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Histiocytic and Dendritic Cell Neoplasms
Published in Dongyou Liu, Tumors and Cancers, 2017
Classified along with mature B-cell neoplasms, mature T and NK neoplasms, Hodgkin lymphoma, and post-transplant lymphoproliferative disorders (PTLD) under the mature lymphoid, histiocytic, and dendritic neoplasms category, histiocytic and dendritic cell neoplasms consist of (i) histiocytic sarcoma (HS), (ii) Langerhans cell histiocytosis (LCH), (iii) Langerhans cell sarcoma (LCS), (iv) indeterminate dendritic cell tumor (IDCT), (v) interdigitating dendritic cell sarcoma (IDCS), (vi) follicular dendritic cell sarcoma (FDCS), (vii) disseminated juvenile xanthogranuloma (DJX), and (viii) Erdheim–Chester disease (ECD) (Table 27.1) [1].
A case of spindle cell dominant histiocytic sarcoma showing a complete remission after first-line chemotherapy with doxorubicin and ifosfamide
Published in Journal of Chemotherapy, 2020
Yusuke Nakamura, Akihiro Takemasa, Yoshitomo Kushima, Sayo Soda, Naoya Ikeda, Ryo Arai, Kazuyuki Chibana, Yoshimasa Nakazato, Tomoyuki Yokose, Yasuo Shimizu, Seiji Niho
HS is an extremely rare hematopoietic neoplasm that is often misdiagnosed as non-Hodgkin lymphoma.2 Diagnosis requires recognition of the atypical histiocytic morphology of tumor cells and expression of histiocyte-associated markers, followed by exclusion of the many differential diagnoses using extensive immunohistochemical markers.2 The differential diagnosis of HS includes malignant lymphomas, LCS, interdigitating dendritic cell sarcoma (IDCS), and follicular dendritic cell sarcoma (FDCS).1–3 In our patient, the histiocyte markers CD 68 and CD163 were both positive. LCS was excluded because CD1a was negative, CD4 positivity did not support IDCS, and FDCS was excluded as CD21 negative.5,12 In addition, T cell and B cell lymphoma were excluded as cells negative for CD3 and CD20. Considering all the above, we made a final diagnosis of HS in this patient.
Successful Treatment of Interdigitating Dendritic Cell Sarcoma Presenting as Multiple Parotid Tumors
Published in Acta Oto-Laryngologica Case Reports, 2019
Yasuyuki Kajimoto, Naoki Otsuki, Masanori Teshima, Yukiko Morinaga, Tomoo Itoh, Ken-Ichi Nibu
Interdigitating dendritic cell sarcoma (IDCS) is an exceedingly rare neoplasm derived from antigen-presenting cells of the immune system. It mostly occurs in the cervical and axillary lymph nodes. To our knowledge, to date, only three patients with IDCS arising from the parotid gland has been reported. Most patients were treated with surgery with or without radiotherapy and/or chemotherapy, and prognosis varied.