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Published in Anton Sebastian, A Dictionary of the History of Medicine, 2018
Skene Gland Paraurethral glands of the female described in 1880 by Alexander Johnston Chalmers Skene (1838–1900), an American gynecologist of Scottish origin. He was professor of gynecology at the Long Island College Hospital in NewYork.
Anatomy of the vulva
Published in Miranda A. Farage, Howard I. Maibach, The Vulva, 2017
Aikaterini Deliveliotou, George Creatsas
Skene’s or paraurethral glands are homologous to the prostate in the male. They are branched, tubular glands, adjacent to the distal urethra. Usually, Skene’s ducts run parallel to the long axis of the urethra for approximately 1 cm before opening into the distal urethra. Sometimes they open into the area just outside the urethral orifice. The duct of the Skene’s gland presents an opening on its posterior surface. Skene’s glands are the largest of the paraurethral glands; however, many smaller glands empty into the urethra.
The Skene’s gland cyst that was not: an atypical presentation of a leiomyoma
Published in Journal of Obstetrics and Gynaecology, 2020
Erich T. Wyckoff Facog, Girard M. Cua, Leora Lieberman, Ashwin S. Akki
Skene’s glands exist in females as analogous structures to the male prostate. Although their exact purpose remains debated, the current consensus is that these structures both lubricate the urethral opening and prevent ascending urinary tract infections (Foster et al. 2016; Laura et al. 2017). Histologically, these structures are positioned within a bed of fibromuscular stromal tissue and are lined by pseudostratified columnar epithelium (Shah et al. 2012). The most common pathology associated with Skene’s glands is Skene’s gland cysts. In this report, we present an unusual case of a mass which was thought to be a Skene’s gland cyst, but on excision had pathological findings consistent with a Leiomyoma.
Skene’s Gland Cyst – Case Report of a 2-Year-Old Girl
Published in Fetal and Pediatric Pathology, 2023
Patrícia Sousa, Susana Correia-de-Oliveira, Marcos Guimarães, Ângela Dias, João Moreira-Pinto
In a follow-up consultation five months later, the mass remained unaltered. A total excision with primary closure was performed without intraoperative or postoperative complications. The histopathologic analysis showed a glandular structure lined with transitional cell epithelium, consistent with Skene’s gland cyst (Fig. 2A and B). Follow-up evaluation revealed complete resolution, with no morbidity or recurrence to date.
Xenografts on nude mouse diaphragm of human DU145 prostate carcinoma cells: mesothelium removal by outgrowths and angiogenesis
Published in Ultrastructural Pathology, 2022
Dr Jacques Gilloteaux, James M Jamison, Jack L Summers, Henryk S Taper
Worldwide, prostate cancers are currently estimated about 7.3% of all new cancer cases and, from recent public health references, almost 1.5 million aged men result of more than 375,000 deaths in 2021.1-3 This cancer can be associated with rare breast cancer.4 Cancer of the female prostate or Skene’s gland is rare but cannot be ignored; it is also marked by an elevation of the prostate-specific antigen (PSA).5,6 Aromatase disruptors such as Kepone (USA), Merex (UK), Képone, or Curlone (Europe), used in tropical and other farming zones, as insecticides, have been shown to be co-carcinogens for prostate anomalies.7–9 Since prostate is an androgen-dependent tubulo-alveolar glandular organ, whose epithelial cells possess androgen receptors,10–13 the organ maintenance and growth are dependent of a constant supply of androgens in the form of dihydrotestosterone in the adult, leading to benign prostatic hyperplasia (BPH) and, eventually, to cancers in aging.10–21 These metastatic growths are typically accompanied by progress of angiogenesis.22–28 Prostate tumor invasions cause cancer death mainly by metastases in distant vital organs, such as bone marrow, spleen, lung, liver, and the central nervous system (spinal cord and brain) reached through the lymphatic and blood circulations.24–31 Thus, androgen influence’s ablation has been the first line of treatment for patients with androgen-dependent carcinoma because it induces the cessation of cell proliferation.15,17,19–21,32,33 This was initiated in rat model34 through the activation of programmed cell death (apoptosis) through activation of a Ca2+, Mg2+-dependent endonuclease which is identical or closely related to deoxyribonuclease I (DNase I).35–39 However, in advanced carcinomas, if 70–80% of men initially respond well to androgen withdrawal, most of the non-responding patients relapse because of the development of hormone-resistant and hormone-independent cells.40–43 Likewise, with most recent immunotherapy treatment, prostate cancers have revealed only 18% success.44–46