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Introduction to dermatological treatment
Published in Richard Ashton, Barbara Leppard, Differential Diagnosis in Dermatology, 2021
Richard Ashton, Barbara Leppard
Chlorhexidine and benzalkonium chloride are combined with moisturisers and soap substitutes (DermolUK, EczmolUK). Aqueous cream contains phenoxyethanol 1%. These can all be irritant especially in patients with atopic eczema.
The administration of medicines to children
Published in Evelyne Jacqz-Aigrain, Imti Choonara, Paediatric Clinical Pharmacology, 2021
Evelyne Jacqz-Aigrain, Imti Choonara
Allowing children with eczema to pick their favourite emollient from a tray of all those available has been shown to enhance compliance by empowering the child to use the product of their choice, thus avoiding those which they find unpleasant and are not willing to use [25]. An audit of emollient use in children with eczema revealed a large proportion of children not using the aqueous cream which had been prescribed for them, due to their suffering immediate cutaneous reactions to it [25].
Radiotherapy: The Prevention of Secondary Effects, Radiodermatitis, and Long-Term Toxicity
Published in Paloma Tejero, Hernán Pinto, Aesthetic Treatments for the Oncology Patient, 2020
Chang et al. [14] investigated the effects of an oil-based natural emulsion containing allantoin versus an aqueous cream, to prevent and control radiation-induced skin reactions. In general, aqueous cream seems to be a more preferred option.
Vehicles for atopic dermatitis therapies: more than just a placebo
Published in Journal of Dermatological Treatment, 2022
Simon G. Danby, Zoe D. Draelos, Linda F. Stein Gold, Amy Cha, Bonnie Vlahos, Laraine Aikman, Paul Sanders, Dan Wu-Linhares, Michael J. Cork
The benefits of using emollients are highly dependent on the frequency of application (51), in agreement with the transient effects of occlusive ingredients. Although there is very limited evidence comparing emollients with other emollients, it is clear that not all emollients are equal. Some emollients, like Aqueous Cream BP, containing harsh surfactants, damage the skin barrier and consequently increase the risk of cutaneous adverse reactions (76). Glycerol-based emollients in general exhibit significantly greater efficacy at treating skin dryness compared to emollients without glycerol, and concordantly demonstrate greater overall efficacy in treating AD (48). Caution is required in generalizing the benefits of emollients based on a single perceived active ingredient, however, as the interaction between active moisturizing agents and other excipients is known to substantially affect overall efficacy, much like vehicle design appreciably affects drug delivery and response (77,78). Unfortunately, few studies directly compare the efficacy of emollients at reducing the severity of AD or improving the control of the condition, especially considering the wide array of emollient formulations available. In a recent example, Akerstrom et al. directly compared a urea-containing emollient to a bland emollient without humectants in a randomized, controlled flare prevention trial (79). A greater than two-fold difference in the propensity to new flares of AD was found between the treatment groups. Together these findings on emollients support a wider role for emollients as important adjuvants to topical active therapies such as TCSs, rather than stand-alone therapies.
New synthetic pharmacotherapeutic approaches to the treatment of moderate-to-severe plaque psoriasis in adults
Published in Expert Opinion on Pharmacotherapy, 2023
Rithi J. Chandy, Sarah G. Bridgeman, Brandon M. Godinich, Steven R. Feldman
A similar phase III trial was recently completed in Germany; while all data are not currently published, a pooled analysis has been performed using these two clinical trials to assess patient-reported treatment outcomes [30]. These included the Subject Global Assessment (SGA), Dermatology Life Quality Index (DLQI), and European Quality of Life-5 Dimensions (EQ-5D), and the mean PTCS. In every assessment, the CAL/BDP cream had greater efficacy than the topical suspension/gel (p < 0.0001 in all assessments). Based on these findings, the authors conclude that patients may be more likely to adhere to therapy with the aqueous cream-based solution.
An overview of drug discovery efforts for eczema: why is this itch so difficult to scratch?
Published in Expert Opinion on Drug Discovery, 2020
Kam Lun Hon, Steven Loo, Alexander K. C. Leung, Joyce T. S. Li, Vivian W. Y. Lee
Aqueous cream is one of the oldest moisturizers that has been used for AD. However, it contains sodium lauryl sulfate (SLS) and its use is now discouraged due to skin irritability and sensitization [58,59]. And while many AD products are available on the market, very few have been subjected to trials to document efficacy.