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Standards for Personnel Performing Hemapheresis Therapies
Published in James L. MacPherson, Duke O. Kasprisin, Therapeutic Hemapheresis, 2019
The orientee should, at the end of the first week, be able to: Take an accurate medical history from a donor before donation.Perform donor hematocrit, and assess whether or not it is within acceptable range; perform total protein analysis and do same.Identify donor testing to be done at the time of donation.Accurately prepare donor chart and assemble laboratory tubes to be used for testing.Set up Haemonetics Model 30 for plateletpheresis with assistance.Run a donor for plateletpheresis with assistance.Have a general overview of the objectives and total functioning of the unit.
Organisation of the medical services in Iraq and Afghanistan
Published in Ian Greaves, Military Medicine in Iraq and Afghanistan, 2018
The Danish three-month deployment, following hard on the heels of Operation Panther’s Claw, turned out to be the most intense period of activity to date at Bastion. Records were broken for the number of surgical procedures, CT scans performed per day, laboratory investigations processed, units of blood transfused and activations of the platelet apheresis and emergency blood donation panels.103
Blood Groups, Blood Components and Alternatives to Transfusion
Published in John C Watkinson, Raymond W Clarke, Louise Jayne Clark, Adam J Donne, R James A England, Hisham M Mehanna, Gerald William McGarry, Sean Carrie, Basic Sciences Endocrine Surgery Rhinology, 2018
Samah Alimam, Kate Pendry, Michael F. Murphy
Platelets are central to haemostasis. Platelet transfusions may be needed in patients with thrombocytopenia or platelet function disorders. Platelet concentrates are prepared either by centrifuging whole blood or from a single donor via plateletpheresis using a cell separator. Platelets are stored at 22 °C in an incubator that is constantly agitated for optimal platelet storage. Platelets have a shelf life of 7 days following the recent introduction of bacterial screening in the UK.
Assays for phenotypic and functional characterization of cryopreserved platelets
Published in Platelets, 2019
Platelet transfusions are essential for the treatment of patients with acute bleeding and for prevention of bleeding in severe thrombocytopenia [1]. Platelet concentrates for transfusion can be prepared by pooling buffy coats from whole blood donations or by automated collection from a single donor by plateletpheresis. Platelet concentrates are conventionally stored at room temperature (20–24°C), with constant agitation. This limits their shelf-life to 5–7 days, due to the risk of bacterial proliferation at room temperature [2], and gradual deterioration of platelet quality and function, known as the platelet storage lesion [3]. The limited shelf-life poses many supply chain and logistic issues, particularly for remote or rural regions, where platelet usage is intermittent and maintaining a supply of platelets without unacceptable wastage can be challenging.
Contemporary management of patients with BCR-ABL1-negative myeloproliferative neoplasms during pregnancy
Published in Expert Review of Hematology, 2018
Martin Griesshammer, Parvis Sadjadian, Kai Wille
Plateletpheresis is an effective maneuver to reduce the platelet counts in the short term; however, long-term control can only be achieved by repeated procedures. There are a few reports of plateletpheresis in pregnant women with ET [75,76,77]. The platelet lowering effect of plateletpheresis is mostly transient and there is no proof that lowering the platelet count by plateletpheresis reduces MPN-related complications in pregnancy. In our opinion, plateletpheresis has a limited role in the management of ET and pregnancy and there may be an indication in symptomatic patients with a platelet count in excess of 2000 × 109/l.
Does plateletpheresis induce a hypercoagulable state? A global assessment of donor’s hemostatic system by ROTEM
Published in Platelets, 2019
O. Meltem Akay, Fatih Taştekin, Ertuğrul Çolak
In conclusion, our study has demonstrated that plateletpheresis dose not induce a hypercoagulable state in healthy donors. As far as we know, this is the first study to investigate the effects of plateletpheresis on donor’s coagulation system by utilizing a newer and more powerful technique, ROTEM. Since ROTEM demonstrates hemostasis as a whole dynamic process and gives more information on interaction between different components of the hemostatic system, we suggest that plateletpheresis is unlikely to produce any significant thrombotic risk to be of concern in regard to safety of donors undergoing plateletpheresis.