China
Africa
Explore chapters and articles related to this topic
Nonmelanocytic Lesions
Published in Ashfaq A Marghoob, Ralph Braun, Natalia Jaimes, Atlas of Dermoscopy, 2023
Nicole Nagrani, Natalie M. Williams, Natalia Jaimes
Lymphangioma circumscriptum (LC) is a benign hamartomatous malformation characterized by slow-flow vascular lesions comprised of dilated lymphatic channels or cysts lined by lymphatic endothelial cells.11 LC may be present at birth or develop during the first few years of life. Clinically, they present as clusters of small translucent vesicle-like lesions filled with lymphatic fluid, reminiscent of frogspawn; lesions may also reveal sero-hematic or hemorrhagic papules due to the inclusion of blood.
How to manage lymphatic leakage involved in lymphangioma?
Published in Byung-Boong Lee, Peter Gloviczki, Francine Blei, Jovan N. Markovic, Vascular Malformations, 2019
Xi Yang, Xiaoxi Lin, Ningfei Liu
Lymphangioma circumscriptum has two components: the clinically obvious dermal vesicular component and a deeper subcutaneous cisternal element. The pathology of these two components shows the large dilated lymphatics on the skin surface and a deeper contractile lymphatic cistern, respectively. The malformed lymphatic cistern lies just above the deep fascia and is not in continuity with the normal lymphatic system around the tissues. The malformed lymphatic cistern produces continuous or intermittent pressure on the contained fluid, which results in saccular dilatation of the subepidermal lymphatics and the clinically visible vesicles3 (Figure 69.1).
Future and Novel Unexplored Indications of Retinoids
Published in Ayse Serap Karadag, Berna Aksoy, Lawrence Charles Parish, Retinoids in Dermatology, 2019
In a patient receiving isotretinoin, a small lymphangioma circumscriptum (LC) resolved with no relapse for months (79). Considering that the treatment for LC is largely surgical or requires sclerotherapy, retinois may provide an alternative oral treatment option.
Isotretinoin does not alter VEGF-A and VEGF-C levels: do retinoids behave differently in dose-dependent and/or in vivo/in vitro conditions?
Published in Cutaneous and Ocular Toxicology, 2020
Erhan Ayhan, Eşref Araç, Özgür Aslan
Vascular endothelial growth factor (VEGF) family consists of VEGF-A (known as VEGF), VEGF-B, VEGF-C, VEGF-D and placental growth factor (PlGF). VEGF-A is an important regulator involved in the developmental vasculogenesis, angiogenesis and differentiation of progenitor endothelial cells. VEGF-B and PlGF induce angiogenesis in normal tissues, but their activity is much weaker than that of VEGF-A1,2. VEGF-C and VEGF-D are produced from their precursors and regulate lymphangiogenesis3,4. There are publications reporting that retinoids including isotretinoin (13-cis-retinoic acid) are successful in lymphangioma circumscriptum, angiolymphoid hyperplasia with eosinophilia, diffuse dermal angiomatosis, and Kaposi’s sarcoma5–12. In some publications, the effect of success is claimed to be the inhibitory effect on VEGF5,6. However, in the literature, it is seen that various forms of retinoids have different results on VEGF-A and VEGF-C levels when tested at different dosages, in different diseases and under different conditions such as in vivo or in vitro.13–18 However, there is no study on using only isotretinoin and its effect on VEGF-A and VEGF C in humans. Therefore, we aimed to investigate whether isotretinoin commonly used in dermatology has an effect on VEGF-A and VEGF-C.
Lymphangioma circumscriptum treated with combination of Bleomycin sclerotherapy and Radiofrequency ablation
Published in Journal of Cosmetic and Laser Therapy, 2018
Ananta Khurana, Aastha Gupta, Arvind Ahuja, Kabir Sardana, Purnima Malhotra
Lymphangioma circumscriptum (LC) is a microcystic lymphatic malformation that usually presents at birth or during early childhood, as translucent vesicles of varying sizes over the proximal parts of limbs, flanks, tongue, or the perineum (1). Although frequently asymptomatic, patients usually seek therapy due to complications such as lymphorrhea, infection, or for cosmetic reasons. The treatment is difficult with high recurrence rates. We herein describe a case of LC managed successfully using intralesional bleomycin along with radiofrequency ablation (RFA).
EDITORIAL
Published in Journal of Cosmetic and Laser Therapy, 2018
This edition of the Journal is full of studies related to the use of energy based devices. The 1st series looks at perplexing problems such as enhancing the effect treating melasma using topical tranexamic acid with a Q-switched Nd: YAG laser and combining bleomycin sclerotherapy with radiofrequency (RF) ablation of lymphangioma circumscriptum.