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Published in Samar Razaq, Difficult Cases in Primary Care, 2021
This is the typical presentation of roseola infantum. Other names for this condition include sixth disease (a historical reference to the six rash-causing illnesses of childhood), exanthema subitum and 3-day fever. The rash appears as the child improves in his or her condition and most parents will tell you that they would not have come to see you had the rash not appeared. Parvovirus B19 causes slapped cheek syndrome, also known as fifth disease.
Obstetrics: Answers
Published in Euan Kevelighan, Jeremy Gasson, Makiya Ashraf, Get Through MRCOG Part 2: Short Answer Questions, 2020
Euan Kevelighan, Jeremy Gasson, Makiya Ashraf
The patient should be reassured that parvovirus B19 (‘slapped cheek’ syndrome) is not teratogenic and she can continue with her pregnancy (1). She should be advised to avoid contact with other pregnant women until she is proven to be immune or is non-infective (1). However, parvovirus B19 (PB19) is associated with non-immune hydrops (NIH), and some of these pregnancies result in fetal loss [up to 15%] (1). The greatest risk to the mother is when the infection occurs between 9 and 16 weeks. This pregnancy is 25 weeks so her risk of NIH is lower (1). She should be offered a blood test for PB19-specific IgM and IgG, which indicates recent infection and past infection, respectively. If only PB 19-specific IgG is present, she can be reassured that her baby is not at risk of NIH (1). [50% of the adult population are immune.] If PB 19-specific IgM is present, then she requires increased fetal surveillance with ultrasound scans to check for signs of fetal hydrops (1).
Mixture Modeling
Published in Leonhard Held, Niel Hens, Philip O’Neill, Jacco Wallinga, Handbook of Infectious Disease Data Analysis, 2019
Parvovirus B19 is a human virus that causes a childhood rash called fifth disease or slapped cheek syndrome. The virus is spread primarily by infected respiratory droplets. Symptoms usually begin around six days after exposure and last around a week. Infected individuals with normal immune systems are infective before they become symptomatic, but probably not afterwards [20]. Individuals with B19 IgG antibodies generally are considered immune to recurrent infection, although re-infection is possible in a minority of cases [21]. There is currently no vaccine available against this virus [22].
Emerging Viral Infections Causing Anterior Uveitis
Published in Ocular Immunology and Inflammation, 2019
Moncef Khairallah, Padmamalini Mahendradas, Andre Curi, Sana Khochtali, Emmett T. Cunningham
Acute Parvovirus B19 infection includes erythema infectiosum (slapped cheek syndrome or fifth disease), arthritis involving a few joints and most commonly the knee, and fever. It is usually a mild disease, but aplastic anemia is a possible complication. If acquired during pregnancy, the infection may also result in miscarriage.