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The Host Response to Grafts and Transplantation Immunology
Published in Julius P. Kreier, Infection, Resistance, and Immunity, 2022
These promoter region polymorphisms, because they polarize responses toward cell-mediated or antibody-mediated responses, may influence allograft rejection. Thus, an individual who has a genetically encoded tendency to make higher levels of interleukin-10 and lower levels of interferon-y has a tendency to polarize toward antibody mediated responses. Studies have shown that transplant receipts with the genetic profile for high interferon-γ/low interleukin-10 production have significantly more frequent and more severe acute rejection episodes. In contrast, individuals with the genetic profile for low interferon-γ/high interleukin-10 production have significantly longer graft survival with fewer acute rejection episodes. Some transplant surgeons are now beginning to use cytokine promoter region allele typing to tailor immunosuppressive drug therapy for a specific recipient. Cytokine promoter region alleles also may influence chronic rejection. Individuals who have a high TGF-β production phenotype have more severe chronic rejection in a recent study. As mentioned earlier, TGF-β is a potent smooth muscle mitogen and probably accounts for some of the smooth muscle cell proliferation in the intima of vessels in the graft that occurs during chronic rejection. TGF-β is also involved in the fibrosis seen in the lesions.
Regenerative Medicine in Pain Management
Published in Sahar Swidan, Matthew Bennett, Advanced Therapeutics in Pain Medicine, 2020
Sharon McQuillan, Rafael Gonzalez
Interleukin-10 (IL-10) is known to be a powerful anti-inflammatory cytokine affecting inflammation and immunoregulation. The role of IL-10 remains elusive in pain management, with conflicting study results. A study by Li et al. demonstrated that the effects of MSCs were reversed by TGF-β and IL-10 antibody neutralization.29 These data suggest that IL-10 plays a critical role in reducing pain and inflammation.
Endotoxin Tolerance
Published in Helmut Brade, Steven M. Opal, Stefanie N. Vogel, David C. Morrison, Endotoxin in Health and Disease, 2020
F. Ulrich Schade, Regina Flach, Sascha Flohé, Matthias Majetschak, Ernst Kreuzfelder, Emilio Domínguez-Fernández, Jochen Börgermann, Martin Reuter, Udo Obertacke
Interleukin-10 possesses considerable anti-inflammatory properties. It is of interest here that in vitro desensitization of monomac 6 cells resulted in increased production of IL-10 (47). IL-10 has been implicated in the process of in vitro desensitization since antibodies against IL-10 prevented the downregulation of TNF synthesis in cultured human monocytes by preincubation with LPS (46). On the other hand, the same authors reported that LPS desensitization of human monocytes resulted in impaired IL-10 formation of the cells when restimulated with LPS (46).
Nutritional Status of Allogeneic Hematopoietic Stem Cell Transplant Recipients and Post-transplant Outcomes
Published in Nutrition and Cancer, 2023
Stephanie Szovati, Caroline F. Morrison, Sarah C. Couch
Interleukin-10 is an anti-inflammatory cytokine that suppresses inflammatory processes in mature immune cells (32). Higher spontaneous interleukin-10 production in transplant patients is associated with fewer transplant related complications (33,34). Holler et al. found that patients with increased interleukin-10 at the time of admission had uneventful transplant courses and suggested a protective role of interleukin-10 (35). In the current study there was a trend for higher interleukin-10 levels post-transplant compared to pre-transplant, which suggests that on average, participants were moving into the phase of inflammation resolution and recovery. Additionally, the association between greater dietary quality of participants pre-transplant and higher IL-10 suggests the importance of optimizing patients’ nutritional status before transplant to promote synthesis of anti-inflammatory cytokines, such as IL-10, that aid in recovery.
Brain magnetic resonance imaging without contrast significantly increased serum levels of IL-6, but not IL-10, IL-17A and TGF-β
Published in Brain Injury, 2021
Faezeh-sadat Khorram, Ali Mehdipour, Amir Moghadam-Ahmadi, Habib Farahmand, Azadeh Askari, Seyed Mohsen Moosavi, Ahmad Shabanizadeh, Masoumeh Parsi, Mohammad Kazemi Arababadi
The cytokines are the main messengers of the immune cells and modulate immune cell functions, including cell migration, activation and suppression. Interleukin-10 (IL-10) is a powerful anti-inflammatory cytokine and regulates immune cell functions (12). The cytokine not only participates in the immune response homeostasis, potentially regulates auto-reactive immune cells (13). In contrast to IL-10, IL-17A, the main cytokine produced by Th17 lineage, significantly participates in the induction of pro-inflammatory diseases and auto-immunities (14). It has been demonstrated that transforming growth factor-beta (TGF-β) and IL-6 are the main inducers of the Th17 lineage (15). Therefore, the environmental factors that increase expression of TGF-β, IL-6 and IL-17A cytokines and decrease IL-10 may be considered as the risk factors for induction of pro-inflammatory-based diseases.
Interleukin-10 may have diagnostic value in identifying mild traumatic brain injury
Published in Brain Injury, 2020
Anti–inflammatory interleukin-10 has recently been a major issue for research (8). The presence of interleukin-10 in the brain increases in the pathologic conditions of the brain, such as brain trauma and stroke, in order to maintain the survival of neural and glial cells and weaken the inflammatory responses (7). However, their application to mTBI is uncertain (5). In this regard, limited studies examined the diagnostic value of this interleukin in detecting brain lesions following mTBI. Recently, Lagerstedt et al. (2018) measured various inflammatory biomarkers (including 92 inflammatory biomarkers) in patients with mTBI and compared those values with brain CT scan results. The results showed that interleukin-10 might be a useful diagnostic tool to differentiate patients with positive and negative CT scan findings for brain lesions. However, performing more confirmatory investigations was suggested by authors (9).