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Interleukin-1
Published in Jason Kelley, Cytokines of the Lung, 2022
Timothy R. Aksamit, Gary W. Hunninghake
Interleukin-1 is one of the hemopoietic growth factors. It acts with other growth factors (like IL-3) to trigger release of GM-CSF, G-CSF, M-CSF, and IL-6 (Vogel et al., 1987; Zucali et al., 1986; Bagby et al., 1986; Fibbe et al., 1986; Stanley et al., 1986; Lee et al., 1987). In this capacity, IL-1 can exert a protective effect on bone marrow elements following radiation- or chemotherapy-induced neutropenia (Neta et al., 1986; Moore and Warren, 1987). Interestingly, the importance of endogenous IL-1 in protecting bone marrow from radiation was demonstrated recently in a study in which an IL-1 receptor antibody was shown to reduce radioprotection and outcome (Neta et al., 1990). Neutrophils have high-affinity IL-1 receptors (Rhyne et al., 1988). Interleukin-1 will increase thromboxane synthesis by these cells (Dinarello and Savage, 1989), cause degranulation (Smith et al., 1985), and stimulate a neutrophil O2-dependent metabolism (Klempner et al., 1979). The, in vivo, chemotactic activity of IL-1 for neutrophils appears to be related to IL-1–induced synthesis of IL-8 (Dinarello, 1989).
Genetic Manipulation of Human Marrow: Gene Transfer Using Retroviruses
Published in Adrian P. Gee, BONE MARROW PROCESSING and PURGING, 2020
Philip Hughes, R. Keith Humphries
An increasing number of hemopoietic growth factors are now known to play an important role in the control of proliferation and differentiation of progenitors and stem cells. These effects made us wonder whether growth factors could be used to facilitate gene transfer using retroviruses. We originally studied the combination of supraoptimal concentrations of GM-CSF plus IL-1β, compared to standard bone marrow growth conditions.26 The growth factors were present during the infection period, which was a 24-h cocultivation with cells producing a neor-containing virus.
Summation of Basic Endocrine Data
Published in George H. Gass, Harold M. Kaplan, Handbook of Endocrinology, 2020
There is a growing literature on the role of extracellular factors in the proliferation and differentiation of hemopoietic cells. The mechanisms involve hemopoietic growth factors, cytokines, and oncogenes.3
Allergen challenge-induced changes in bone-marrow responses to leukotriene D4, nonsteroidal anti-inflammatory drugs and cytokines
Published in Immunopharmacology and Immunotoxicology, 2020
Daniela Masid-de-Brito, Bruno M. Vieira, Carina C. de Souza, Francisco Silva, Maria I. C. Gaspar-Elsas, Pedro Xavier-Elsas
Here we expand and refine the characterization of the effects of allergen challenge on bone-marrow eosinopoiesis, originally defined by eosinophilia in vivo, accompanied by increased responses to IL-5 and IL-3 ex vivo [1], to include challenge-induced changes in the responses to a variety of secondary (i. e., IL-5-dependent) stimuli, which share a requirement for CysLT1R signaling. After the initial observation of the loss of stimulatory effects of NSAID on cultured murine bone-marrow in the presence of the hemopoietic growth factors [2], and the demonstration that such stimulatory effects of NSAID [6], like those of eotaxin and IL-13 [9], were mediated by CysLT1R, we show here that they are replaced by a significant suppressive effect on eosinophil production, in the presence of any of the agents tested, relative to cytokine-only controls. By comparison of exogenous LTD4 (5-LO-independent) to the other stimuli, it is clear that challenge affects responses to CysLT1R signaling, rather than 5-LO activity.