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Therapeutic effectiveness
Published in Dinesh Kumar Jain, Homeopathy, 2022
Pityriasis rosea is an acute self-limiting disorder with a very characteristic skin rash mainly involving children and young adults. The treatment is essentially symptomatic. Most importantly, a patient should be reassured regarding the self-limiting nature of the rash (Criton, 2008, pp. 375–377).
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Published in Samar Razaq, Difficult Cases in Primary Care, 2021
Pityriasis rosea is a benign, self-limiting rash of unknown aetiology. Not infrequently, it is seen with viral infections, leading many to postulate that the rash is of viral origin. It is commonly seen in children and young adults. Typically, the rash is preceded by a single scaly lesion that may be round or oval in shape. This is known as a ‘herald patch’ and can easily be confused as a patch of eczema or tinea corporis. A few days later the widespread macular eruption appears, prompting a second (usually more worried) visit to the doctor. The child is usually well and the rash is rarely itchy. Patients should be advised that the rash may be present for 3 months and treatment is neither necessary nor effective. Various treatment modalities including antihistamines, topical steroids and oral antibiotics have been tried but have failed to provide good evidence to support their routine use. Antihistamines, however, may be used if the child complains of itching associated with the rash. Important differential diagnoses include secondary syphilis, guttate psoriasis and cutaneous T-cell lymphoma. Pityriasis versicolor is a rash caused by Malassezia, a yeast-like germ.
Adverse drug reactions on the skin
Published in Robert A. Norman, Geriatric Dermatology, 2020
While the etiology of idiopathic pityriasis rosea is unknown, we do know that various medications have been reported to give rise to this benign disorder. These are: barbiturates, beta-blockers, bismuth, captopril, clonidine, gold, griseofulvin, isotretinoin, labetalol, meprobamate, metronidazole, penicillin and tripelennamine.
Evaluation of thiol/disulfide homeostasis in patients with pityriasis rosea
Published in Cutaneous and Ocular Toxicology, 2019
Pityriasis rosea (PR) is a self-limiting, papulosquamous disease with an acute onset. It is seen in 2% of patients that present to dermatology outpatient clinics. Approximately 75% of PR patients are between 10 and 35 years of age. The disease usually manifests itself with a single round or oval, peripheral, coloured, squamous, erythematous patch or plaque of 2–10 cm in diameter, known as a herald patch. A few days or weeks later, smaller, more spread, usually bilateral and symmetrical patches appear with their long axes lying parallel to the Langer’s lines, forming a shape similar to that of a Christmas tree. Most lesions are asymptomatic, sometimes accompanied by itching. Although the duration of the disease varies, it usually lasts six to eight weeks. Constitutional symptoms may be present before or during the rash. The etiology of PR remains unclear. In addition to bacterial, fungal and viral agents that have been implicated, recent studies have also referred to Herpes virus types 6 and 7, as well as autoimmunity, psychological stress, and atopy as possible causes of the disease1–3. One study also showed the role of oxidative stress in the etiology of PR, which is an inflammatory skin disease4.
Double-blind randomized placebo-controlled trial to evaluate the efficacy and safety of short-course low-dose oral prednisolone in pityriasis rosea
Published in Journal of Dermatological Treatment, 2018
Sidharth Sonthalia, Akshy Kumar, Vijay Zawar, Adity Priya, Pravesh Yadav, Sakshi Srivastava, Atula Gupta
Pityriasis rosea (PR) is an acute, self-limiting papulo-squamous skin disorder characterized by a distinctive skin rash that has a generally predictable course. The lesions are typically round to oval, erythematous, and have a typical scale with the inner edge free. In three-fourths of the cases, a single, isolated oval scaly pink maculae or patch (the ‘herald’ or ‘mother patch’) appears on the body, particularly on the trunk, upper arms, neck or thighs, although it may be missed by the patient or abate till the patient seeks dermatological consultation. The rash is typically truncal and involvement of extremities is less common, except for in the ‘inverse’ variant. The rash of PR typically lasts ∼5 weeks and resolves by 8 weeks in >80% of patients; although it may last for upto 5 months in adults (1,2). However, the course of PR has been well-documented to sometimes assume persistence as well as relapse or recurrence (3–5). Apart from skin involvement, oral mucosa may also be involved in PR (6,7). Painless oropharyngeal lesions have been reported in 28% patients with PR recently (7). Compared to adults, children show a faster appearance of rash after the herald patch and an overall shorter course of the duration of the eruption (2,8,9). Some epidemiologic features (seasonal variation and clustering in house-holds) suggest that PR may indeed be an infectious disease. Reactivation of latent human herpes viruses (HHV)-6 and 7 infections has been suggested as the most probable etiologic agent (2,10–14).
Pityriasis rosea-like eruption induced by isotretinoin
Published in Cutaneous and Ocular Toxicology, 2018
Gülhan Gürel, Sevinç Şahin, Emine Çölgeçen
Pityriasis rosea (PR) is a common, self-limited and inflammatory skin disease1. The incidence of PR is 0.5–2% and it is more common in the 15–30 age group2. The etiology is not clearly known. Viral agents, autoimmunity, psychogenic factors and drugs have all been suggested as risk factors for PR3. Regarding etiology of PR, many studies established a causal role for systemic active HHV-6 (Human herpesvirus-6) and HHV-7 (Human herpesvirus-7) infection in the pathogenesis of PR, based on the detection of HHV-6 and HHV-7 DNA in plasma, HHV-6 and HHV-7 mRNA expression and specific antigens in skin lesions of PR patients4–6. In addition, herpes virus virions in various stages of morphogenesis were detected by electron microscopy in skin lesions and in the supernatant of co-cultured peripheral blood mononuclear cells (PBMCs) from PR patients7,8.