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Use of Dermatologics during Pregnancy
Published in “Bert” Bertis Britt Little, Drugs and Pregnancy, 2022
Podophyllin is a topical agent used to treat condyloma acuminata. A solution of 20 percent podophyllin solution in tincture of benzoin is used to treat condyloma. Use of podophyllin during pregnancy is associated with significant edema, skin irritation, and discomfort. The frequency of birth defects was not increased in frequency among 14 infants whose mothers used podophyllin during the first trimester (Heinonen et al., 1977), but this sample was too small to interpret. Several anecdotal reports of maternal and fetal toxicity include a case of fetal demise in a mother who experienced systemic toxicity following the topical application of podophyllin (Gorthey and Krebs, 1954) and others that reported similar adverse effects (Chamberlain et al., 1972; Slater et al., 1978).
Carcinoma of the Vagina and Vulva
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2020
Sadaf Ghaem-Maghami, Kostas Lathouras
This slowly growing neoplasm is rarely seen on the vulva. Both macroscopically and histologically, it resembles condyloma acuminata, and the diagnosis can be difficult. Generous biopsies are required to provide sufficient material for the pathologist. The treatment is surgery, usually a radical vulvectomy but very occasionally wide local excision. The place of lymphadenectomy is debatable, as lymph node metastases are uncommon.
Penile Cancer
Published in Manit Arya, Taimur T. Shah, Jas S. Kalsi, Herman S. Fernando, Iqbal S. Shergill, Asif Muneer, Hashim U. Ahmed, MCQs for the FRCS(Urol) and Postgraduate Urology Examinations, 2020
Hussain M. Alnajjar, Asif Muneer
Condyloma acuminatum is a predominantly a sexually transmitted infection caused by human papillomavirus (HPV) and spread through oral, anal and genital sexual contact and is therefore a benign condition. All of the other genital dermatoses are associated with penile SCC. Lichen sclerosus and Bowenoid papulosis are sporadically associated with penile SCC, whereas, Paget’s disease and Buschke-Löwenstein are precancerous lesions and up to 30% transform into invasive SCC.
CO2 laser treatment for pearly penile papules – personal experience
Published in Journal of Cosmetic and Laser Therapy, 2019
Anna Deda, Aleksandra Lipka-Trawińska, Sławomir Wilczyński, Barbara Błońska-Fajfrowska
The lesions, prior to their removal, were diagnosed, including differential diagnosis for condyloma acuminata and molluscum contagiosum (11). PPP do not contain human papilloma virus and there is no relationship between the occurrence of condyloma and PPP (21). Molluscum contagiosum can be distinguished clinically from PPP based on umbilicated papules that are larger in size (3). In the dermoscopic image, PPP resemble grape-shaped structures where each lesion contains characteristic blood vessels in the shape of dots or commas (19,22). However, it should be noted that this vascular pattern is not characteristic and can also be observed in the case of condyloma (22,23). Nevertheless, PPP have a more homogeneous structure in the dermoscopic image due to the absence of exfoliation (23).
British Journal of Biomedical Science in 2018: what have we learned?
Published in British Journal of Biomedical Science, 2019
Condyloma acuminatum (CA) is a common, viral, sexually transmitted disease worldwide, and is linked to human papillomavirus (HPV, as is cervical cancer). Zhong et al. [52] developed a loop-mediated isothermal amplification (LAMP) method to detect HPV in 294 cervical smears, of which 152 were positive for one of the HPV genotypes (defined by PCR using specific primers), whilst 142 were HPV-negative, and compared it with the Luminex method. Tissues from 40 patients with a pathological diagnosis of CA were paraffin-embedded and analysed by LAMP and Luminex. The kappa value between the two methods varied between 0.68 and 0.98 for different HPV genotypes. Of the 142 HPV-negative samples determined by the Luminex assay, HPV-6 was detected in eight and HPV-11 in one by LAMP. Amongst the 40 CA samples, the results of LAMP and Luminex were in agreement in 38 (95%). These data indicate that the LAMP assay is superior to the Luminex method in terms of sensitivity and specificity, and is therefore a useful, quick and accurate method for the clinical diagnosis of HPV subtypes.
Proteomic and bioinformatic analysis of condyloma acuminata: mild hyperthermia treatment reveals compromised HPV infectivity of keratinocytes via regulation of metabolism, differentiation and anti-viral responses
Published in International Journal of Hyperthermia, 2019
Yu-Zhe Sun, Jia-Feng Li, Zhen-Dong Wei, Hang-Hang Jiang, Yu-Xiao Hong, Song Zheng, Rui-Qun Qi, Xing-Hua Gao
Condyloma acuminatum (CA) is a common, sexually-transmitted disease observed worldwide that develops from human papillomavirus (HPV) infection. Among all HPV subtypes, CA is primarily the result of either a HPV 6/11 (low-risk types) or HPV 16/18 (high-risk types) infection [1]. CA patients are typically treated with physical therapies such as CO2 laser ablation and cryotherapy, however, recurrence is oftentimes observed due to failures in eliminating invisible HPV-infected loci [2]. Although 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) is effective in treating latent HPV infection and reducing recurrence of CA [2], the relatively high medical expenses and pain associated with this therapy limits its application, especially in patients with massive lesions. Therefore, there exists a clear need for the development of more effective and economic therapeutic methods.