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Women and Coronary Heart Disease (CHD)
Published in Mark C Houston, The Truth About Heart Disease, 2023
Heart disease risk factors for women that are more common than in men include the following:Diabetes mellitus. Women with diabetes are more likely to have CHD than men with diabetes mellitus.Mental stress, anxiety, and depression.Smoking.Menopause. Low levels of estrogen after menopause pose a significant risk of developing CHD in the small coronary arteries.Pregnancy complications. High blood pressure or diabetes during pregnancy can increase the mother's long-term risk of both hypertension and CHD.Family history of early heart disease. This may be a greater risk factor in women than in men.Inflammatory diseases. Rheumatoid arthritis, systemic lupus, and other autoimmune diseases will increase CHD.
Gut Microbiota—Specific Food Design
Published in Megh R. Goyal, Preeti Birwal, Santosh K. Mishra, Phytochemicals and Medicinal Plants in Food Design, 2022
Aparna V. Sudhakaran, Himanshi Solanki
Postbiotics are the nonviable bacterial products or metabolites produced by the probiotic strains having biological effects on the host. It is an effective alternative method to increase the potential and functionality of each probiotic strain. Moreover, it avoids the risk associated with handling live bacterial cells. It can be developed as a novel therapy for many inflammatory diseases [72].
Food Interactions, Sirtuins, Genes, Homeostasis, and General Discussion
Published in Chuong Pham-Huy, Bruno Pham Huy, Food and Lifestyle in Health and Disease, 2022
Chuong Pham-Huy, Bruno Pham Huy
Inflammation includes acute inflammation and chronic inflammation. Acute inflammatory diseases are acute bronchitis, sore throat from a flu, tonsillitis, acute appendicitis, and so on. Chronic inflammatory diseases include asthma, rhinitis, allergy or hypersensitivity, muscular pain, osteoarthritis, arthritis, psoriasis, gout, inflammatory bowel diseases (Crohn’s disease, ulcerative colitis), chronic rheumatoid arthritis, systemic lupus erythematosus, and more. Rheumatoid arthritis and lupus are auto-immune diseases. Chronic inflammation is another important factor that may cause or assist in the pathogenesis of many chronic diseases including CVD, cancers, and Type 2 diabetes (6).
Sarcoid-like Uveitis with or without Tubulointerstitial Nephritis during COVID-19
Published in Ocular Immunology and Inflammation, 2023
Hilal Eser-Ozturk, Tugba Izci Duran, Ozlem Aydog, Yuksel Sullu
Cases presenting with various ocular clinical manifestations have been reported since COVID-19 first appeared in December 2019.2,3,7–9 Differential diagnosis of the other infectious and inflammatory diseases during diagnostic procedures of these patients very important. Eye involvement associated with COVID-19 is mostly in the form of conjunctivitis, but cases of uveitis have also been reported. Cases of uveitis that occur during the COVID-19 pandemic can be somewhat confusing. In a 5-year period, the number of sarcoid-like panuveitis in the pediatric age group was five in our clinic.16 However, this year, we saw seven patients with similar characteristics in an 8-month period. In addition, four of the patients had acute TIN and were evaluated as (TINU). We think that this may be related to COVID-19, since there has been an increase in the number of patients presenting with this clinic recently in our outpatient clinic and that COVID-19 can cause a sarcoid-like reaction.17–19
Recent trends in platelet membrane-cloaked nanoparticles for application of inflammatory diseases
Published in Drug Delivery, 2022
Zhengyu Fang, Jie Fang, Chunxiao Gao, Rui Gao, Peihong Lin, Wenying Yu
Inflammation is an immune response, a defense mechanism of the body, and the basis of a variety of physiological and pathological processes in the body (Karin & Clevers, 2016). Inflammation is closely related to many diseases, including rheumatoid arthritis (RA), atherosclerosis (AS), ischemic heart disease, cancer and bacterial infectious diseases. Given that inflammation plays a fundamental role in the development of these diseases (Jin et al., 2018), how to alleviate inflammation may be one of the important therapeutic options for these inflammatory diseases. To date, many anti-inflammatory drugs have entered clinical trials, and their therapeutic effects on various types of acute and chronic inflammation have been verified. However, although high doses of anti-inflammatory drugs (such as hormones) can actively suppress autoimmune reactions, extensive systemic immunosuppression may cause severe adverse reactions and sequelae (such as femoral head necrosis) and profoundly affect quality of life after recovery. Hence, a targeting drug delivery system that modulates local inflammatory immune responses to potentially reduce drug dosage and toxic and side effects is of great significance.
Rituximab Attenuated Lipopolysaccharide-Induced Oxidative Cytotoxicity, Apoptosis, and Inflammation in the Human Retina Cells via Modulating the TRPM2 Signaling Pathways
Published in Ocular Immunology and Inflammation, 2022
Hatice Daldal, Mustafa Nazıroğlu
Vision-threatening and common inflammatory ocular diseases such as uveitis, macular degeneration, retinopathies are serious problems worldwide.1,2 Recently, intravenous immunoglobulin, interferon, and tumor necrosis factor-alpha (TNF-α) antagonist treatments have been used in severe ocular inflammation that is refractory to corticosteroids and other immunosuppressive agents.3 However, the etiology and full treatment of the inflammatory diseases have not been clarified yet. Hence, the discovery of effective treatment is an important and urgent issue in the treatment of inflammatory diseases. In recent years, adult retina pigment epithelial-19 (ARPE-19) cells have been used in studies, because this layer plays a significant role in the pathogenesis of many inflammatory diseases.4–6 The major inflammatory cytokines such as TNF-α and interleukin-1beta (IL-1β) are produced by ARPE-19 cells in response to different stimulations.7,8