China
Africa
Explore chapters and articles related to this topic
Peripheral Blood and Bone Marrow
Published in Harold R. Schumacher, William A. Rock, Sanford A. Stass, Handbook of Hematologic Pathology, 2019
Fermina Maria Mazzella, Gerardo Perrotta
It is very important to evaluate the size of RBCs on the peripheral smear, since size may be the first clue to the cause of an anemia. The erythrocytes are macrocytic (large), normocytic (normal), or microcytic (small) when compared to the nucleus of the mature lymphocyte. Variation in size (anisocytosis) is estimated and recorded on a 0 to 4-plus scale or simply as present or increased.
Haematology
Published in Stephan Strobel, Lewis Spitz, Stephen D. Marks, Great Ormond Street Handbook of Paediatrics, 2019
HS is typically characterised by pallor, jaundice, splenomegaly, reticulocytosis and polymorph erythrocytes on a peripheral blood smear. Severe anaemia can be experienced by 5–10% of patients. There is a classic blood smear appearance with numerous small, dense spherocytes and bizarre erythrocyte morphology with anisocytosis (Fig. 11.63C).
Reproductive System and Mammary Gland
Published in Pritam S. Sahota, James A. Popp, Jerry F. Hardisty, Chirukandath Gopinath, Page R. Bouchard, Toxicologic Pathology, 2018
Justin D. Vidal, Charles E. Wood, Karyn Colman, Katharine M. Whitney, Dianne M. Creasy
In laboratory animals, mammary epithelial hyperplasias are generally divided into lobuloalveolar (acinar) and ductal forms. This division is based on the different biological responses between these compartments and perhaps also on morphologic classification of human breast cancers, which are predominantly ductal in origin. Lobuloalveolar hyperplasias can indicate general enlargement of the lobular unit (relative to surrounding tissue) or increased number of cells or cell layers within a subset of acini in a lobule. Ductal hyperplasias (DHs) arise in the epithelium of inter- or intralobular ducts and are characterized by three or more layers of epithelium (including myoepithelium) which may form solid, papillary, or micropapillary structures extending into the lumen. When features such as anisocytosis, anisokaryosis, piling or crowding of epithelium, or loss of cellular polarity are present, the hyperplasia may be classified as atypical.
Focused ultrasound ablation of a large canine oral tumor achieves efficient tumor remission: a case report
Published in International Journal of Hyperthermia, 2021
Ashish Ranjan, Deepan Kishore, Harshini Ashar, Tina Neel, Akansha Singh, Sunil More
Before the treatment, we obtained owner consent to the terms of the study, including a follow-up postmortem analysis and release from institutional/personal (researcher) liability. All animal related procedures were approved by the Oklahoma State University Animal Care and Use Committee. The canine patient was a 3 year and 8-month-old pit bull mix with an identifiable tumor of 4.3 × 3.8 × 3.8 cm (width × length × height) on the left maxilla. The initial examination of the patient revealed hematological and biochemical parameters in normal ranges. A pretreatment biopsy revealed an un-encapsulated multinodular mass with low cellularity, composed of oval to spindle-shaped neoplastic cells arranged in whorls or bundles supported by a loose fibrovascular stroma (Figure 1). The neoplastic cells had variably distinct cell borders with moderate amounts of eosinophilic fibrillar cytoplasm and single nuclei with finely stippled chromatin and indistinct nucleoli. Anisocytosis and anisokaryosis were mild. The neoplastic cells showed diffuse, moderate to strong cytoplasmic immunoreactivity toward GFAP, laminin, and S100 proteins—findings indicative of an aggressive neurilemmoma (schwannoma) tumor.
Unexplained haemolytic anaemia associated with pregnancy combined with severe gestational thrombocytopenia
Published in Journal of Obstetrics and Gynaecology, 2019
Jing Liu, Lu Ji, Guang Song, Tao Meng
A 29-year-old G1P0 woman was admitted to our hospital in the 34th week of gestation with severe anaemia and thrombocytopenia. Anaemia and thrombocytopenia appeared at 12 weeks of gestation and declined as gestation progressed (Table 1). The patient had no symptoms or tendency of haemorrhage. Neither she, nor any other family member, had a previous history of anaemia or thrombocytopenia. Physical examination showed a gravid woman with no discomfort. Her temperature was 36.7 °C, respirations were 18 per min and unlaboured; pulse was 91 bpm, and blood pressure was 130/70 mmHg. Investigations showed the following: haemoglobin (61 g/l), haematocrit (0.183), mean corpuscular volume (111.6 fl), mean corpuscular haemoglobin (37.2 pg), mean corpuscular haemoglobin concentration (333 g/l), platelets (28 × 109/l) and reticulocytes (25%). Biochemical analysis showed a normal total serum bilirubin and alanine aminotransferase. Urine and stool analysis were normal. Ferratin was increased at 171.10 µg/l, while serum vitamin B12 and serum folate were normal. The blood film showed a marked anisocytosis with macro- and poikilocytosi, while indirect and direct Coombs test results were negative. Bone marrow smears showed a proliferation of normoblasts without maturation abnormalities. Antiphospholipid antibody and rheumatic antibody were all negative.