China
Africa
Explore chapters and articles related to this topic
The skin
Published in C. Simon Herrington, Muir's Textbook of Pathology, 2020
Pilomatrixoma is a common benign hair follicular tumour that attempts, unsuccessfully, to recapitulate the hair follicle matrix. These tumours tend to arise in childhood or early adulthood although any age can be affected. They have a predilection for the head and neck region and present as a slow-growing firm and sometimes cystic skin coloured nodule. Most pilomatrixomas are associated with activating somatic mutations in the CTNNB1 gene, which encodes β-catenin leading to increased cell proliferation and differentiation through the WNT signalling pathway. Although most pilomatrixomas are sporadic, rare cases of multiple pilomatrixomas may be associated with Gardner syndrome.
Skin and soft tissue
Published in Tor Wo Chiu, Stone’s Plastic Surgery Facts, 2018
Pilomatrixoma is a benign appendigeal tumour that most probably arises from hair matrix cells. Part of it is composed of dead calcified cells (this calcification may be demonstrated by ultrasound or X-ray) and presents as a dermal/subcutaneous tumour with stony hard consistency and often with an angulated shape – the ‘tent sign’– due to stretching of overlying skin. It is most common in the head, neck and upper extremity.
Benign and Malignant Conditions of the Skin
Published in John C Watkinson, Raymond W Clarke, Terry M Jones, Vinidh Paleri, Nicholas White, Tim Woolford, Head & Neck Surgery Plastic Surgery, 2018
Murtaza Khan, Agustin Martin-Clavijo
A pilomatricoma is a benign tumour that arises from hair matrix cells. It commonly affects children in the form of a solitary, angulated, hard nodule on the cheek, eyelid, scalp or neck. The lesions tend to grow slowly and are usually asymptomatic. Transformation to pilomatrix carcinoma is possible but extremely rare. Multiple lesions may be seen in patients with myotonic dystrophy. These lesions should be excised, as they never regress spontaneously. Recurrence can occur if they are not removed completely.
Surgical experiences in pediatric pilomatricoma: punch incision and elliptical excision
Published in Journal of Dermatological Treatment, 2023
Hoon Choi, Dong Hyun Shim, Chan Ho Na, Bong Seok Shin, Min Sung Kim
Pilomatricoma is a benign tumor originating from the matrix cells of a hair follicle and is a common adnexal skin tumor (1). Surgical excision is the treatment of choice; however, there are no standard guidelines regarding the techniques and appropriate margins to be achieved (1). It often occurs in exposed areas, such as the face and neck (1,2), which are cosmetically sensitive areas, and is more common in children; therefore, there is a need to minimize the surgical site and operating time. A punch is an instrument for skin biopsy that dermatologists can access easily and can be used to remove various skin tumors (3). Therefore, this study aimed to evaluate pediatric patients who underwent elliptical excision or punch incision for pilomatricoma.
Neoplasia in Turner syndrome: a retrospective cohort study in a tertiary referral centre in Belgium
Published in Acta Clinica Belgica, 2022
Cas Dejonckheere, Carolien Moyson, Francis de Zegher, Leen Antonio, Griet Van Buggenhout, Brigitte Decallonne
As shown in Table 3, various other benign neoplasms were discovered, with those arising from the skin being the most frequent. Two (1.9%) patients had a history of pilomatricoma, a benign skin neoplasm considered to originate from the hair cell matrix.