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Dermatologic diseases and pregnancy
Published in Hung N. Winn, Frank A. Chervenak, Roberto Romero, Clinical Maternal-Fetal Medicine Online, 2021
Holly Edmonds, Dana Ward, Ann G. Martin, Susana Leal-Khouri
The cause of hirsutism is unknown, but it is thought to be due to increased ovarian androgen secretion or increased adrenocorticotropic hormone secretion (24,25). Patients with marked persistent hirsutism should have an appropriate evaluation to exclude virilizing tumors. Therapy consists of reassuring the patient, although when hirsutism persists more than 6 months postpartum, cosmetic treatment (hair removal lasers or electrolysis) may be considered.
Paper III
Published in Justin C Konje, Complete Revision Guide for MRCOG Part 3, 2020
Applied clinical knowledgeDemonstrates being up to date with current literature on hirsutism as evidenced from Discussion of diagnosis of PCOS and differentialsTreatment options – focus on hirsutism – mechanical (bleaching, shaving, depilatory, waxing, laser and drugs – hormones – combined hormonal contraception and anti-androgens)Discussion on weight control and lifestyle modificationImplications for fertility and periodsFamiliarity with current guidelines, e.g. ESHRE and International Consensus Guidelines on diagnosis and management of PCOS
Carbamazepine
Published in Stanley R. Resor, Henn Kutt, The Medical Treatment of Epilepsy, 2020
Laboratory evidence of reduced thyroid hormone concentration (67) and biochemical features of osteomalacia (53) are noted in as many as 20 to 30% of the patients who take CBZ. Clinical hypothyroidism (68) or overt osteomalacia (49) are, however, rare. As an enzyme-inducing agent CBZ can cause oral contraceptive failure (69). Hirsutism may rarely occur, possibly related to changes in circulating androgens (70).
An evaluation of the available pharmacotherapy for the treatment of hirsutism
Published in Expert Opinion on Pharmacotherapy, 2023
Leila Asfour, Ahmed Kazmi, Rodney Sinclair
Hirsutism is defined as excessive growth of terminal hair in androgen-sensitive sites in a woman. It is crucial to take into consideration a patient’s ethnic background and potential cultural influences on their self-perception of hirsutism. There is a discordance between clinician assessment and patient perception of degree of hirsutism. Ensure you have reviewed for any underlying causes of hyperandrogenism. The commonest cause for hirsutism is PCOS and idiopathic hirsutism. It can be associated with severe psychosocial morbidity impacting on patients’ quality of life and relationships. A multimodal approach for optimal treatment is required combining medical with physical therapies. Pharmacotherapy in hirsutism will continue to evolve as we gain increasing experience in the use of anti-androgens. However, currently there is low-level evidence informing our use of the available treatments, predominantly due to poor study design.
Regional variability of modified Ferriman-Gallwey scorring in premenopausal healthy women in Southern Turkey
Published in Gynecological Endocrinology, 2022
Gurgun Tugce Vural Solak, Gamze Akkus, Yavuzalp Solak, Sevgul Kose, Murat Sert
Generally, it has been accepted hirsutism is a sign of endocrine abnormality caused to androgen excess or exaggerated androgen responsiveness. Beyond the common etiological causes of hirsutism (PCOS, idiopathic hyperandrogenism, congenital adrenal hyperplasia, and ovarian tumors), inexplicit terminology called, ‘idiopathic hirsutism’, it is difficult to establish the prevalence of this clinical disorder; also the presence of idiopathic hirsutism is arguable [18–20] The pathogenesis of idiopathic hirsutism is not clear, but it is associated with normal ovulatory function and androgen levels [21]. Increased skin 5α-reductase activity and possible alterations in the androgen receptor (AR) function are considered as the underlying causes of IH [22, 23]. Furthermore, we know that the hair-growth patterns show racial-ethnic variations, so we want to highlight that the quantification of hirsutism should be established for the population in which it is applied.
Comparison of patient satisfaction with diode laser treatment of female hirsutism: low fluence or high fluence?
Published in Journal of Cosmetic and Laser Therapy, 2021
Mohammad Ebrahimzadeh Ardakani, Mehran Azad, Narges Ghanei, Farshid Etaee, Tarek Naguib, Steven Daveluy
Hirsutism, defined as excessive hair growth in androgen-sensitive areas, affects 5%‐10% of reproductive‐aged women worldwide. Hirsutism has undesirable psychological effects and impairs the quality of life, especially among young women (1). Hirsutism and be familial/idiopathic or related to several underlying conditions: polycystic ovarian syndrome, congenital adrenal hyperplasia, thyroid gland dysfunction, Cushing syndrome, hyperprolactinemia, and consumption of medications such as cyclosporine, danazol, and diazoxide (2,3). There are several treatments for hirsutism including epilation, antiandrogens, electrolysis, and laser hair removal (4). Laser hair removal is an FDA-approved method for permanent hair reduction available since 1997 (5). In hair removal laser therapy, exposure to laser light pulses destroys hair follicles via selective photothermolysis (6). Laser therapy acts on actively growing hair follicles and typically needs three to six or more sessions to effectively eliminate excessive hair (7). There are various techniques for laser therapy. The low-fluence technique uses lower energy levels, resulting in less pain (8). Quickness and efficiency make laser therapy a popular method for hair removal therapy (9). Side effects following laser therapy include redness, skin burn, and follicular edema. Also, pain should be expected during therapy (10). The side effects of laser therapy, especially pain, impact patient satisfaction (11).