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Cronkhite−Canada Syndrome
Published in Dongyou Liu, Handbook of Tumor Syndromes, 2020
Cronkhite−Canada syndrome (CCS) is a rare sporadic/non-inherited disorder with an adult-age onset. Clinically, CCS is characterized by epithelial disturbances in both the gastrointestinal tract and epidermis, ranging from gastrointestinal hamartomas, juvenile type gastrointestinal polyps (often associated with diarrhea), colorectal serrated adenomas, ectodermal dysplasia, skin hyperpigmentation (darkening skin on the hands, arms, palms, soles, neck, and face), alopecia (hair loss), onychodystrophy (nail atrophy), peripheral edema (excess fluid accumulation in arms and legs), to malabsorption. This is accompanied by increased malignant transformation (with gastrointestinal cancer and multiple myeloma or Kahler's disease occurring in up to 15% of cases) and unprovoked thromboembolism, leading to a high mortality of 55% [1,2].
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Published in Anton Sebastian, A Dictionary of the History of Medicine, 2018
Cronkhite–Canada Syndrome Characterized by gastrointestinal polyposis and ectodermal changes including alopecia and nail and skin changes. Described by an American physician, Leonard W. Cronkhite of Massachusetts General Hospital, and an American radiologist, W.J. Canada, from St Luke’s Hospital, Massachusetts, in 1955.
Test Paper 2
Published in Teck Yew Chin, Susan Cheng Shelmerdine, Akash Ganguly, Chinedum Anosike, Get Through, 2017
Teck Yew Chin, Susan Cheng Shelmerdine, Akash Ganguly, Chinedum Anosike
Cronkhite–Canada syndrome occurs in older patients with an average age of 60 with no familial predisposition. The histologic appearance of the GI polyps resembles that of juvenile polyps, and they are characteristically distributed throughout the stomach. They are commonly small, sessile and characterised by cystic dilatation of the glands and inflammation of the lamina propria. Patients commonly present with abdominal pain, protein-losing diarrhoea, anorexia and weight loss. Dystrophic nail changes and alopecia usually appear after the onset of GI symptoms.
Cronkhite-Canada syndrome: a retrospective analysis of four cases at a single medical center
Published in Scandinavian Journal of Gastroenterology, 2022
Xing Yu, Chengdang Wang, Mi Wang, Yinchen Wu, Linlin Zhang, Qinyu Yang, Long Chen
Cronkhite-Canada syndrome (CCS) is an extremely rare disease with a prevalence rate of 3.7 (male: 4.0; female: 3.5) per 1,000,000 population [1] and is characterized by multiple gastrointestinal polyps and ectodermal abnormalities [2]. Since the disease was first reported by Cronkhite and Canada in 1955 [3], more than 500 cases have been documented worldwide, of which 75% were from Japan [4]. Analysis of CCS data from Japan and China showed that the average age of onset was 63.5 and 57.39 years, respectively, and the condition tended to be more common in males than females [5,6]. At present, the diagnosis of CCS mainly depends on typical symptoms, including gastrointestinal disorders, ectodermal dysplasia, and endoscopic observations [7]. Usually, patients have at least one manifestation of alopecia, nail dystrophy, and skin pigmentation. Gastrointestinal symptoms, such as diarrhea, abdominal pain, and hypogeusia have also been observed [4]. Diffuse multiple polyps of various shapes can be distributed throughout the digestive tract, most commonly in the stomach and colon [5].
Cronkhite–Canada syndrome causing pouch outlet obstruction 5 years after roux-en-y gastric bypass
Published in Acta Chirurgica Belgica, 2019
Ben Gys, Joren Mertens, Martin Ruppert, Guy Hubens
Cronkhite–Canada syndrome is a rare noncongenital gastrointestinal polyposis syndrome characterized by epithelial disturbances in the gastrointestinal tract and epidermis. Symptoms consist of diarrhea, weight loss, abdominal pain and dermatological problems like cutaneous hyperpigmentation, dystrophic changes of finger- and toenails and alopecia. The syndrome typically presents itself in the 5th decade and has a slight male predominance (3:2 ratio) [3].