China
Africa
Explore chapters and articles related to this topic
Sjögren's Disease
Published in Jason Liebowitz, Philip Seo, David Hellmann, Michael Zeide, Clinical Innovation in Rheumatology, 2023
Several studies have assessed the role of noncoding RNA (ncRNAs) in SjD, specifically micro-RNAs (miRNAs); miRNAs are highly conserved small single-stranded RNA molecules that can interfere with translation by binding to mRNA (86). In one study, there was a correlation between miRNA expression and SjD laboratory parameters, including different serum IgG and anti-SSB/La antibody frequencies (103). In another, downregulated miRNA 200–5P expression in SjD labial glands preceded lymphoma development, suggesting the potential use of this miRNA as a biomarker of lymphoma risk (104).
Perioral Region
Published in Ali Pirayesh, Dario Bertossi, Izolda Heydenrych, Aesthetic Facial Anatomy Essentials for Injections, 2020
Krishan Mohan Kapoor, Philippe Kestemont, Jay Galvez, André Braz, John J. Martin, Dario Bertossi
The inferior labial artery (ILA) arises from the facial artery before or near the angle of the mouth, passing superomedially beneath the DAO, and may run in the mental crease. The ILA or its branch may penetrate the orbicularis oris to run between the muscle layer and the mucosa. It supplies the inferior labial glands, mucosa, muscle layer, and skin in this area. It anastomoses with its contralateral artery and with the mental artery, a branch of the inferior alveolar artery, emerging from the mental foramen.
Anatomy and Embryology of the Mouth and Dentition
Published in John C Watkinson, Raymond W Clarke, Terry M Jones, Vinidh Paleri, Nicholas White, Tim Woolford, Head & Neck Surgery Plastic Surgery, 2018
The minor salivary glands of the mouth include the buccal, labial, lingual, palatal and palatoglossal glands. The buccal and labial glands contain both mucous and serous elements. The palatal glands are mucous glands. They are located in both the soft and hard palate. The anterior and posterior lingual glands are mainly mucous. The anterior glands are embedded within muscle near the ventral surface of the tongue and open by means of four or five ducts near the lingual frenum. The posterior glands are located in the root of the tongue. Around the circumvallate papillae are serous glands (of Von Ebner). The palatoglossal glands are mucous glands and are located around the pharyngeal isthmus.
Stem cell therapy for salivary gland regeneration after radiation injury
Published in Expert Opinion on Biological Therapy, 2023
Akshaya Upadhyay, Simon D Tran
Adipose-derived mesenchymal stem cells (ADSCs) were found to be successful and safe in phase 1/2 clinical studies [21]. Improvement in saliva flow by 30–50% was observed over 1–4 months after treatment with autologous or allogeneic ADSCs [20,21,23]. Over the years, our lab has moved from conventional MSCs (bone marrow MSC or ADSC) to less invasive approaches like labial gland-derived MSCs (LMSCs) and their products, with similar therapeutic effects in murine models [24]. Furthermore, in SGs, a wide variety of stem cells have been identified, but their discussion is beyond the scope of this work; we invite the readers to consult the work by Rocchi et al. [25]. We recommend adhering to the isolation of pure MSCs for therapeutic purposes even if the cells are sparse in adult tissues (Figure 2A) since their significant in vitro expansion is possible due to the high proliferation potential of these cells. It will reduce the heterogeneity across different laboratories and facilities, which remains a challenge with stem cell therapies. Moreover, it follows the FDA concept of homologous use, using the same source of MSC cells as the target organ (http://www.ipscell.com/2015/01/stemhumanexperiment).
Sjögren’s syndrome concurrent with organizing pneumonia with secondary systemic capillary leak syndrome: a case report
Published in Scandinavian Journal of Rheumatology, 2021
In December 2019, a 50-year-old, 52 kg woman presented to hospital with fever, cough, and shortness of breath for 2 weeks. She has been in good health and has a long-term dry mouth. Upon admission, computed tomography (CT) of the chest showed multiple lung inflammations and bilateral pleural thickening (Figure 1A), and echocardiography demonstrated pericardial effusion. Laboratory findings showed hypoxaemia, hypoalbuminaemia, elevated immunoglobulin G (IgG), and strong positivity for both anti-Sjögren’s syndrome antigen A (anti-SSA) and anti-Ro52 (Table 1). Labial gland biopsy suggested multifocal lymphocytic infiltration between the acinars and dilated ducts (> 50/4 mm2). Serological tests were negative for influenza virus, parainfluenza virus, respiratory syncytial virus, adenovirus, Epstein–Barr virus, cytomegalovirus, human immunodeficiency virus, legionella, mycoplasma, chlamydia, and tuberculosis bacteria. The (1,3)-β-D-glucan and galactomannan tests (G and GM tests) were also negative. Moreover, multiple bacterial cultures in blood and pharyngeal swabs were all negative..
Acute Syphilitic Posterior Placoid Chorioretinitis Misdiagnosed as Systemic Lupus Erythematosus Associated Uveitis
Published in Ocular Immunology and Inflammation, 2020
Chunli Chen, Shuya Wang, Xiaorong Li
Labial salivary gland biopsy (Figure 8) that showed lobule atrophy of labial gland and multiple focus lymphocytic infiltration was grade 3 with Focus score (FS) = 1 according to Chisholm classification5, which was supportive of Sjogren’s syndrome (SS). The laboratory examination showed that human leucocyte antigen-27 (HLA-27) was negative, phospholipid syndrome antibody was negative, CD3 + T cell subset was 85.47%, perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) was positive, and cytoplasmic antibodies against neutrophils (c-ANCA) were negative. CT scan of the lung revealed scattered bullae and mild interstitial pulmonary fibrosis in the inferior lobe of the right lung. Color doppler ultrasound showed mitral regurgitation and reduced left ventricular diastolic function. Further laboratory examination revealed that the treponema pallidum antibody (19.5 S/CO), toluidine red unheated serum test (TRUST) (1:32), and treponema pallidum particle agglutination assay (TPPA) were positive, favoring a diagnosis of active syphilis, while other infection-related indicators i.e., human immunodeficiency virus (HIV) antibodies, T-spot, EB virus antibodies, and antibodies against cytomegalovirus (CMV) were negative. The pathologic results of perineal skin biopsy (Figure 9) were consistent to the feature of verruca plana by showing squamous hyperplasia with papillary hyperplasia, hyperkeratosis of the epidermis, and thickening of granular and spinous layer. The diagnoses of SLE, ASPPC, and SS were established according to the detailed examination mentioned above.