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Malignant diseases of the skin
Published in Rashmi Sarkar, Anupam Das, Sumit Sethi, Concise Dermatology, 2021
Anupam Das, Yasmeen Jabeen Bhat
This is the term used for squamous cell carcinoma in situ affecting the glans penis and vulva. It presents as a red, velvety patch that slowly progresses, eventually transforming into a squamous cell carcinoma if left untreated. Surgical excision of the affected area is the best form of treatment. Anogenital HPV-induced scc in situ is referred to as bowenoid papulosis.
Diseases
Published in William Bonnez, Guide to Genital HPV Diseases and Prevention, 2019
Before VIN and PIN were recognized as such, two clinically characteristic variants had been identified, both predominantly associated with HPV-16 infection. One is bowenoid papulosis and the other is Bowen’s disease. Bowenoid papulosis in its strictest definition is a clinical and histologic entity characterized by aggregated, multicentric papules, ranging in color from dark red to dark blue, while the cytoarchitecture is that of a condyloma with the histology of an intraepithelial neoplasia. It may transition to Bowen’s disease, a carcinoma in situ that appears as a flat, scaly plaque, red to brown in color, an irregular surface contour, but with sharp borders. Erythroplasia of Queyrat is Bowen’s disease confined to the glans penis. This nomenclature should be abandoned in favor of the broader VIN and PIN denomination (Fig. 3.9).
Malignant and premalignant conditions affecting the genital area
Published in Shiv Shanker Pareek, The Pictorial Atlas of Common Genito-Urinary Medicine, 2018
Squamous cell carcinoma is the most frequently occurring penile cancer. It may be present on the glans penis, prepuce or shaft of the penis and is slow growing initially, without affecting erectile function, ejaculation or urination. Consequently, many patients do not seek medical attention immediately. Several risk factors are associated with the premalignant condition, possibly predisposing the patient to squamous cell carcinoma: Bowen’s disease of the glans penis (also called Queyrat’s erythroplasia).bowenoid papulosis.human papillomavirus.balanitis xerotica obliterans (also called lichen sclerosus; previously lichen sclerosus et atrophicus).leukoplakia – a precancerous oral lesion.phimosis.
The management of penile intraepithelial neoplasia (PeIN): clinical and histological features and treatment of 345 patients and a review of the literature
Published in Journal of Dermatological Treatment, 2022
G. Kravvas, L. Ge, J. Ng, T. N. Shim, P. R. Doiron, R. Watchorn, J. Kentley, E. Panou, M. Dinneen, A. Freeman, C. Jameson, A. Haider, N. Francis, S. Minhas, H. Alnajjar, A. Muneer, C. B. Bunker
PeIN is synonymous with other histological terms that have previously been used including penile carcinoma in situ (PCIS) and squamous intraepithelial lesion (SIL). Clinically, three principal morphological entities are recognized, being bowenoid papulosis (BP), erythroplasia of Queyrat, (EQ) and Bowen’s disease of the penis (BDP) (1,7). Histologically, PeIN is characterized by dysplastic changes with an intact basement membrane and is now subdivided into differentiated (non-HPV-related and lichen sclerosus (LSc)-related) and undifferentiated (HPV-related) that in turn are associated with specific PSSC subtypes (1,6,8–10). Most risk factors for PeIN (and PSCC) are known and primary prevention should be achievable (1,9,11,12). Treatment can be medical and surgical.
Risk factors for cutaneous warts and the influence factors of curative effect of 5-flurouracil therapy in southern China
Published in Journal of Dermatological Treatment, 2021
Zhi P. Xiao, Que P. Liu, Hong F. Xie, Ji Li, Ming L. Chen, Dan Jian
In total, 408 cutaneous warts patients and 408 controls of Chinese Han population in southern China were enrolled into the study. In our research, the diagnosis of warts was confirmed by physical examination, clinical behavior of the lesions, and skin biopsy (if it is necessary) by two senior dermatologists for every patient. This study did not cover flat wart, anogenital warts, bowenoid papulosis, focal epithelial hyperplasia, or seborrheic keratoses. Controls were recruited from the physical examination center without skin disease. Two hundred and forty-four patients, aged ≥10 years old with less than 15 new cutaneous warts were recruited into the intralesional 5-FU treatment group. New cutaneous warts were defined as lesions on the skin that were not previously treated. A standardized questionnaire was administered in face-to-face interview to both patients and control subjects by trained dermatologists. Informed consent was obtained from all individual participants included in the study. All procedures performed in studies involving human participants were approved by the institutional ethics committee.
Rapid detection and subtyping of human papillomaviruses in condyloma acuminatum using loop-mediated isothermal amplification with hydroxynaphthol blue dye
Published in British Journal of Biomedical Science, 2018
Q Zhong, K Li, D Chen, H Wang, Q Lin, W Liu
LAMP has been reported to detect various types of infectious agents, including varicella-zoster virus, SARS coronavirus, herpes simplex virus, measles virus, mumps virus and influenza virus [20–25]. HPV is detectable in CA and in bowenoid papulosis, and represents a potentially problematic sexually transmitted disease [26]. It is therefore important to identify the causative genital HPV type, from both epidemiological and public health perspectives. The results of the current study suggest that LAMP may be a useful and accurate technique for the detection of HPV subtypes in clinical CA samples.