Nevus depigmentosus – Knowledge and References

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Childhood versus post-childhood vitiligo

Published in Electra Nicolaidou, Clio Dessinioti, Andreas D. Katsambas, Hypopigmentation, 2019

Electra Nicolaidou, Styliani Mastraftsi

The differential diagnosis of childhood SV mainly includes the nevus depigmentosus/hypochromic nevus and the nevus anemicus. Nevus depigmentosus is usually a congenital lesion that is stable in shape, which grows in proportion to the child's growth. Nevus anemicus is a congenital solitary, hypopigmented lesion, which is caused by a localized hypersensitivity to catecholamines with resultant vasoconstriction. The lesional skin in nevus anemicus is characterized by a normal number of melanocytes and normal amount of melanin.

Outcomes of autologous non-cultured melanocyte keratinocyte transplantation in vitiligo and nevus depigmentosus

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Journal Information

Published in Journal of Dermatological Treatment, 2022

Thanyanan Sritanyarat, Chanisada Wongpraparut, Natchaya Jansuwan, Punyanut Yothachai, Nuttaporn Nuntawisuttiwong, Narumol Silpa-archa

MKTP was also shown to be efficacious for the treatment of other leukodermas, such as nevus depigmentosus and piebaldism. For nevus depigmentosus, Mulekar, et al. (9) demonstrated good repigmentation ranging from 80–100% in 3 cases, while 2 other cases had a poor response. However, color mismatch was observed in 2 of the 3 cases that responded to the treatment. van Geel N, et al. (25) reported a single case that had 78% improvement, while Olsson, et al. (26) reported a poor response to treatment in one case. Our study found a good response in three cases of nevus depigmentosus at both the short- and long-term follow-ups.