasites in humans. In the eye, D. folliculorum is found preferentially in the lash follicles and D. brevis in lash sebaceous glands.1981 There is a strong association between ocular demodicosis and ocular surface inflammatory conditions such as blepharitis, chalazia, and keratitis as well as MGD.2019 The pathogenesis of Demodex infestation has remained unclear;2000 however, this is in part because demodicosis has a high age‐dependent prevalence and is present frequently in asymptomatic individuals.2010
Ivermectin 1% (CD5024) for the treatment of rosacea
Published in Expert Opinion on Pharmacotherapy, 2018
Dev R. Sahni, Steven R. Feldman, Sarah L. Taylor
Ivermectin 1% cream is a topical compound used for the treatment of papulopustular rosacea. The pathophysiology of papulopustular rosacea involves neurovascular dysregulation and immune system alteration. An underlying common microbial factor associated with rosacea is the Demodex mite [12]. There are two types of Demodex mites which are natural inhabitants of human skin and are found in or near the pilosebaceous units: Demodex folliculorum and Demodex brevis [13]. This mite is found in increased numbers in patients with rosacea [12]. The novel therapeutic mechanism of ivermectin in targeting Demodex mites appears to make it a particularly effective treatment option.
Anti-Demodex Effect of Commercial Eyelid Hygiene Products
Published in Seminars in Ophthalmology, 2021
Demodex folliculorum and Demodex brevis are the most common ectoparasites that invade the pilosebaceous unit of the skin, which can cause clinical conditions.1D. folliculorum is longer (0.3–0.4 mm) and causes infestation especially in the roots of eyelashes, whereas D. brevis is shorter (0.2–0.3 mm) and causes infestation in the sebaceous glands.2D. folliculorum is particularly associated with anterior blepharitis, whereas D. brevis is more with posterior blepharitis.3