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Parvovirus
Published in Vincenzo Berghella, Maternal-Fetal Evidence Based Guidelines, 2022
In adults, at least half of the infections are asymptomatic [2]. About 30% may have flu-like symptoms, arthralgias, and adenopathy. Parvovirus B19 causes a common exanthematous disease in children 5–14 years old, called fifth disease or erythema infectiosum. Children have symptoms such as low-grade fever and a “slapped-cheeks” rash, and are usually diagnosed just based on these symptoms.
Hemolytic Anemia Associated with Red Cell Membrane Defects
Published in Harold R. Schumacher, William A. Rock, Sanford A. Stass, Handbook of Hematologic Pathology, 2019
Erythroid hyperplasia increases HS patients’ requirements for folate. When pregnancy, malabsorption, or malnutrition produce folate deficiency, a “megaloblastic crisis” can ensue due to impaired compensation. “Aplastic crisis” results from infection by B19 parvovirus. This common viral infection affects bone marrow erythroblasts leading to transient erythroid aplasia and profound anemia in patients with chronic hemolysis. In normal individuals, B19 parvovirus produces a mild viral syndrome that may include a typical exanthem in children, termed “fifth disease.”
Viral infections
Published in Biju Vasudevan, Rajesh Verma, Dermatological Emergencies, 2019
The most common form of infection is erythema infectiosum, or “fifth disease.” In general, regardless of the clinical presentation, the virus is self-limited with the exception of a few circumstances [2]. It is transmitted through respiratory secretions, blood products, or vertically during pregnancy. Although parvovirus B19 is more common in children, infection does occur in adults.
Fetal hydrops – a review and a clinical approach to identifying the cause
Published in Expert Opinion on Orphan Drugs, 2020
Esther Dempsey, Tessa Homfray, John M Simpson, Steve Jeffery, Sahar Mansour, Pia Ostergaard
Erythema infectiosum (also known as fifth disease) is a common disease of childhood and mainly causes a mild flu-like illness with or without pruritus and erythematous malar rash (‘slapped cheek’). The condition is most frequently caused by contact with respiratory droplets infected with Parvovirus B19 (PB19), a single-stranded DNA virus. By reproductive age just over half of women are immune to PB19 [20,21]. However, an additional 1.5% of pregnant women seroconvert each year during endemic periods [22].
Emerging Viral Infections Causing Anterior Uveitis
Published in Ocular Immunology and Inflammation, 2019
Moncef Khairallah, Padmamalini Mahendradas, Andre Curi, Sana Khochtali, Emmett T. Cunningham
Acute Parvovirus B19 infection includes erythema infectiosum (slapped cheek syndrome or fifth disease), arthritis involving a few joints and most commonly the knee, and fever. It is usually a mild disease, but aplastic anemia is a possible complication. If acquired during pregnancy, the infection may also result in miscarriage.