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Clinical, genetic and experimental studies of the Brooke–Spiegler (CYLD) skin tumor syndrome
Published in Journal of Plastic Surgery and Hand Surgery, 2019
Mattias K. Andersson, Lars Kölby, Jonas A. Nilsson, Göran Stenman
Three months after transplantation, increased tumor growth was detected in one of the three remaining mice (Figure 3(A)). The growth continued for a month after which it ceased. The other two xenografts showed no signs of increased tumor volume during the study period (Figure 3(A)). The mice were sacrificed 6 months after transplantation, after which the remaining tumor tissues were removed for histopathological and immunohistochemical analyses. The morphology of the xenografts was almost identical to the corresponding primary tumors (Figure 3(B)). The xenografted tumors were composed of multiple nodules of uniform, basaloid tumor cells. The nodules were arranged in a jigsaw pattern, typical of dermal cylindroma (Figure 3(B)), and were surrounded by a rim of hyalinized basement membrane material of variable thickness. There were no signs of atypia or of malignant transformation in any of the xenografts.