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Keratin
Published in Masahiko Mori, Histochemistry of the Salivary Glands, 2019
Acinic cell carcinomas or tumors are rare salivary gland tumors. Histochemically, they resemble normal serous cells. Clinico-pathologic studies suggest that intercalated duct cells may be the progenitor cells of acinic cell carcinomas as well as other salivary gland tumors.112–116 Regezi and Batsakis64 and Batsakis65 proposed that intercalated duct reserve cells are responsible for regeneration of the acinar-tubular complex, and acinic cell carcinomas may develop by an oncogenic stimulus. Warner et al.117 used immunohistochemical markers including amylase, lactoferrin, lysozyme, secretory component, and keratin to study acinar cell tumors. Most tumors were positive for keratin proteins.
Physiology of the Salivary Glands
Published in John C Watkinson, Raymond W Clarke, Terry M Jones, Vinidh Paleri, Nicholas White, Tim Woolford, Head & Neck Surgery Plastic Surgery, 2018
The lumen of the acinus communicates directly with the lumen of the duct. As seen in Figure 44.1, the ductal system, from proximal to distal, comprises the intercalated duct, striated duct and excretory duct.
Oral cavity
Published in Paul Ong, Rachel Skittrall, Gastrointestinal Nursing, 2017
Once inside the duct, the saliva is subject to modification by reabsorption and secretion. The duct of the salivary glands is divided into three anatomical areas: the intercalated duct, the striated duct and the excretory duct. The intercalated duct secretes bicarbonate into the lumen of the duct and absorbs chloride ions (Cl−).The striated duct absorbs sodium ions and secretes potassium ions (K+) into the saliva.The excretory duct makes no modifications.
The role of the Notch pathway in the pathogenesis of systemic sclerosis: clinical implications
Published in Expert Review of Clinical Immunology, 2021
Filipe Seguro Paula, José Delgado Alves
Apart from being implicated in fibroblast activation and differentiation into myofibroblasts, Notch signaling is central to a process of transdifferentiation called epithelial-to-mesenchymal transition (EMT). In different contexts, both during development and adult life, epithelial cells (including endothelium) may lose the expression of some epithelium-defining genes, such as several cytoskeleton proteins, E-cadherin and CD31, and acquire the expression of a different set of genes, typical of cells of mesenchymal origin, such as vimentin, alpha-smooth muscle actin and even collagen type I [22]. This results in the acquisition of a different cellular behavior, with the loss of direct contact with the basement membrane and the acquisition of motility through the extracellular matrix therefore behaving essentially as fibroblasts. It has been proposed, rather logically, that this would be the main mechanism for generating an increased numbers of fibroblasts in the site of injury and in fact it has been described in many organs and conditions. Notch signaling has been implicated in many of these, namely by regulating Snail transcription factors [43]. In tubulointerstitial fibrosis of the kidney for example, EMT occurs on intercalated duct epithelial cells, leading to an increased fibroblast number and increased deposition of ECM in the interstitium [44]. Not surprisingly, the signaling pathways that have been implicated in EMT are the same that are classically related to fibrosis, namely TGF-β, Notch, Wnt, Hh and PDGF.
Oral mucosa grafting in periorbital reconstruction
Published in Orbit, 2018
MSGs ranging from 1 to 5 mm in size, are predominantly present in the labial and buccal mucosa as well as the tongue base and posterior hard palate.80 In the lips, MSGs form a tightly packed continuous layer of single lobules between the quadratus labii and the labial mucosa.71 Labial MSGs are more numerous and surgically accessible than at other sites.72 MSGs develop from the upper respiratory ectoderm during the 12th gestational week as simple tubuloacinar units and are classified as exocrine glands. Compared to major salivary glands, the duct system of MSGs is less developed. The intercalated duct arising from the gland acinus tends to be longer, while the next segment of the duct system leading to the interlobular excretory duct, known as the striated duct is often absent. The short excretory duct transports saliva to the oral mucosa. MSGs secretions are mainly mucinous or seromucinous.80,81 MSGs have minimal or no sympathetic innervation and postganglionic parasympathetic innervation to the MSGs derived mainly from the lingual nerve, is primarily responsible for stimulating secretion.80
Possible radioprotection of submandibular glands in gamma-irradiated rats using kaempferol: a histopathological and immunohistochemical study
Published in International Journal of Radiation Biology, 2023
Salwa Farid Ahmed, Noura Mohammed Bakr, Nora Abdelgawad, Dina W. Bashir
The results of the examination of H&E stained tissue sections of the SMGs from the control albino rats (group K) were as follows: K1 and K2 were similar, and the sections showed a normal architecture (the same as untreated rats) of the secretory units and duct system where acini were mixed in serous and mucous cells and normal intact intercalated duct. The striated ducts had small columnar cells with central rounded nuclei and eosinophilic cytoplasm (Figure 2(A,B)). The blood vessels were occasionally seen around these ducts (Figure 2(B)).