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Gastric Cancer
Published in Pat Price, Karol Sikora, Treatment of Cancer, 2020
Mark A. Baxter, Russell D. Petty
Perhaps the area of greatest controversy in the surgical management of patients with potentially curative gastric cancer is the extent of surgical resection required to achieve this goal. Most authorities would now agree that total gastrectomy is not always required if sufficient tumor clearance is possible without removal of the whole stomach. Similarly, routine removal of adjacent organs is only indicated where there is direct tumor extension into these, and even then, the increased surgical morbidity must be balanced against the limited benefits in patients with such extensive disease. The upper gastrointestinal tract (GI) surgical community is, however, divided in the attitude towards the extent of lymphadenectomy required in curative resections of the stomach. Meticulous mapping of lymph-node involvement for tumors in different anatomical locations within the stomach led to the concept of systematic lymph-node dissection in Japan.
Gastrointestinal cancer
Published in Peter Hoskin, Peter Ostler, Clinical Oncology, 2020
Laparoscopic surgery is an alternative to open gastrectomy. There are fewer cases of ileus and postoperative chest infections after laparoscopic surgery but it might result in fewer lymph nodes being removed. Long-term outcomes from ongoing trials are therefore awaited.
Jejunal Transposition after Total or Partial Gastrectomy — an Experimental Model in the Rat
Published in Waldemar L. Olszewski, CRC Handbook of Microsurgery, 2019
A. Santini, E. Morsiani, M. Baccarini
Dissatisfaction with established techniques of reconstruction after partial or total gastrectomy led to the development of several studies and researches. In fact there have been failures as a result of the anatomical and physiological changes caused by surgery. Many operations have been devised, but often there are many undesirable side effects, not only due to the resection of the stomach, but also to loss of the sphincteric mechanism of the pylorus.
Becoming and being a parent with an inherited predisposition to diffuse gastric cancer: A qualitative study of young adults with a CDH1 pathogenic variant
Published in Journal of Psychosocial Oncology, 2023
Erin Tutty, Rowan Forbes Shepherd, Cass Hoskins, Rebecca Purvis, Mary Shanahan, Alex Boussioutas, Laura E. Forrest
Hereditary Diffuse Gastric Cancer (HDGC) is an inherited cancer predisposition syndrome caused by germline pathogenic variants (PVs) in the CDH1 gene. Individuals with a CDH1 PV have significantly increased (42% for males, 33% for females) lifetime risks of diffuse gastric cancer and may choose to manage their cancer risk by undergoing prophylactic total gastrectomy or participating in regular gastroscopic surveillance until malignant cells are detected and gastrectomy is recommended.1 Whilst total gastrectomy effectively eliminates one’s risk of diffuse gastric cancer, it is associated with myriad long-term health complications.2–6 Malnutrition, persistent weight loss, iron deficient anemia, osteoporosis, and “dumping” syndrome (i.e., when food moves to quickly through the stomach causing diarrhea, nausea, tiredness, or lightheadedness after a meal) from gastrectomy can negatively impact quality of life and mental health while individuals adjust to post-surgery eating patterns and bodily changes.2–6
Predictive value of nomogram based on Kyoto classification of gastritis to diagnosis of gastric cancer
Published in Scandinavian Journal of Gastroenterology, 2022
Jiejun Lin, Huang Su, Qingjie Zhou, Jie Pan, Leying Zhou
Cases of esophagogastroduodenoscopy at Wenzhou Central Hospital, Zhejiang University (China) from January 2019 to November 2019 were retrospectively collected. The inclusion criteria were as follows: referral for esophagogastroduodenoscopy, patients aged ≥ 18 years, with serum pepsinogen assay and confirmed histopathological diagnosis through endoscopic approach or surgery. The exclusion criteria were the history of surgical gastrectomy of gastric neoplasm. Of 16412 esophagogastroduodenoscopy cases from January 2019 to November 2019 at the Endoscopy Center of the Department of Gastroenterology, 13777 cases were excluded due to the lack of solid histopathological diagnosis or serum PGs and 2639 cases were enrolled in our study. The study protocol was approved by our ethical review board of Wenzhou Central Hospital, number L2021-03-001x.
Long-Term Outcome in Gastric Cancer Patients with Different Body Composition Score Assessed via Computed Tomography
Published in Journal of Investigative Surgery, 2021
Da Zhou, Ying Zhang, Xuejin Gao, Jianbo Yang, Guoli Li, Xinying Wang
According to statistics, in 2018, stomach cancer is the fifth most common malignancy in the world, after lung cancer, breast cancer, prostate cancer and colorectal cancer [1]. In China, the disease burden of gastric cancer is still relatively heavy, because 410,400 new cases of gastric cancer were diagnosed and 293,800 people died of gastric cancer in 2014 [2]. Currently, the main treatment for gastric cancer is surgery combined with chemotherapy, but the risk of serious complications and mortality after radical gastrectomy is high [3]. Clinical indicators such as age, comorbidities, and tumor stage had been considered to be prognostic factors of prognostic importance [4]. In recent years, more and more studies have shown that malnutrition is also an adverse factor affecting the prognosis and treatment effect of cancer patients. In addition, cancer patients, especially those with gastric cancer, had a higher risk of malnutrition, with about 19% of hospitalized patients receiving radical gastrectomy suffered from malnutrition [5–7]. Despite the constantly improved nutritional support technology and the concept of enhanced recovery after surgery [8,9], the incidence of malnutrition in gastric cancer patients is still high and patients with malnutrition have a poor prognosis and quality of life after surgery [10–12]. Hence, we need to better and faster identify malnourished patients in gastric cancer.