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Thermography by Specialty
Published in James Stewart Campbell, M. Nathaniel Mead, Human Medical Thermography, 2023
James Stewart Campbell, M. Nathaniel Mead
Although technically a myopathy, myositis is a condition causing inflammation in muscles. Infection, trauma (acute or chronic), autoimmune conditions, and drug effects may cause myositis (Table 11.1). Weakness, local swelling, and pain are the most common symptoms, generally occurring in central muscles in younger individuals, and in peripheral muscles in older subjects. The onset of myositis may herald an occult malignancy. Myositis involves local invasion of mast cells releasing histamine and macrophages generating NO.
Complications of Equine Anesthesia
Published in Michele Barletta, Jane Quandt, Rachel Reed, Equine Anesthesia and Pain Management, 2023
Signs of myositis in the recovery stall include: Prolonged recovery.Hard, swollen, and painful muscles.Excited or “rough” recovery.Myoglobinuria.
Inflammatory Myopathy
Published in Maher Kurdi, Neuromuscular Pathology Made Easy, 2021
The obstacle with muscle biopsy is that it is not only used as a confirmatory test, but it is sometimes difficult to discern what type of myositis is seen in the biopsy. Overlapping clinical phenotypes and autoantibodies among IMs entities make the diagnosis difficult to establish. Indeed, the clinician must combine all findings together to reach a final conclusion.
A single-institution review of lacrimal gland biopsies between 1962 and 2017
Published in Orbit, 2023
Catherine J. Choi, Ann Q. Tran, Apostolos G. Anagnostopoulos, Henry W. Zhou, David T. Tse, Sander R. Dubovy
If the lacrimal gland lesion is large enough to exert mass effect on the globe inducing non-axial proptosis in the inferomedial direction, limitation in extraocular motility can be seen. In cases of inflammatory conditions, some degree of myositis in the adjacent muscles can play a role. Seventy-one such cases were noted, quantified as 25% restriction to frozen globe, and summarized in Table 4. Diagnoses spanning all categories were noted. Given that ocular dysmotility would typically be expected in moderately advanced cases, it is interesting to note that a few non-diagnostic specimens were nonetheless present (lymphocytic infiltrate, non-diagnostic for lymphoma, fibrovascular tissue). Of the cases non-diagnostic for lymphoma, pathology reports for two of the specimens stated that features suggestive of, but not diagnostic of lymphoma were present, highlighting the issues of diagnostic yield of biopsies.
Growth differentiation factor-15 as an emerging biomarker for identifying myositis
Published in Expert Review of Clinical Immunology, 2022
A heterogeneous group of rare muscle diseases are due to autoimmune processes that target the skeletal muscle tissue, and are termed myositis. Division of myositis patients in subgroups relevant to disease management are continuously refined and scrutinized [1–7], and myositis may associate with risk of malignancy [8]. Different patient subgroups present with distinct clinical and myopathological characteristics, and differing disease prognosis and therapeutic response. Diagnostic criteria include disease phenotyping, clinical testing, and assaying muscle damage patterns with electromyography, magnetic resonance imaging and histopathologic evaluation in a muscle biopsy. To aid subtyping of patients, an expanding variety of myositis-specific and myositis-associated autoantibodies are being described. The major subgroups recognized today are immune-mediated necrotizing myopathy (IMNM), dermatomyositis (DM), sporadic inclusion body myositis (IBM), polymyositis (PM), and myositis as part of the anti-synthetase syndrome (ASS).
Docetaxel-induced acute myositis: a case report with review of literature
Published in Journal of Chemotherapy, 2021
Sariya Wongsaengsak, Miguel Quirch, Somedeb Ball, Anita Sultan, Nusrat Jahan, Mohamed Elmassry, Shabnam Rehman
Myositis associated with paclitaxel has been reported in a Kaposi sarcoma patient in 2006,16 and in a stage 3 ovarian cancer patient in 2016.17 To our best knowledge, acute myositis related to docetaxel still remains a very rare complication, and there are only a small handful of reported cases (Table 1).18–22 Most of these patients developed myositis after 30-90 days of docetaxel exposure. They had symmetric involvement of proximal muscles of the lower extremities. Interestingly, 4 out of 6 patients had diabetes mellitus as their comorbidities, which could be a predisposing factor since they may have baseline peripheral neuropathy. Only one of these patients had a muscle biopsy done, which showed nonspecific acute inflammatory myopathy.19 The treatment of myositis in this group of patients involved a course of corticosteroids and pain control. All but one patient had full recovery to baseline muscle strength after 1 − 4 weeks of treatment.